NIDA Research Monograph, Number 120 [Printed in 1992]
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Download Monograph120.pdf - Bioavailability of Drugs to the Brain and Blood-Brain Barrier (1.5 MB)
Table of Contents
Introduction-----1
Jerry Frankenheim
The Basic Neurobiology of Addiction-----4
Roger M. Brown
Some Relationships Between Addiction and Drug Delivery to the Brain-----13
William H. Oldendorf
Neuroactive Peptides and Amino Acids at the Blood Brain Barrier: Possible Implications for Drug Abuse-----26
Berislav V. Zlokovic, J. Gordon McComb Lynn Perlmutter, Martin H. Weiss, and Hugh Davson
MPTP Toxicity and the "Biochemical" Blood-Brain Barrier-----43
Sami I. Harik
An Overview of the Multiple Functions of the Blood-Brain Barrier-----54
A. Lorris Betz
Formation and Differentiation of Brain Capillaries.-----73
John Laterra, Johannes E.A. Wolff, Christopher Guerin, and Gary W. Goldstein
Nonpermeable and Permeable Vessels of the Brain-----87
Milton W. Brightman and Yoshiaki Kadota
The Blood-Brain Barrier Is Not a "Barrier" for Many Drugs-----108
Joseph D. Fenstermacher
Drug Delivery to the Brain: Barrier Modification and Drug Modification Methodologies-----121
Stanley I. Rapoport
Cultured Brain Microvessel Endothelial Cells as In Vitro Models of the Blood-Brain Barrier-----138
Yoshinobu Takakura, Kenneth L. Audus, and Ronald T. Borchardt
Opioid Peptide Drug Development: Transport of Opioid Chimeric Peptides Through the Blood-Brain Barrier-----153
William M. Pardridge
Redox Approaches to Drug Delivery to the Central Nervous System-----169
Marcus E. Brewster and Nicholas Bodor
Drug Delivery to the Brain Using an Anti-Transferrin Receptor Antibody-----202
Phillip M. Friden, Lee Walus, Marjorie Taylor, Gary F. Musso, Susan A. Abelleira, Bernard Malfroy, Fariba Tehrani, Joseph B. Eckman III. Anne R. Morrow, and Ruth M. Starzyk
Permeation of the Blood-Brain Barrier for Drug Delivery to the Brain-----218
Heidi C. Horner, Kari Barbu, Frederique Bard, Deborah Hall, Mary Janatpour, Katy Manning, Janine Morales, Seth Porter, Paulette E. Seller, Laura Tanner, and Lee R. Rubin
Pathways Into, Through, and Around the Fluid-Brain Barriers-----230
Richard D. Broadwell
List of NIDA Research Monographs-----259
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