NIDA Research Monograph, Number 69 [Printed in 1986]
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Download Monograph69.pdf - Opioid Peptides: Medicinal Chemistry (3.7 MB)
Table of Contents
Foreword-----v
Marvin Snyder
Introduction-----1
Rao S. Rapaka
Frontiers of Research in the Medicinal Chemistry and Molecular Pharmacology of Opioid Peptides-----3
Rao S. Rapaka
Synthesis of Opioid Peptide Analogs-----21
John M. Stewart
Structure-Activity Relationships of Opioid Peptides-----42
J. S. Morley and A. S. Dutta
Design Principles: Enkephalins With Predictable Mu/Delta Receptor Specificity-----65
Yasuyuki Shimohigashi
Structure-Activity Relationship and Pharmacology of the Highly Selective µ-Opioid Agonist, Morphiceptin-----101
Kwen-Jen Chang
Dermorphin: Autonomic Pharmacology and Structure-Activity Relationships-----112
Giora Feuerstein
Design of Conformationally Constrained Cyclic Peptides With High Delta and Mu Opioid Receptor Specificities-----128
Victor J. Hruby
Dehydro and Cyclopropyl Amino Acids and Peptides-----148
Charles H. Stammer
Affinity Labels as Probes for Opioid Receptor Types and Subtypes-----157
Phillip S. Portoghese and A. E. Takemori
Peptide Conformation and Biological Activity: A General Review with Examples of Approaches Relevant to Opioid Peptide Function-----169
Dan W. Urry
Opioid Peptides: Analysis of Specificity and Multiple Binding Modes Through Computer-Aided Drug Design and Structure-Activity Studies-----204
Raoul D. Nelson; David I. Gottlieb; T. M. Balasubramanian; and Garland R. Marshall
Mechanistic Structure-Activity Studies of Peptide and Nonpeptide Flexible Opioids: An Interdisciplinary Approach-----231
Gilda H. Loew; Lawrence Toll; Edward Uyeno; Alice Cheng; Amrit Judd; John Lawson; Christopher Keys; Peter Amsterdam; and Wilma Polgar
Conformations of Opioid Peptides as Determined by Nuclear Magnetic Resonance and Related Spectroscopies-----266
M. Abu Khaled
Conformational Analysis of Opioid Peptides and the Use of Conformational Restriction in the Design of Selective Analogs-----291
Peter W. Schiller
Stereochemically Constrained Enkephalin Analogs Containing X-Aminoisobutyric Acid and 1-Amino-Cyclopentane-l-Carbolylic Acid-----312
Raghuvansh Kishore and Patinabhan Balaram
Enkephalin Conformation in Solution: A Perspective From Vibrational Spectroscopic Studies-----332
V. Renugopalakrishnan; T. W. Collette; L. A. Carreira; and R. S. Rapaka
Conformational Features of the Opioid Peptides in the Solid State: A Review of X-Ray Crystallographic Research-----351
Arthur Camerman and Norman Camerman
The Search for Nonaddicting Strong Analgesics: Hopes and Frustrations-----364
Sydney Archer
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