NIDA Research Monograph, Number 79 [Printed in 1987]
If you have the Acrobat reader plug-in for Netscape or Internet Explorer click on the document link and you will be able
to view and/or print out the pages. If you have trouble viewing the document in your browser window, download the document (Windows users - right click on the link and Save as...) to your computer and get Adobe Acrobat Reader (free) in order to view it.
This monograph is not available by chapter. The Table of Contents (below) is shown to assist in locating information prior to downloading the monograph.
Download Monograph79.pdf - Structure-Activity Relationships of the Cannabinoids (2.1 MB)
Table of Contents
Preface-----v
Introduction-----1
Rao S. Rapaka and Alexandros Makriyannis
Structure-Activity Relationships in Cannabinoids: An Overview-----3
Raj K. Razdan
Stereochemical Requirements for Cannabimimetic Activity-----15
Raphael Mechoulam; Naphtali Lander; Morris Srebnik; Aviva Breuer; Mark Segal; Jeffery J. Feigenbaum; Tobjorn U. C. Jarbe; and Paul Consroe
Structure-Activity Relationships of Tricyclic and Nonclassical Bicyclic Cannabinoids-----31
Larry S. Melvin and M. Ross Johnson
Structure-Anticonvulsant Activity Relationships of Cannabidiol Analogs-----48
Arnold R. Martin; Paul Consroe; Vinayak V. Kane; Vibhakar Shah; Vishwakarma Singh; Naftali Lander; Raphael Mechoulam; and Morris Srebnik
Anticonvulsant and Neurotoxic Effects of Tetrahydrocannabinol Stereoisomers-----59
Paul Consroe and Raphael Mechoulam
Different Cannabinoids Exhibit Different Electrophysiological Properties-----67
Stuart A. Turkanis and Ralph Karler
Molecular Determinants for Cannabinoid Activity: Refinement of a Molecular Reactivity Template-----82
Patricia H. Reggio
Different Cannabinoids Exhibit Different Pharmacological and Toxicological Properties-----96
Ralph Karler and Stuart A. Turkanis
Pharmacological Evaluation of Agonistic and Antagonistic Activity of Cannabinoids-----108
Billy R. Martin; Thomas J. Martin David R. Compton; Patrick J. Little; and Patrick M. Beardsley
Interactions of Cannabinoids With Membranes. The Role of Cannabinoid Stereochemistry and Absolute Configuration and the Orientation of Delta-9-THC in the Membrane Bilayer-----123
Alexandros Makriyannis; Ali Banijamali; Cornelis Van Der Schyf; and Harold Jarrell
The High Affinity Cannabinoid Binding Site in Brain: Regulation by Guanine Nucleotides and Isolation of an Endogenous Inhibitor-----134
Jeffrey S. Nye and Solomon H. Snyder
Regulation of Adenylate Cyclase in a Cultured Neuronal Cell Line by Marijuana Constituents, Metabolites of Delta-9-tetrahydrocannabinol, and Synthetic Analogs Having Psychoactivity-----148
Allyn C. Howlett
Inhibitory and Stimulatory Effects of Cannabinoids on Eicosanoid Synthesis-----158
Sumner H. Burstein
Pharmacokinetics and Disposition of Cannabinoids-----173
C. Nora Chiang and Rao S. Rapaka
Drug Abuse in India: Progress in Research-----189
B. N. Dhawan
The Medicinal Chemistry of Cannabinoids: An Overview-----204
Alexandros Makriyannis and Rao S. Rapaka
List of NIDA Research Monographs-----211
|