Prepared by:
New England Medical Center Evidence-based Practice Center
Joseph Lau, M.D.
EPC/Project Director
Ethan Balk, M.D., M.P.H.
Assistant Project Director
Michael Rothberg, M.D.
John P.A. Ioannidis, M.D.
Deirdre DeVine, M.Litt.
Priscilla Chew, M.P.H.
Bruce Kupelnick, B.A.
Kimberly Miller, B.A.
Investigators
File Name Description Software Version File Size __________________________________________________________________________________________________________ 01front.doc Microsoft Word® Document MS Word® 2002 32KB 3 pages Contents: Title Page, Preface 02abstr.doc Microsoft Word® Document MS Word® 2002 29KB 2 pages Contents: Structured Abstract 03conts.doc Microsoft Word® Document MS Word® 2002 131KB 5 pages Contents: Table of Contents 04summ.doc Microsoft Word® Document MS Word® 2002 84KB 6 pages Contents: Summary: Overview; Reporting the Evidence; Methods; Findings; Future Research 05chap1.doc Microsoft Word® Document MS Word® 2002 100KB 7 pages Contents: Chapter 1. Introduction: Overview; Clinically Inapparent Adrenal Mass; Survival for Adrenal Cortical Carcinoma; Management of Adrenal Incidentaloma 06chap2.doc Microsoft Word® Document MS Word® 2002 61KB 8 pages Contents: Chapter 2. Methods: Key Questions Addressed in this Report; Definition of Adrenal Incidentaloma; Literature Search; Study Selection; Summarizing the Literature 07chap3.doc Microsoft Word® Document MS Word® 2002 1.5MB 56 pages Contents: Chapter 3. Results: Findings for Specific Questions: Question 1. What are the causes and prevalence of clinically inapparent adrenal masses?; Question 2. What is the diagnostic accuracy (sensitivity, specificity) of evaluation modalities (FNA/biopsy, CT, MRI, US, biochemical tests) used to differentiate adrenal masses (adrenal carcinoma, pheochromocytoma, adenoma, adrenal hyperplasia, etc.)?; Question 3. What are the surgical complication rates for various approaches used to excise adrenal masses; specifically laparoscopic, transabdominal, and retroperitoneal approaches?; Question 4. What are the patient outcomes after surgical excision of adrenocortical carcinoma (morbidity and mortality)?; Question 5. What evidence is there to support the use of periodic biochemical and imaging studies to follow untreated adrenal masses? 08chap4.doc Microsoft Word® Document MS Word® 2002 32KB 3 pages Contents: Chapter 4. Conclusions 09chap5.doc Microsoft Word® Document MS Word® 2002 29KB 2 pages Contents: Chapter 5. Future Research: The Need to Understand Issues Related to the Diagnosis of Incidentaloma; Diagnostic Tests to Evaluate Adrenal Mass; Assessment of Surgical Techniques for Adrenalectomy; Follow up of Untreated Adrenal Masses; The Need for an International Registry of Adrenal Incidentaloma 10refs.doc Microsoft Word® Document MS Word® 2002 64KB 10 pages Contents: References 11etbl1.doc Microsoft Word® Document MS Word® 2002 352KB 23 pages Contents: Evidence Table 1. Prevalence of pathologies of adrenal incidentaloma 12etbl2.doc Microsoft Word® Document MS Word® 2002 649KB 36 pages Contents: Evidence Table 2. Diagnostic performance of tests to evaluate adrenal masses 13etbl3.doc Microsoft Word® Document MS Word® 2002 142KB 15 pages Contents: Evidence Table 3. Risk of complications from fine needle aspiration biopsy of the adrenal gland 14etbl4.doc Microsoft Word® Document MS Word® 2002 45KB 1 page Contents: Evidence Table 4. Cohort/series of surgical complications of open transperitoneal adrenalectomy 15etbl5.doc Microsoft Word® Document MS Word® 2002 125KB 6 pages Contents: Evidence Table 5. Cohort/series of surgical complications of open retroperitoneal adrenalectomy 16etbl6.doc Microsoft Word® Document MS Word® 2002 92KB 7 pages Contents: Evidence Table 6. Surgical complications of comparative open adrenalectomy techniques 17etbl7.doc Microsoft Word® Document MS Word® 2002 336KB 24 pages Contents: Evidence Table 7. Surgical complications of transperitoneal laparoscopic adrenalectomy 18etbl8.doc Microsoft Word® Document MS Word® 2002 157KB 10 pages Table 13. Evidence Table 8. Surgical complications of retroperitoneal laparoscopic adrenalectomy 19etbl9.doc Microsoft Word® Document MS Word® 2002 373KB 33 pages Contents: Evidence Table 9. Surgical complications of open vs. endoscopic adrenalectomy techniques 20etbl10.doc Microsoft Word® Document MS Word® 2002 142KB 11 pages Contents: Evidence Table 10. Surgical complications of comparative endoscopic adrenalectomy techniques 21etbl11.doc Microsoft Word® Document MS Word® 2002 358KB 36 pages Contents: Evidence Table 11. Morbidity/mortality of adrenocortical carcinoma after surgical excision 22etbl12.doc Microsoft Word® Document MS Word® 2002 72KB 7 pages Contents: Evidence Table 12. Follow-up studies of incidentally discovered untreated adrenal masses by established protocol 23etbl13.doc Microsoft Word® Document MS Word® 2002 77KB 4 pages Contents: Evidence Table 13. Follow-up studies of incidentally discovered untreated adrenal masses without established protocol 24biblio.doc Microsoft Word® Document MS Word® 2002 20KB 1 page Contents: Bibliography 25appa.doc Microsoft Word® Document MS Word® 2002 29KB 3 pages Contents: Appendix A. Literature Search Strategies 26appb.doc Microsoft Word® Document MS Word® 2002 25KB 2 pages Contents: Appendix B. Acknowledgements 27appc.doc Microsoft Word® Document MS Word® 2002 49KB 7 pages Contents: Appendix C. Biases of Case Series and Potential Hazards in Making Recommendations from Case Series Reports 28appd.doc Microsoft Word® Document MS Word® 2002 47KB 2 pages Contents: Appendix D. Acronyms and Abbreviations __________________________________________________________________________________________________________
AHRQ Publication No. 02-E014
Current as of May 2002
Internet Citation:
Management of Clinically Inapparent Adrenal Mass. File Inventory, Evidence Report/Technology Assessment Number 56. AHRQ Publication No. 02-E014, May 2002. Agency for Healthcare Research and Quality, Rockville, MD. http://www.ahrq.gov/clinic/admasinv.htm
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