Prepared by:
MetaWorks Inc. Evidence-based Practice Center, Medford, MA
Susan D. Ross, M.D., FRCPC
Program Director
Cindy Levine, M.D.
Principal Investigator
Nelson Ganz, M.D.
Diana Frame, M.E.M.
Rhonda Estok, R.N., B.S.N.
Linda Stone, R.N., M.S., C.P.N.P.
Veronica Ludensky, B.A.
Investigators
File Name Description Software Version File Size _______________________________________________________________________________________________________ 01front.doc Microsoft Word® Document MS Word® 2002 61KB 10 pages Contents: Title Page, Preface, Acknowledgments, Structured Abstract, Table of Contents _______________________________________________________________________________________________________ 02summ.doc Microsoft Word® Document MS Word® 2002 41KB 4 pages Contents: Summary: Overview, Reporting the Evidence, Methodology, Findings, Future Research _______________________________________________________________________________________________________ 03chap1.doc Microsoft Word® Document MS Word® 2002 27KB 4 pages Contents: Chapter 1. Introduction: Purpose of Review, Prevalence and Diagnostic Criteria, Treatment of CFS, Challenges in Determining Disability _______________________________________________________________________________________________________ 04chap2.doc Microsoft Word® Document MS Word® 2002 56KB 8 pages Contents: Chapter 2. Methodology: Key Questions, Causal Pathway, Literature Search, Linked Studies, Rating the Evidence, Data Extraction, Database Development, Statistical Methods, Role of Consultants, Peer Review _______________________________________________________________________________________________________ 05fig1.doc Microsoft Word® Document MS Word® 2002 38KB 1 page Contents: Figure 1. MetaWorks systematic review process diagram _______________________________________________________________________________________________________ 06chap3.doc Microsoft Word® Document MS Word® 2002 48KB 7 pages Contents: Chapter 3. Results: Searches; Studies; Study Quality and Validity; Patients; Impairment Domains; Key Question 1: Disability and Impairment in CFS Patients; Key Question 2: Neuropsychological Tests Associated With Impairment in CFS Patients; Key Question 3: Treatments Effective in Restoring Ability to Work in CFS Patients; Key Question 4: Characteristics Associated With Improvement in CFS Patients _______________________________________________________________________________________________________ 07fig2.doc Microsoft Word® Document MS Word® 2002 24KB 1 page Contents: Figure 2. Study attrition _______________________________________________________________________________________________________ 08fig3.doc Microsoft Word® Document MS Word® 2002 21KB 1 page Contents: Figure 3. Disease severity vs. % unemployed _______________________________________________________________________________________________________ 09fig4.doc Microsoft Word® Document MS Word® 2002 21KB 1 page Contents: Figure 4. Disease severity vs. % work limitations _______________________________________________________________________________________________________ 10fig5.doc Microsoft Word® Document MS Word® 2002 26KB 1 page Contents: Figure 5. General health vs. % unemployed. _______________________________________________________________________________________________________ 11fig6.doc Microsoft Word® Document MS Word® 2002 21KB 1 page Contents: Figure 6. Physical activity vs. % unemployed _______________________________________________________________________________________________________ 12fig7.doc Microsoft Word® Document MS Word® 2002 21KB 1 page Contents: Figure 7. Mean depression score vs. % unemployed _______________________________________________________________________________________________________ 13chap4.doc Microsoft Word® Document MS Word® 2002 32KB 3 pages Contents: Chapter 4. Conclusions: Summary of Answers to Key Questions; Strengths and Limitations of the Evidence Base; Conclusions _______________________________________________________________________________________________________ 14chap5.doc Microsoft Word® Document MS Word® 2002 22KB 2 pages Contents: Chapter 5. Future Research _______________________________________________________________________________________________________ 15refs.doc Microsoft Word® Document MS Word® 2002 122KB 10 pages Contents: References, Bibliography _______________________________________________________________________________________________________ 16etbl1.xls Microsoft Excel® Worksheet MS Excel® 2002 17KB 1 page Contents: Evidence Table 1. Study characteristics _______________________________________________________________________________________________________ 17etbl2.xls Microsoft Excel® Worksheet MS Excel® 2002 16KB 1 page Contents: Evidence Table 2. Study quality and validity _______________________________________________________________________________________________________ 18etbl3.xls Microsoft Excel® Worksheet MS Excel® 2002 18KB 1 page Contents: Evidence Table 3. Patient demographics, history, and employment status _______________________________________________________________________________________________________ 19etbl4.xls Microsoft Excel® Worksheet MS Excel® 2002 17KB 1 page Contents: Evidence Table 4. Employment status and impairment domains _______________________________________________________________________________________________________ 20etbl5.xls Microsoft Excel® Worksheet MS Excel® 2002 18KB 1 page Contents: Evidence Table 5. Employment and physical impairments _______________________________________________________________________________________________________ 21etbl6.xls Microsoft Excel® Worksheet MS Excel® 2002 19KB 1 page Contents: Evidence Table 6. Neuropsychological tests and work status for CFS patients vs. healthy controls _______________________________________________________________________________________________________ 22etbl7.xls Microsoft Excel® Worksheet MS Excel® 2002 17KB 1 page Contents: Evidence Table 7. Interventions and work or impairment domains _______________________________________________________________________________________________________ 23etbl8.xls Microsoft Excel® Worksheet MS Excel® 2002 16KB 1 page Contents: Evidence Table 8. Restoring ability to work in CFS patients _______________________________________________________________________________________________________ 24etbl9.xls Microsoft Excel® Worksheet MS Excel® 2002 18KB 1 page Contents: Evidence Table 9. Baseline characteristics for CFS patients reported as improved _______________________________________________________________________________________________________ 25etbl10.xls Microsoft Excel® Worksheet MS Excel® 2002 16KB 1 page Contents: Evidence Table 10. Studies reporting work status correlation _______________________________________________________________________________________________________ 26appa.doc Microsoft Word® Document MS Word® 2002 142KB 19 pages Contents: Appendix A. Work Plan and Causal Pathway _______________________________________________________________________________________________________ 27appb.doc Microsoft Word® Document MS Word® 2002 100KB 12 pages Contents: Appendix B. Expert Meeting Information _______________________________________________________________________________________________________ 28appc.xls Microsoft Excel® Worksheet MS Excel® 2002 87KB 9 pages Contents: Appendix C. Screening and Data Extraction Forms _______________________________________________________________________________________________________ 29appd.doc Microsoft Word® Document MS Word® 2002 36KB 6 pages Contents: Appendix D. Quality Assessment Tools _______________________________________________________________________________________________________ 30appe.xls Microsoft Excel® Worksheet MS Excel® 2002 19KB 2 pages Contents: Appendix E. Scale Names and Citations _______________________________________________________________________________________________________ 31appf.doc Microsoft Word® Document MS Word® 2002 32KB 4 pages Contents: Appendix F. Technical Experts Panel and Peer Reviewers _______________________________________________________________________________________________________ 32appg.doc Microsoft Word® Document MS Word® 2002 59KB 4 pages Contents: Appendix G. Reviewer Questionnaire _______________________________________________________________________________________________________ 33apph.doc Microsoft Word® Document MS Word® 2002 42KB 7 pages Contents: Appendix H. Accepted Studies Log _______________________________________________________________________________________________________ 34appi.doc Microsoft Word® Document MS Word® 2002 114KB 33 pages Contents: Appendix I. Rejected Studies Log _______________________________________________________________________________________________________
AHRQ Publication No. 03-E007
Current as of December 2002
Internet Citation:
Systematic Review of the Current Literature Related to Disability and Chronic Fatigue Syndrome. File Inventory, Evidence Report/Technology Assessment Number 66. AHRQ Publication No. 03-E007, December 2002. Agency for Healthcare Research and Quality, Rockville, MD. http://www.ahrq.gov/clinic/cfsdisinv.htm
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