Prepared by:
The Johns Hopkins University Evidence-based Practice Center
Jodi B. Segal, M.D., M.P.H.
John Eng, M.D.
Mollie W. Jenckes, M.H.Sc., B.S.N.
Leonardo J. Tamariz, M.D., M.P.H.
Dennis T. Bolger, M.D., M.P.H.
Jerry A. Krishnan, M.D.
Michael B. Streiff, M.D.
Kirk A. Harris, B.A.
Carolyn J. Feuerstein
Eric B. Bass, M.D., M.P.H.
Investigators
File Name Description Software Version File Size ________________________________________________________________________________________________________ 01front.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 57KB 7 pages Contents: Cover, Title Page, Preface, Structured Abstract ________________________________________________________________________________________________________ 02conts.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 32KB 3 pages Contents: Table of Contents ________________________________________________________________________________________________________ 03summ.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 53KB 9 pages Contents: Summary: Overview, Reporting the Evidence, Methodology, Evidence Grades, Findings, Future Research ________________________________________________________________________________________________________ 04chap1.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 19KB 3 pages Contents: Chapter 1. Introduction: Definition of Venous Thromboembolism, Epidemiology, Etiology, Diagnostic Approaches, Therapeutic Approaches, Purpose of Evidence Report ________________________________________________________________________________________________________ 05chap2.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 93KB 8 pages Contents: Chapter 2. Methodology: Recruitment of Experts, Target Population, Identifying the Specific Questions, Key Questions, Causal Pathway, Literature Search Methods, Qualitative and Quantitative Data Abstraction, Article Review Process, Evidence Tables, Evidence Grades, Peer Review Process ________________________________________________________________________________________________________ 06chap3.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 330KB 29 pages Contents: Chapter 3. Results: Literature Search and Abstract Review, Articles Eligible for Review, Results of the Key Questions: Question 1. What are the efficacy and safety of low molecular weight heparin compared to unfractionated heparin for treatment of deep venous thrombosis? Question 2. What are the efficacy and safety of low molecular weight heparin compared to unfractionated heparin for treatment of pulmonary embolism? Question 3a. What are the efficacy and safety of outpatient versus inpatient treatment of deep venous thrombosis with low molecular weight heparin or unfractionated heparin? Question 3b. What is the cost-effectiveness of outpatient versus inpatient treatment of deep venous thrombosis with low molecular weight heparin or unfractionated heparin? Question 4. What is the optimal duration of treatment for deep venous thrombosis and pulmonary embolism in patients without known thrombophilic disorders and in patients with thrombophilic disorders? Question 5. How accurate are clinical prediction rules for the diagnosis of deep venous thrombosis or pulmonary embolism? Question 6a. What are the test characteristics of ultrasound for diagnosis of deep venous thrombosis? Question 6b. Are calf vein thromboses adequately identified with ultrasound? Question 7a. What are the test characteristics of helical computized tomography, mangnetized resonance imaging, and magnetized resonance angiography for diagnosis of pulmonary embolism relative to ventilation perfusion scanning and/or standard angiography? Question 7b. What are the test characteristics of magnetic resonance angiography and magnetized resonance angiography for diagnosis of pulmonary embolism relative to ventilation perfusion scanning and/or standard angiography? Question 8. What are the test characteristics of D-dimer for diagnosis of venous thromboembolism? ________________________________________________________________________________________________________ 07chap4.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 41KB 7 pages Contents: Chapter 4. Conclusions: Key Findings, Limitations, Implications ________________________________________________________________________________________________________ 08chap5.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 31KB 3 pages Contents: Chapter 5. Future Research ________________________________________________________________________________________________________ 09refs.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 113KB 9 pages Contents: References ________________________________________________________________________________________________________ 10etbl1.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 24KB 2 pages Contents: Evidence Table 1: Description of systematic reviews of low molecular weight heparin compared to unfractionated heparin for treatment of venous thromboembolism ________________________________________________________________________________________________________ 11etbl2.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 29KB 4 pages Contents: Evidence Table 2: Results of systematic reviews of low molecular weight heparin compared to unfractionated heparin for treatment of venous thromboembolism ________________________________________________________________________________________________________ 12etbl3.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 19KB 2 pages Contents: Evidence Table 3: Description of studies comparing outpatient to inpatient treatment of venous thromboembolism ________________________________________________________________________________________________________ 13etbl4.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 18KB 1 page Contents: Evidence Table 4: Quality of studies comparing outpatient to inpatient treatment of venous thromboembolism ________________________________________________________________________________________________________ 14etbl5.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 28KB 2 pages Contents: Evidence Table 5: Characteristics of patients in studies comparing outpatient to inpatient treatment of venous thromboembolism ________________________________________________________________________________________________________ 15etbl6.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 30KB 2 pages Contents: Evidence Table 6: Results of studies comparing outpatient to inpatient treatment of venous thromboembolism ________________________________________________________________________________________________________ 16etbl7.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 17KB 1 page Contents: Evidence Table 7: Description of modeled analysis of the costs of using low molecular weight heparin compared to unfractionated heparin for treatment of venous thromboembolism ________________________________________________________________________________________________________ 17etbl8.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 32KB 2 pages Contents: Evidence Table 8: Designs of the modeled analyses of the costs of using low molecular weight heparin compared to unfractionated heparin for treatment of venous thromboembolism ________________________________________________________________________________________________________ 18etbl9.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 18KB 2 pages Contents: Evidence Table 9: Results of the modeled analyses of the costs of using low molecular weight heparin compared to unfractionated heparin for treatment of venous thromboembolism ________________________________________________________________________________________________________ 19etbl10.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 27KB 4 pages Contents: Evidence Table 10: Description of the studies evaluating optimal duration of therapy with warfarin after venous thromboembolism ________________________________________________________________________________________________________ 20etbl11.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 19KB 1 page Contents: Evidence Table 11: Quality of the studies evaluating optimal duration of therapy with warfarin after venous thromboembolism ________________________________________________________________________________________________________ 21etbl12.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 38KB 3 pages Contents: Evidence Table 12: Characteristics of patients in studies evaluating optimal duration of therapy with warfarin after venous thromboembolism ________________________________________________________________________________________________________ 22etbl13.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 39KB 2 pages Contents: Evidence Table 13: Results of studies evaluating optimal duration of therapy with warfarin after venous thromboembolism ________________________________________________________________________________________________________ 23etbl14.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 27KB 4 pages Contents: Evidence Table 14: Description of studies evaluating clinical prediction rules used in diagnosis of venous thromboembolism ________________________________________________________________________________________________________ 24etbl15.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 20KB 2 pages Contents: Evidence Table 15: Quality of studies evaluating clinical prediction rules used in diagnosis of venous thromboembolism ________________________________________________________________________________________________________ 25etbl16.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 22KB 1 page Contents: Evidence Table 16: Characteristics of patients in studies evaluating clinical prediction rules used in diagnosis of venous thromboembolism ________________________________________________________________________________________________________ 26etbl17.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 53KB 4 pages Contents: Evidence Table 17: Results of studies evaluating clinical prediction rules used in diagnosis of venous thromboembolism ________________________________________________________________________________________________________ 27etbl18.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 19KB 1 page Contents: Table 18: Summary of systematic reviews on ultrasound in the diagnosis of deep venous thrombosis ________________________________________________________________________________________________________ 28etbl19.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 40KB 2 pages Contents: Table 19: Results of systematic reviews on ultrasound in the diagnosis of deep venous thrombosis ________________________________________________________________________________________________________ 29etbl20.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 21KB 2 pages Contents: Evidence Table 20: Description of the systematic reviews on the use of computed tomography for the diagnosis of pulmonary embolism ________________________________________________________________________________________________________ 30etbl21.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 16KB 1 page Contents: Evidence Table 21: Results of the systematic reviews on the use of computed tomography in the diagnosis of pulmonary embolism ________________________________________________________________________________________________________ 31etbl22.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 22KB 2 pages Contents: Evidence Table 22: Study design and characteristics of patients in studies evaluating computed tomography or magnetic resonance imaging for diagnosis of pulmonary embolism ________________________________________________________________________________________________________ 32etbl23.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 22KB 2 pages Contents: Evidence Table 23: Quality of studies evaluating computed tomography or magnetic resonance imaging for diagnosis of pulmonary embolism ________________________________________________________________________________________________________ 33etbl24.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 30KB 2 pages Contents: Evidence Table 24: Results of studies evaluating computed tomography or magnetic resonance imaging for diagnosis of pulmonary embolism ________________________________________________________________________________________________________ 34biblio.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 79KB 15 pages Contents: Bibliography ________________________________________________________________________________________________________ 35appa.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 20KB 1 page Contents: Appendix A. Core Technical Experts and Peer Reviewers ________________________________________________________________________________________________________ 36appb.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 10KB 1 page Contents: Appendix B. Priority Journals for Hand Searching ________________________________________________________________________________________________________ 37appc.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 19KB 2 pages Contents: Appendix C. Literature Search Strategies ________________________________________________________________________________________________________ 38appd.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 28KB 1 page Contents: Appendix D. Abstract Review for Primary Literature ________________________________________________________________________________________________________ 39appe.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 10KB 1 page Contents: Appendix E. Abstract Review for Systematic Reviews ________________________________________________________________________________________________________ 40appf.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 33KB 6 pages Contents: Appendix F. Quality Review for Key Questions 3 and 4 ________________________________________________________________________________________________________ 41appg.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 41KB 5 pages Contents: Appendix G. Quality Review for Key Questions 5 and 7 ________________________________________________________________________________________________________ 42apph.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 35KB 4 page Contents: Appendix H. Quality Review for Key Question 3b (costs) ________________________________________________________________________________________________________ 43appi.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 29KB 3 pages Contents: Appendix I. Quality Review for Systematic Review ________________________________________________________________________________________________________ 44appj.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 22KB 3 pages Contents: Appendix J. Acronyms and Abbreviations ________________________________________________________________________________________________________ 45appk.wpd Corel WordPerfect® Document Corel WordPerfect® 6/7/8/9/10 3KB 1 page Contents: Appendix K. Acknowledgements ________________________________________________________________________________________________________
AHRQ Publication No. 03-E016
Current as of March 2003
Internet Citation:
Diagnosis and Treatment of Deep Venous Thrombosis and Pulmonary Embolism. File Inventory, Evidence Report/Technology Assessment Number 68. AHRQ Publication No. 03-E016, March 2003. Agency for Healthcare Research and Quality, Rockville, MD. http://www.ahrq.gov/clinic/dvtinv.htm
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