Evidence Report/Technology Assessment Number 70

Criteria for Determining Disability in Infants and Children: Low Birth Weight

Volume 1. Evidence Report and Appendixes
Volume 2. Evidence Tables

File Inventory


Prepared by:

Tufts New England Medical Center EPC
Boston, MA

Principal Investigator
   Cynthia Cole, M.D., M.P.H.
Investigators
   Geoffrey Binney, M.D., M.P.H.
   Patricia Casey, R.N.C., M.S., N.N.P.
   John Fiascone, M.D.
   James Hagadorn, M.D.
   Chiwan Kim, M.D.
EPC Staff
   Joseph Lau, M.D., Director
   Chenchen Wang, M.D., M.Sc., Project Leader
   Deirdre DeVine, M.Litt., Project Manager
   Kimberly Miller, B.A., Research Assistant


File Name	Description			Software	Version		File	Size
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01front1.doc	Microsoft Word® Document	MS Word®	2002		165KB	13 pages
Contents: Volume 1 Title Page, Preface, Acknowledgments, Structured Abstract, Table of Contents
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02summ.doc	Microsoft Word® Document	MS Word®	2002		76KB	11 pages
Contents: Summary: Overview, Reporting the Evidence, Findings, Future Research
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03chap1.doc	Microsoft Word® Document	MS Word®	2002		62KB	6 pages
Contents: Chapter 1. Introduction: Definition of Disability; Definition of Prematurity; 
The Problem of Prematurity; Table A. Live birth distribution organized by birth weight and 
gestation in the United States in the year 2000; Table B. Mortality and Morbidity of 
Premature Infants by Birth Weight Born in NICHD Neonatal Research Network Between January 1, 
1993 and December 31, 1994; Factors Associated with Disability in VLBW Infants
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04chap2.doc	Microsoft Word® Document	MS Word®	2002		141KB	10 pages
Contents: Chapter 2. Methods: Key Questions Addressed by the Evidence Report; Literature Search 
Strategies; Study Selection; Table C. Inclusion/exclusion criteria; Outcomes and Predictors 
Considered in this Evidence Report; Table D. List of predictors and outcomes; Reporting the 
Evidence; Table E. Evidence tables created in this report; Summarizing the Evidence of 
Individual Studies
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05chap3a.doc	Microsoft Word® Document	MS Word®	2002		599KB	48 pages
Contents: Chapter 3. Results: 

Evidence that VLBW With or Without Other Conditions is Associated With Cerebral Palsy (CP) and 
Neurologic Disability; Table 1.1a. Association of Cerebral Palsy with VLBW/Prematurity; 
Table 1.1b. Association of Cerebral Palsy with LBW / Prematurity; Table 1.2a. Association of 
Cerebral Palsy by Degree of Immaturity; Table 1.3a. Association of CP and neurologic abnormalities 
in VLBW with CNS injury; Table 1.3b. Association of CP and neurologic abnormalities with 
antenatal risk factors in VLBW infants; Table 1.3c. Association of CP and neurologic abnormalities 
in VLBW with BPD and BPD and postnatal systemic glucocorticoid therapy; Table 1.3d. Association 
of CP and neurologic abnormalities in VLBW infants parenting / psychosocial risk factors; 
Table 1.3e. Association of CP and neurologic abnormalities in VLBW plus other factors; 

Evidence That VLBW With Or Without Other Conditions Is Associated With Abnormal Cognitive 
Development And MR; Table 2.1. Representative ability test scores defining significantly delayed 
or deficient cognitive development/mental retardation; Table 2.2. Incidence of Mental Retardation 
in VLBW / ELBW Infants; Table 2.3. Changes in incidence of MR with time in LBW infants; 
Table 2.4. Association of Mental Retardation / Disability to Independent Risk Factors in LBW 
infants; Table 2.5. Association of Mental Retardation / Disability with other Risk Factors in 
LBW infants;

Evidence That VLBW Is Associated With Disabilities Of Speech/Language Delay, Hearing Loss, 
Behavioral Disorders, And Learning Disabilities; 
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06chap3b.doc	Microsoft Word® Document	MS Word®	2002		677KB	53 pages
Contents: Chapter 3. Results: 
Evidence That VLBW Is Associated With Disabilities Of Speech/Language Delay, Hearing Loss, 
Behavioral Disorders, And Learning Disabilities (continued); Table 3.1. Association of LBW 
to Speech and Language Disorders; Table 3.2. Association of VLBW with Hearing Loss; 
Table 3.3. Association of LBW to Behavior Outcomes; Table 3.4.  Association of LBW to 
Learning Disability and School Performance; 

Evidence That VLBW With Or Without Other Conditions Is Associated With Visual Disability; 
Table 4.1. Association of VLBW/Prematurity with Ophthalmology Outcomes; Table 4.2a. Visual 
disability related to increasing severity of ROP in VLBW infants; Table 4.2b. Proportion of 
eyes with unfavorable visual function; Table 4.3. Unfavorable functional outcome in eyes with 
threshold ROP by randomized treatment assignment (cryotherapy vs. no cryotherapy) during 
1, 3.5, 5.5, and 10-year follow-up; Table 4.4. Visual disability related to severe (threshold) 
ROP; Table 4.5. Evidence that VLBW infants with CNS abnormality have visual disability (with 
no or mild ROP); Table 4.6. VLBW and/or ROP and/or CNS injury are positively associated with 
refractive error (myopia) and ocular motility (strabismus); Table 4.7. Abnormal visual function 
due to fixation instability (nystagmus and strabismus) in VLBW infants; Table 4.8. Association 
between VLBW plus bronchopulmonary dysplasia (BPD) and systemic glucocorticosteroid therapy for 
bronchopulmonary dysplasia with visual disability; 

Evidence That VLBW With Or Without Other Conditions Is Associated With Pulmonary Disability; 
Table 5.1. Percent of infants with BPD* in Relation to Birth Weight in the Vermont Oxford Neonatal 
Network; Table 5.2a. VLBW with BPD is associated with long-term pulmonary morbidity and disability 
by 1-2 year of follow-up; Table 5.2b. VLBW with BPD is associated with long-term pulmonary disability 
by 3 years of follow-up; Table 5.2c. VLBW with BPD is associated with long-term pulmonary disability 
by 6-12 year of follow-up; Table 5.2d. VLBW with BPD is associated with long-term pulmonary disability 
by 12-16 year of follow-up; Table 5.3. Association of VLBW/Prematurity with asthma or hyper-reactive 
airway disease; Table 5.4. Association of VLBW/Prematurity with rehospitalization for respiratory 
illness: pulmonary outcomes; 

Evidence That VLBW With Or Without Other Conditions Is Associated With Growth Impairment; 
Table 6.1. Association of VLBW/Prematurity with Growth Impairment; 
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07chap3c.doc	Microsoft Word® Document	MS Word®	2002		115KB	5 pages
Contents: Contents: Chapter 3. Results: 
Evidence That VLBW With Or Without Other Conditions Is Associated With Growth Impairment 
(continued); Table 6.2. Association of VLBW plus BPD with Growth impairment; Table 6.3. Association 
of VLBW plus antenatal glucocorticoid exposure growth impairment; Table 6.4. Association of VLBW 
plus necrotizing enterocolitis exposure growth impairment; Table  6.5.  Association of VLBW plus 
postnatal nutrition with growth impairment; Table 6.6. Association of LBW/Prematurity to Growth Delay
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08chap4.doc	Microsoft Word® Document	MS Word®	2002		39KB	5 pages
Contents: Chapter 4. Conclusions: Overall; Neurodevelopmental Disabilities; Speech and Language; 
Visual Disability; Pulmonary Disability; Poor Growth
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09chap5.doc	Microsoft Word® Document	MS Word®	2002		32KB	3 pages
Contents: Chapter 5. Future Research: Evaluation of the Application Process of SSA VLBW Disability 
Criteria; Determine the Appropriateness of the New VLBW Disability Criteria Proposed by SSA 
Based on the Evidence of this Report; Proposal to Improve the Evidence of Predictors and 
Predictive Models; Feasibility of Future Research Proposals
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10refs.doc	Microsoft Word® Document	MS Word®	2002		90KB	12 pages
Contents: References/Bibliography
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11appa.doc	Microsoft Word® Document	MS Word®	2002		110KB	7 pages
Contents: Appendix A. Search Strategies
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12appb.doc	Microsoft Word® Document	MS Word®	2002		169KB	11 pages
Contents: Appendix B. Data Abstraction Form
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13appc.doc	Microsoft Word® Document	MS Word®	2002		50KB	2 pages
Contents: Appendix C. Acronyms and Abbreviations
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14appd.doc	Microsoft Word® Document	MS Word®	2002		36KB	3 pages
Contents: Appendix D. Acknowledgements
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15front2.doc	Microsoft Word® Document	MS Word®	2002		36KB	4 pages
Contents: Volume 2 Title Page, Table of Contents
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16etbl1.doc	Microsoft Word® Document	MS Word®	2002		722KB	94 pages
Contents: Evidence Table 1. Studies Evaluating Association of LBW and Multiple Outcomes: 
CNS, Eye, Lung, Growth, etc
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17etbl2.doc	Microsoft Word® Document	MS Word®	2002		82KB	9 pages
Contents: Evidence Table 2. Randomized Controlled Trials for LBW Infants and Multiple Outcomes: 
CNS, Eye, Lung, Growth
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18etbl3.doc	Microsoft Word® Document	MS Word®	2002		808KB	95 pages
Contents: Evidence Table 3. Studies Evaluating Association of LBW and Cerebral Palsy and 
Neurological Outcomes
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19etbl4.doc	Microsoft Word® Document	MS Word®	2002		106KB	14 pages
Contents: Evidence Table 4. Studies Evaluating Treatment Effects of LBW and Cerebral Palsy and 
Neurological Outcomes
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20etbl5a.doc	Microsoft Word® Document	MS Word®	2002		115KB	17 pages
Contents: Evidence Table 5A. Studies Evaluating Association of LBW to Speech and Language 
Disorders
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21etbl5b.doc	Microsoft Word® Document	MS Word®	2002		264KB	37 pages
Contents: Evidence Table 5B. Studies Evaluating Association of LBW to Audiology Outcomes
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22etbl6a.doc	Microsoft Word® Document	MS Word®	2002		103KB	12 pages
Contents: Evidence Table 6A. Studies Evaluating Association of LBW to Behavioral Disorders
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23etbl6b.doc	Microsoft Word® Document	MS Word®	2002		61KB	5 pages
Contents: Evidence Table 6B. Studies Evaluating Association of LBW to School Performance and 
Learning Disabilities
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24etbl7.doc	Microsoft Word® Document	MS Word®	2002		106KB	11 pages
Contents: Evidence Table 7. Studies Evaluating Association of LBW to Ophthalmologic Outcomes
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25etbl8.doc	Microsoft Word® Document	MS Word®	2002		143KB	12 pages
Contents: Evidence Table 8. Studies of Treatment Effects for LBW Infants With Retinopathy of 
Prematurity (ROP)
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26etbl9.doc	Microsoft Word® Document	MS Word®	2002		189KB	20 pages
Contents: Evidence Table 9. Studies Evaluating Association of LBW and Pulmonary Outcomes
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27etbl10.doc	Microsoft Word® Document	MS Word®	2002		155KB	15 pages
Contents: Evidence Table 10. Studies Evaluating Association of LBW and Bone and Growth Outcomes
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28etbl11.doc	Microsoft Word® Document	MS Word®	2002		50KB	4 pages
Contents: Evidence Table 11. Randomized Controlled Trials in LBW Neonates for Growth Outcomes
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29etbl12.doc	Microsoft Word® Document	MS Word®	2002		54KB	1 page
Contents: Evidence Table 12. Studies Evaluating Association of LBW and Nutritional Outcomes
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30etbl13.doc	Microsoft Word® Document	MS Word®	2002		90KB	8 pages
Contents: Evidence Table 13. Studies Evaluating Association of LBW and Other Outcomes
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AHRQ Publication No. 03-E010
Current as of December 2002


Internet Citation:

Criteria for Determining Disability in Infants and Children: Low Birth Weight. File Inventory, Evidence Report/Technology Assessment Number 70. AHRQ Publication No. 03-E010, December 2002. Agency for Healthcare Research and Quality, Rockville, MD. http://www.ahrq.gov/clinic/lbwinv.htm


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