Prepared by:
Duke Evidence-based Practice Center, Durham, North Carolina
Investigators
Douglas C. McCrory, M.D., M.H.S.
Lisa A. Pompeii, Ph.D., COHN-S
Mark B. Skeen, M.D.
Sam D. Moon, M.D., M.P.H.
Rebecca N. Gray, D.Phil.
Jane T. Kolimaga, M.A.
David B. Matchar, M.D.
File Name Description Software Version File Size _________________________________________________________________________________________________________ 01front.doc Microsoft Word® Document MS Word® 2002 42KB 6 pages Contents: Title Page, Preface _________________________________________________________________________________________________________ 02abstr.doc Microsoft Word® Document MS Word® 2002 23KB 1 page Contents: Structured Abstract _________________________________________________________________________________________________________ 03conts.doc Microsoft Word® Document MS Word® 2002 28KB 3 pages Contents: Table of Contents _________________________________________________________________________________________________________ 04chap1.doc Microsoft Word® Document MS Word® 2002 44KB 6 pages Contents: Chapter 1. Introduction: Purpose, Background, Research Questions, Limitations of Report _________________________________________________________________________________________________________ 05chap2.doc Microsoft Word® Document MS Word® 2002 37KB 4 pages Contents: Chapter 2. Methods: Literature Search and Review, Data Abstraction and Development of Evidence Tables, Quality Assessment Criteria, Peer Review Process _________________________________________________________________________________________________________ 06tbl1.doc Microsoft Word® Document MS Word® 2002 26KB 1 page Contents: Table 1. Results of title-and-abstract screening and full-text article review _________________________________________________________________________________________________________ 07tbl2.doc Microsoft Word® Document MS Word® 2002 32KB 1 page Contents: Table 2. Included full-text articles by research question _________________________________________________________________________________________________________ 08chap3.doc Microsoft Word® Document MS Word® 2002 394KB 23 pages Contents: Chapter 3. Results: Diagnostic Reliability of McDonald Criteria; Inter-rater Reliability of Diagnosis with McDonald and Poser criteria; Predictors of Physical and Mental Impairments at 12 Months; Disease-modifying Therapies and Long-term Improvement; Symptom Management and Improvement; Association of Clinical Findings with Work Ability; Environmental Factors and Work Ability _________________________________________________________________________________________________________ 09fig1.doc Microsoft Word® Document MS Word® 2002 25KB 1 page Contents: Figure 1. Temporal relationship of pre-disability evaluation and occurrence of work disability _________________________________________________________________________________________________________ 10tbl3.doc Microsoft Word® Document MS Word® 2002 127KB 2 pages Contents: Table 3. Data supporting the validity of MRI components of the McDonald criteria _________________________________________________________________________________________________________ 11tbl4.doc Microsoft Word® Document MS Word® 2002 29KB 1 page Contents: Table 4. Studies validating the McDonald criteria _________________________________________________________________________________________________________ 12tbl5.doc Microsoft Word® Document MS Word® 2002 26KB 1 page Contents: Table 5. Kappa statistics for multiple raters using Poser and McDonald criteria _________________________________________________________________________________________________________ 13tbl6.doc Microsoft Word® Document MS Word® 2002 128KB 1 page Contents: Table 6. Relapse rate outcomes from placebo-controlled RCTs of disease-modifying therapies _________________________________________________________________________________________________________ 14tbl7.doc Microsoft Word® Document MS Word® 2002 123KB 1 page Contents: Table 7. Improvements in physical function (EDSS) in placebo-controlled RCTs of disease-modifying therapies _________________________________________________________________________________________________________ 15tbl8.doc Microsoft Word® Document MS Word® 2002 188KB 4 pages Contents: Table 8. Randomized controlled trials of symptomatic treatments for spasticity _________________________________________________________________________________________________________ 16tbl9.doc Microsoft Word® Document MS Word® 2002 118KB 2 pages Contents: Table 9. Randomized controlled trials of rehabilitation interventions _________________________________________________________________________________________________________ 17tbl10.doc Microsoft Word® Document MS Word® 2002 41KB 1 page Contents: Table 10. Randomized controlled trials of treatments for depression _________________________________________________________________________________________________________ 18tbl11.doc Microsoft Word® Document MS Word® 2002 36KB 1 page Contents: Table 11. Randomized controlled trials of treatments for fatigue _________________________________________________________________________________________________________ 19tbl12.doc Microsoft Word® Document MS Word® 2002 36KB 1 page Contents: Table 12. Randomized controlled trials of treatments for voiding dysfunction _________________________________________________________________________________________________________ 20tbl13.doc Microsoft Word® Document MS Word® 2002 106KB 1 page Contents: Table 13. Included studies by type of measure used and type of function considered (physical, mental, other) _________________________________________________________________________________________________________ 21tbl14.doc Microsoft Word® Document MS Word® 2002 37KB 2 pages Contents: Table 14. Studies by Rozin et al. measuring ability to work among individuals with MS _________________________________________________________________________________________________________ 22tbl15.doc Microsoft Word® Document MS Word® 2002 29KB 1 page Contents: Table 15. Cross-sectional studies examining current employment status and EDSS level among individuals with MS _________________________________________________________________________________________________________ 23tbl16.doc Microsoft Word® Document MS Word® 2002 36KB 2 pages Contents: Table 16. Cognitive function and work status among individuals with MS _________________________________________________________________________________________________________ 24tbl17.doc Microsoft Word® Document MS Word® 2002 39KB 2 pages Contents: Table 17. Job type/characteristics and current work status among individuals with MS _________________________________________________________________________________________________________ 25tbl18.doc Microsoft Word® Document MS Word® 2002 34KB 2 pages Contents: Table 18. Self-report on why individuals with MS continued or terminated employment _________________________________________________________________________________________________________ 26tbl19.doc Microsoft Word® Document MS Word® 2002 33KB 1 page Contents: Table 19. Conditions/situations impeding or enhancing performance of work/chores _________________________________________________________________________________________________________ 27chap4.doc Microsoft Word® Document MS Word® 2002 144KB 12 pages Contents: Chapter 4. Discussion: Discussion of Evidence, Knowledge Gaps and Future Research Recommendations _________________________________________________________________________________________________________ 28refs.doc Microsoft Word® Document MS Word® 2002 143KB 10 pages Contents: References Cited in the Evidence Report _________________________________________________________________________________________________________ 29stincl.doc Microsoft Word® Document MS Word® 2002 62KB 7 pages Contents: Listing of Included Studies _________________________________________________________________________________________________________ 30stexcl.doc Microsoft Word® Document MS Word® 2002 187KB 25 pages Contents: Listing of Excluded Studies _________________________________________________________________________________________________________ 31abbr.doc Microsoft Word® Document MS Word® 2002 22KB 1 page Contents: List of Acronyms/Abbreviations _________________________________________________________________________________________________________ 32appa.doc Microsoft Word® Document MS Word® 2002 52KB 8 pages Contents: Appendix A. Excerpts from: Social Security Administration Office of Disability. Disability Evaluation Under Social Security, 2003. SSA Pub. No. 64-039. Social Security Administration: Baltimore, MD _________________________________________________________________________________________________________ 33appb.doc Microsoft Word® Document MS Word® 2002 37KB 3 pages Contents: Appendix B. Search Strategies _________________________________________________________________________________________________________ 34appc.doc Microsoft Word® Document MS Word® 2002 30KB 2 pages Contents: Appendix C. Instructions for Title and Abstract Screening _________________________________________________________________________________________________________ 35appd.doc Microsoft Word® Document MS Word® 2002 34KB 3 pages Contents: Appendix D. Decision Rules for Full-text Screening _________________________________________________________________________________________________________ 36appe.doc Microsoft Word® Document MS Word® 2002 125KB 10 pages Contents: Appendix E. Evidence Table/Data Abstraction Templates _________________________________________________________________________________________________________ 37et1a.doc Microsoft Word® Document MS Word® 2002 150KB 10 pages Contents: Appendix F. Evidence Tables: Evidence Table 1a. Diagnostic reliability of McDonald criteria _________________________________________________________________________________________________________ 38et1b.doc Microsoft Word® Document MS Word® 2002 53KB 2 pages Contents: Appendix F. Evidence Tables: Evidence Table 1b. Inter-rater reliability of diagnosis with McDonald and Poser criteria _________________________________________________________________________________________________________ 39et2.doc Microsoft Word® Document MS Word® 2002 160KB 11 pages Contents: Appendix F. Evidence Tables: Evidence Table 2. Predictors of physical and mental impairments at 12 months _________________________________________________________________________________________________________ 40et3a.doc Microsoft Word® Document MS Word® 2002 451KB 41 pages Contents: Appendix F. Evidence Tables: Evidence Table 3a. Disease-modifying therapies and long-term improvement _________________________________________________________________________________________________________ 41et3bam.doc Microsoft Word® Document MS Word® 2002 395KB 35 pages Contents: Appendix F. Evidence Tables: Evidence Table 3b. Symptom management and improvement _________________________________________________________________________________________________________ 42et3bnz.doc Microsoft Word® Document MS Word® 2002 347KB 32 pages Contents: Appendix F. Evidence Tables: Evidence Table 3b. Symptom management and improvement (continued) _________________________________________________________________________________________________________ 43et4.doc Microsoft Word® Document MS Word® 2002 285KB 26 pages Contents: Appendix F. Evidence Tables: Evidence Table 4. Association of clinical findings with work ability _________________________________________________________________________________________________________ 44et5.doc Microsoft Word® Document MS Word® 2002 285KB 2 pages Contents: Appendix F. Evidence Tables: Evidence Table 5. Environmental factors and work ability _________________________________________________________________________________________________________ 45etrefs.doc Microsoft Word® Document MS Word® 2002 62KB 7 pages Contents: Appendix F. Evidence Tables: References Cited in the Evidence Tables _________________________________________________________________________________________________________ 46etabbr.doc Microsoft Word® Document MS Word® 2002 31KB 4 pages Contents: Appendix F. Evidence Tables: Acronyms/Abbreviations Used in the Evidence Tables _________________________________________________________________________________________________________
AHRQ Publication No. 04-E019-2
Current as of May 2004
Internet Citation:
Criteria to Determine Disability Related to Multiple Sclerosis. File Inventory, Evidence Report/Technology Assessment Number 100. AHRQ Publication No. 04-E019-2, May 2004. Agency for Healthcare Research and Quality, Rockville, MD. http://www.ahrq.gov/clinic/msdisinv.htm
Return to Evidence-based Practice
Clinical Information
AHRQ Home Page
Department of Health and Human Services