Prepared by:
Southern California Evidence-based Practice Center
EPC Director
Paul Shekelle, M.D., Ph.D.
Principal Investigators
Glenn Takata, M.D.
Linda S. Chan, Ph.D.
Investigators
Rita Mangione-Smith, M.D.
Pamela M. Corley, MSLS
Tricia Morphew, M.S.
Sally Morton, Ph.D.
File Name Description Software Version File Size ________________________________________________________________________________________________ 01front1.doc Microsoft Word® Document MS Word® 2002 89KB 11 pages Contents: Title Page, Preface, Structured Abstract, Table of Contents ________________________________________________________________________________________________ 02summ.doc Microsoft Word® Document MS Word® 2002 49KB 6 pages Contents: Summary: Overview, Reporting the Evidence, Methodology, Findings, Limitations of the Literature, Future Research ________________________________________________________________________________________________ 03chap1.doc Microsoft Word® Document MS Word® 2002 48KB 8 pages Contents: Chapter 1. Introduction: Chapter 1. Introduction, Purpose, Scope of Work, Definition, Diagnosis, Epidemiology: Prevalence and Incidence, Burden of Illness Due to Otitis Media With Effusion ________________________________________________________________________________________________ 04chap2.doc Microsoft Word® Document MS Word® 2002 134KB 17 pages Contents: Chapter 2. Methodology: Nomination of Technical Experts; Topic Assessment and Refinement; Identification of Key Questions; Identification and Refinement of Causal Pathways, Study Populations, Practice Settings, and Target Audience; Literature Search; Review and Assessment of Study Quality; Data Abstraction; Procedures to Reduce Bias, Enhance Consistency, and Check Accuracy; Preparation of Evidence Tables; Supplemental Analysis; Identification of Peer Reviewers; Peer Review Process ________________________________________________________________________________________________ 05tbl1.doc Microsoft Word® Document MS Word® 2002 24KB 1 page Contents: Table 1. Technical Expert Panel ________________________________________________________________________________________________ 06tbl2.doc Microsoft Word® Document MS Word® 2002 25KB 1 page Contents: Table 2. Questions Suggested for Consideration in Evidence Report ________________________________________________________________________________________________ 07tbl3.doc Microsoft Word® Document MS Word® 2002 65KB 1 page Contents: Table 3. Ranking of Potential Key Questions ________________________________________________________________________________________________ 08tbl4.doc Microsoft Word® Document MS Word® 2002 52KB 4 pages Contents: Table 4. Comments from Technical Expert Panel on Potential Key Questions ________________________________________________________________________________________________ 09tbl5.doc Microsoft Word® Document MS Word® 2002 32KB 1 page Contents: Table 5. Overall Causal Pathway for OME ________________________________________________________________________________________________ 10tbl6.doc Microsoft Word® Document MS Word® 2002 33KB 1 page Contents: Table 6. Causal Pathway for Key Question 1 on Natural History ________________________________________________________________________________________________ 11tbl7.doc Microsoft Word® Document MS Word® 2002 38KB 1 page Contents: Table 7. Causal Pathway for Key Question 2 on Speech and Language ________________________________________________________________________________________________ 12tbl8.doc Microsoft Word® Document MS Word® 2002 30KB 1 page Contents: Table 8. Causal Pathway for Key Question 3 on Hearing ________________________________________________________________________________________________ 13tbl9.doc Microsoft Word® Document MS Word® 2002 37KB 1 page Contents: Table 9. Causal Pathway for Key Question 4 on Diagnostic Methods ________________________________________________________________________________________________ 14tbl10.doc Microsoft Word® Document MS Word® 2002 125KB 4 pages Contents: Table 10. Ranking of Influencing Factors by Technical Experts ________________________________________________________________________________________________ 15tbl11.doc Microsoft Word® Document MS Word® 2002 29KB 1 page Contents: Table 11. Reason for Rejection of Titles/Abstracts at Initial Screeng (N=3,200) ________________________________________________________________________________________________ 16tbl12.doc Microsoft Word® Document MS Word® 2002 40KB 1 page Contents: Table 12. Reason for Rejection of Full-Length Articles at Secondary Review ________________________________________________________________________________________________ 17tbl13.doc Microsoft Word® Document MS Word® 2002 34KB 1 page Contents: Table 13. Results of Secondary Screening of Full-Length Articles ________________________________________________________________________________________________ 18tbl14.doc Microsoft Word® Document MS Word® 2002 27KB 1 page Contents: Table 14. Results of Tertiary Screening of Full-Length Articles for Analysis ________________________________________________________________________________________________ 19tbl15.doc Microsoft Word® Document MS Word® 2002 27KB 1 page Contents: Table 15. Peer Review Panel ________________________________________________________________________________________________ 20tbl16.doc Microsoft Word® Document MS Word® 2002 21KB 1 page Contents: Table 16. Instructions for Reviewing Draft Evidence Report ________________________________________________________________________________________________ 21chap3.doc Microsoft Word® Document MS Word® 2002 77KB 11 pages Contents: Chapter 3. Results: Key Question 1, Key Question 2, Key Question 3, Key Question 4 ________________________________________________________________________________________________ 22tbl17.doc Microsoft Word® Document MS Word® 2002 52KB 2 pages Contents: Table 17. Cohorts and Articles Relevant to Question 1 (n=40) ________________________________________________________________________________________________ 23tbl18.doc Microsoft Word® Document MS Word® 2002 35KB 1 page Contents: Table 18. Disposition of Articles From Rosenfeld's Natural History Assessment ________________________________________________________________________________________________ 24tbl19.doc Microsoft Word® Document MS Word® 2002 32KB 1 page Contents: Table 19. Question 1: Articles Excluded During Data Abstraction ________________________________________________________________________________________________ 25tbl20.doc Microsoft Word® Document MS Word® 2002 51KB 1 page Contents: Table 20. Study Quality for Studies Included in Evidence Table on Natural History ________________________________________________________________________________________________ 26tbl21.doc Microsoft Word® Document MS Word® 2002 95KB 2 pages Contents: Table 21. Tympanometry Definitions in Natural History Cohorts Utilizing Tympanometry as the Sole Diagnostic Method ________________________________________________________________________________________________ 27tbl22.doc Microsoft Word® Document MS Word® 2002 80KB 3 pages Contents: Table 22. OME Resolution by Ears in Newly Diagnosed OME of Unknown Duration ________________________________________________________________________________________________ 28tbl23.doc Microsoft Word® Document MS Word® 2002 48KB 1 page Contents: Table 23. OME Resolution by Child on Newly Diagnosed OME of Unknown Duration ________________________________________________________________________________________________ 29tbl24.xls Microsoft Excel® Worksheet MS Excel® 2002 18KB 1 page Contents: Table 24. Meta-Analysis for <6 Weeks Resolution Rate for Newly Diagnosed OME of Unknown Duration in Children Older Than 3 Years of Age ________________________________________________________________________________________________ 30tbl25.xls Microsoft Excel® Worksheet MS Excel® 2002 18KB 1 page Contents: Table 25. Meta-Analysis for <3 Months Cumulative Resolution Rate for Newly Diagnosed OME of Unknown Duration in Children Older Than 3 Years of Age ________________________________________________________________________________________________ 31tbl26.doc Microsoft Word® Document MS Word® 2002 45KB 1 page Contents: Table 26. List of Cohort Studies Included for Question 2 ________________________________________________________________________________________________ 32tbl27.doc Microsoft Word® Document MS Word® 2002 47KB 1 page Contents: Table 27. List of Cohort Studies Not Included for Question 2 ________________________________________________________________________________________________ 33tbl28.doc Microsoft Word® Document MS Word® 2002 71KB 6 pages Contents: Table 28. Definition of Early Life Positive or Negative OM History in Assessing Long-term Speech and Language Development ________________________________________________________________________________________________ 34tbl29.doc Microsoft Word® Document MS Word® 2002 39KB 1 page Contents: Table 29. Study Quality for Studies Included in Evidence Table on Speech and Language Development ________________________________________________________________________________________________ 35tbl30.doc Microsoft Word® Document MS Word® 2002 100KB 4 pages Contents: Table 30. Key Characteristics of the Cohort Studies for Question 2 ________________________________________________________________________________________________ 36tbl31.doc Microsoft Word® Document MS Word® 2002 33KB 1 page Contents: Table 31. Meta-Analysis for Expressive Language Development ________________________________________________________________________________________________ 37tbl32.doc Microsoft Word® Document MS Word® 2002 34KB 1 page Contents: Table 32. Meta-Analysis for Receptive Language Development ________________________________________________________________________________________________ 38t33-34.doc Microsoft Word® Document MS Word® 2002 38KB 1 page Contents: Table 33. Meta-Analysis for Cognitive Verbal Intelligence; Table 34. Cohort Studies at Tertiary Screening and Reasons for Exclusion ________________________________________________________________________________________________ 39t35-36.doc Microsoft Word® Document MS Word® 2002 44KB 1 page Contents: Table 35. List of Cohort Studies Included for Question 3; Table 36. List of Cohort Studies Excluded from Question 3 ________________________________________________________________________________________________ 40tbl37.doc Microsoft Word® Document MS Word® 2002 44KB 3 pages Contents: Table 37. Definition of Early Life Positive or Negative OM History in Assessing Long-term Hearing Development ________________________________________________________________________________________________ 41tbl38.doc Microsoft Word® Document MS Word® 2002 30KB 1 page Contents: Table 38. Study Quality for Studies Included in Evidence Table on Hearing ________________________________________________________________________________________________ 42tbl39.doc Microsoft Word® Document MS Word® 2002 40KB 1 page Contents: Table 39. Characteristics and Outcome Measures of Cohort Studies for Question 3 ________________________________________________________________________________________________ 43tbl40.xls Microsoft Excel® Worksheet MS Excel® 2002 18KB 1 page Contents: Table 40. Meta-Analysis for Effects of Early Life Otitis Media on Long-term Conductive Hearing Loss ________________________________________________________________________________________________ 44tbl41.doc Microsoft Word® Document MS Word® 2002 56KB 1 page Contents: Table 41. List of Cohort Studies Included for Question 4 ________________________________________________________________________________________________ 45tbl42.doc Microsoft Word® Document MS Word® 2002 43KB 1 page Contents: Table 42. Reason for Exclusion of Diagnostic Studies After Full-Length Article Review ________________________________________________________________________________________________ 46tbl43.doc Microsoft Word® Document MS Word® 2002 35KB 1 page Contents: Table 43. Number of Articles by Diagnostic Method and Reference Standard ________________________________________________________________________________________________ 47t44-45.xls Microsoft Excel® Worksheet MS Excel® 2002 19KB 1 page Contents: Table 44. Acoustic Reflectometry versus Myringotomy; Table 45. Pneumatic Otoscopy versus Myringotomy ________________________________________________________________________________________________ 48t46-47.xls Microsoft Excel® Worksheet MS Excel® 2002 19KB 1 page Contents: Table 46. Portable Tympanometry versus Myringotomy; Table 47. Professional Tympanometry (Acoustic Reflex at 500 or 1000 Hz) versus Myringotomy ________________________________________________________________________________________________ 49tbl48.xls Microsoft Excel® Worksheet MS Excel® 2002 18KB 1 page Contents: Table 48. Professional Tympanometry (Static Compensated Acoustic Admittance at 0.1) versus Myringotomy ________________________________________________________________________________________________ 50tbl49.xls Microsoft Excel® Worksheet MS Excel® 2002 18KB 1 page Contents: Table 49. Professional Tympanometry (Static Compensated Acoustic Admittance at 0.2) versus Myringotomy ________________________________________________________________________________________________ 51tbl50.xls Microsoft Excel® Worksheet MS Excel® 2002 18KB 1 page Contents: Table 50. Professional Tympanometry (Static Compensated Acoustic Admittance at 0.3) versus Myringotomy ________________________________________________________________________________________________ 52tbl51.xls Microsoft Excel® Worksheet MS Excel® 2002 19KB 1 page Contents: Table 51. Professional Tympanometry (B curve as abnormal) versus Myringotomy ________________________________________________________________________________________________ 53tbl52.xls Microsoft Excel® Worksheet MS Excel® 2002 16KB 1 page Contents: Table 52. Professional Tympanometry (B or C2 curve as abnormal) versus Myringotomy ________________________________________________________________________________________________ 54tbl53.xls Microsoft Excel® Worksheet MS Excel® 2002 36KB 1 page Contents: Table 53. Summary of Meta Analysis for Diagnostic Comparisons, Excluding Duplicated Studies by Same Author ________________________________________________________________________________________________ 55tbl54.doc Microsoft Word® Document MS Word® 2002 45KB 2 pages Contents: Table 54. Study Quality and Test Performer of Diagnostic Studies Used in Meta-Analysis ________________________________________________________________________________________________ 56tbl55.doc Microsoft Word® Document MS Word® 2002 48KB 1 page Contents: Table 55. Country of Origin of Studies Included in Evidence Tables ________________________________________________________________________________________________ 57fig1.doc Microsoft Word® Document MS Word® 2002 41KB 1 page Contents: Figure 1. Shrinkage Plot for Rate Difference in Conductive Hearing Loss at 6-10 Years: Presence of Early Life OM versus Absence of Early Life OM ________________________________________________________________________________________________ 58fig2.doc Microsoft Word® Document MS Word® 2002 34KB 1 page Contents: Figure 2. Funnel Plot for Rate Difference in Conductive Hearing Loss at 6-10 Years: Presence of Early Life OM versus Absence of Early Life OM ________________________________________________________________________________________________ 59fig3.doc Microsoft Word® Document MS Word® 2002 44KB 1 page Contents: Figure 3. Shrinkage Plot for Relative Risk of Conductive Hearing Loss at 6-10 Years: Positive Early Life OM versus Negative Early Life OM ________________________________________________________________________________________________ 60fig4.doc Microsoft Word® Document MS Word® 2002 36KB 1 page Contents: Figure 4. Funnel Plot for Log Relative Risk of Conductive Hearing Loss at 6-10 Years: Positive Early Life OM versus Negative Early Life OM ________________________________________________________________________________________________ 61fig5.doc Microsoft Word® Document MS Word® 2002 32KB 1 page Contents: Figure 5. Receiver Operator Characteristic (ROC) Plot for 8 Diagnostic Procedures versus Myringotomy ________________________________________________________________________________________________ 62fig6.doc Microsoft Word® Document MS Word® 2002 86KB 1 page Contents: Positive and Negative Predictive Values of Pneumatic Otoscopy by Prevalence of Otitis Media With Effusion Based on Pooled Estimate of Sensitivity at 93.8% and Specificity at 80.5% ________________________________________________________________________________________________ 63chap4.doc Microsoft Word® Document MS Word® 2002 60KB 8 pages Contents: Chapter 4. Conclusions: Natural History of OME, Effects of Early-life OM on Long-Term Speech and Language Development, Effects of Early-life OM on Long-Term Hearing, Diagnostic Methods for OME, Study Limitations, Question Selection, Study Language, Study Quality, Influencing Factors ________________________________________________________________________________________________ 64chap5.doc Microsoft Word® Document MS Word® 2002 36KB 4 pages Contents: Chapter 5. Future Research: General Issues, Natural History, Effects of Early-life OM on Long-Term Speech and Language Development, Effects of Early-life OM on Long-Term Hearing, Diagnostic Methods for OME ________________________________________________________________________________________________ 65refs.doc Microsoft Word® Document MS Word® 2002 102KB 11 pages Contents: References ________________________________________________________________________________________________ 66etbl1.doc Microsoft Word® Document MS Word® 2002 247KB 38 pages Contents: Evidence Table 1. Natural History of Otitis Media With Effusion ________________________________________________________________________________________________ 67etbl2.doc Microsoft Word® Document MS Word® 2002 160KB 18 pages Contents: Evidence Table 2. Early Life OM and Long-Term Speech and Language Development ________________________________________________________________________________________________ 68etbl3.doc Microsoft Word® Document MS Word® 2002 79KB 8 pages Contents: Evidence Table 3. Early Life OM and Long-Term Hearing ________________________________________________________________________________________________ 69etbl4.doc Microsoft Word® Document MS Word® 2002 523KB 99 pages Contents: Evidence Table 4. Diagnostic Methods ________________________________________________________________________________________________ 70front2.doc Microsoft Word® Document MS Word® 2002 60KB 4 pages Contents: Volume 2. Bibliography and Appendixes: Title Page, Table of Contents ________________________________________________________________________________________________ 71biblio.doc Microsoft Word® Document MS Word® 2002 1.4MB 203 pages Contents: Bibliography ________________________________________________________________________________________________ 72appa.doc Microsoft Word® Document MS Word® 2002 56KB 8 pages Contents: Appendix A. The 20 Suggested Questions on Diagnosis and Treatment of Otitis Media with Effusion ________________________________________________________________________________________________ 73appb.doc Microsoft Word® Document MS Word® 2002 97KB 7 pages Contents: Appendix B. Scope for Key Questions and Voting Options for Technical Experts ________________________________________________________________________________________________ 74appc.doc Microsoft Word® Document MS Word® 2002 176KB 6 pages Contents: Appendix C. Technical Expert Panel Comments on Scope ________________________________________________________________________________________________ 75appd.doc Microsoft Word® Document MS Word® 2002 96KB 6 pages Contents: Appendix D. Final Version of Scope ________________________________________________________________________________________________ 76appe.doc Microsoft Word® Document MS Word® 2002 98KB 4 pages Contents: Appendix E. Questionnaire for Polling Experts' Opinion on Influence of Non-Condition Factors on Outcomes ________________________________________________________________________________________________ 77appf.doc Microsoft Word® Document MS Word® 2002 327KB 7 pages Contents: Appendix F. Experts' Opinion on Influence of Non-Condition Factors on Outcomes ________________________________________________________________________________________________ 78appg.doc Microsoft Word® Document MS Word® 2002 49KB 5 pages Contents: Appendix G. Literature Search Strategy ________________________________________________________________________________________________ 79apph.doc Microsoft Word® Document MS Word® 2002 38KB 5 pages Contents: Appendix H. OME Screening Form Instructions ________________________________________________________________________________________________ 80appi.doc Microsoft Word® Document MS Word® 2002 418KB 64 pages Contents: Appendix I. Peer Review Comments and Responses ________________________________________________________________________________________________
AHRQ Publication No. 03-E023
Current as of May 2003
Internet Citation:
Diagnosis, Natural History, and Late Effects of Otitis Media With Effusion. File Inventory, Evidence Report/Technology Assessment Number 55. AHRQ Publication No. 03-E023, May 2003. Agency for Healthcare Research and Quality, Rockville, MD. http://www.ahrq.gov/clinic/omeffinv.htm
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