Evidence Report/Technology Assessment Number 57

Diagnosis and Treatment of Parkinson's Disease: A Systematic Review of the Literature

File Inventory


Prepared by:

MetaWorks, Inc., Evidence-based Practice Center
Medford, MA

Investigators
   Cindy B. Levine, M.D.
   Kyle R. Fahrbach, Ph.D.
   Andrew D. Siderowf, M.D.
   Rhonda P. Estok, R.N., B.S.N.
   Veronica M. Ludensky, B.A.
   Susan D. Ross, M.D., FRCPC


File Name	Description				Software	Version	File	Size
________________________________________________________________________________________________

01front.doc	Microsoft Word® Document		MS Word®	2002	90KB	10 pages
Contents: Title Page, Preface, Structured Abstract, Table of Contents

02summ.doc	Microsoft Word® Document		MS Word®	2002	53KB	7 pages
Contents: Summary: Overview, Reporting the Evidence, Methodology, Findings, Future Research

03chap1.doc	Microsoft Word® Document		MS Word®	2002	81KB	13 pages
Contents: Chapter 1. Introduction: Etiology, Clinical Features, Diagnosis, Assessment of PD Severity, 
Treatment, Objectives, Original Key Questions, Revised Key Questions

04chap2.doc	Microsoft Word® Document		MS Word®	2002	75KB	11 pages
Contents: Chapter 2. Methodology: Literature Search, Exclusion Criteria, Inclusion Criteria, 
Linked Studies, Rating the Evidence, Data Extraction, Database Development, Statistical Methods, 
Role of Consultants, Peer Review

05fig1.ppt	Microsoft PowerPoint® Presentation	MS PowerPoint®	2002	89KB	1 page
Contents: Figure 1. MetaWorks Systematic Review Process Diagram

06chap3.doc	Microsoft Word® Document		MS Word®	2002	203KB	30 pages
Contents: Chapter 3. Results: Searches, Studies, Diagnosis, Pharmacological Treatment of PD, 
Surgical Treatment of PD, Psychiatric Treatment, Ancillary Treatment, Genetics

07fig2.ppt	Microsoft PowerPoint® Presentation	MS PowerPoint®	2002	35KB	1 page
Contents: Figure 2. Study Attrition

08fg3-11.doc	Microsoft Word® Document		MS Word®	2002	278KB	9 pages
Contents: Figure 3. Dopamine Agonist + L-Dopa vs. L-Dopa,
Figure 4. Selegiline + L-Dopa vs. L-Dopa,
Figure 5. COMT Inhibitor + L-Dopa vs. L-Dopa,
Figure 6. Surgery: Pallidotomy (Off Scores),
Figure 7. Surgery: Pallidotomy (On Scores),
Figure 8. Surgery: Deep Brain Stimulation (Off Scores),
Figure 9. Surgery: Deep Brain Stimulation (On Scores),
Figure 10. Surgery: Fetal Cell Transplant (Off Scores),
Figure 11. Surgery: Fetal Cell Transplant (On Scores)

09chap4.doc	Microsoft Word® Document		MS Word®	2002	38KB	4 pages
Contents: Chapter 4. Answers to Revised Key Questions

10chap5.doc	Microsoft Word® Document		MS Word®	2002	24KB	1 page
Contents: Chapter 5. Strengths and Limitations of the Evidence Base

11chap6.doc	Microsoft Word® Document		MS Word®	2002	30KB	3 pages
Contents: Chapter 6. Recommendations for Future Research

12chap7.doc	Microsoft Word® Document		MS Word®	2002	20KB	1 page
Contents: Chapter 7. Harnessing the Available Evidence

13refs.doc	Microsoft Word® Document		MS Word®	2002	152KB	16 pages
Contents: References

14evtbls.xls	Microsoft Excel® Worksheet		MS Excel®	2002	90KB	16 pages
Contents: Evidence Tables: Evidence Table 1.  Summary of Rejected Studies,
Evidence Table 2. Study Level Characteristics,
Evidence Table 3. Overall Treatment Level Characteristics,
Evidence Table 4. Treatment Level Characteristics  of Diagnostic Studies,
Evidence Table 5. Treatment Level Characteristics of Pharmacological Studies,
Evidence Table 6. Statistical Analysis: Dopamine Agonists with L-Dopa vs. L-Dopa Alone,
Evidence Table 7. Statistical Analysis: Selegiline with L-Dopa vs. L-Dopa Alone,
Evidence Table 8. Statistical Analysis: COMT Inhibitors with L-Dopa vs. L-Dopa Alone,
Evidence Table 9. Pharmacological Studies: Adverse Events,
Evidence Table 10. Pharmacological Studies: Neurological and Psychiatric Adverse Events,
Evidence Table 11. Treatment Level Characteristics of Surgical Studies,
Evidence Table 12. Statistical Analysis: Pallidotomy,
Evidence Table 13. Statistical Analysis: Deep Brain Stimulation,
Evidence Table 14. Statistical Analysis: Tissue Transplantation,
Evidence Table 15. Surgical Studies: Adverse Events,
Evidence Table 16. Treatment Level Characteristics of Ancillary Studies

15biblio.doc	Microsoft Word® Document		MS Word®	2002	167KB	16 pages
Contents: Bibliography

16appa.doc	Microsoft Word® Document		MS Word®	2002	212KB	41 pages
Contents: Appendix A. Major Parkinson's Disease Rating Scales

17appb.doc	Microsoft Word® Document		MS Word®	2002	159KB	23 pages
Contents: Appendix B. Work Plan

18appc.doc	Microsoft Word® Document		MS Word®	2002	55KB	2 pages
Contents: Appendix C. Topic Assessment and Refinement

19appd-1.doc	Microsoft Word® Document		MS Word®	2002	20KB	1 page
Contents: Appendix D. Causal Pathways: Diagnosis and Treatment of Parkinson's Disease:
Cover page

20appd-2.doc	Microsoft Word® Document		MS Word®	2002	25KB	2 pages
Contents: Appendix D. Causal Pathways: Diagnosis and Treatment of Parkinson's Disease:
Causal Pathway: Diagnosis of Parkinson's Disease Legends

21appd-3.ppt	Microsoft PowerPoint® Presentation	MS PowerPoint®	2002	35KB	1 page
Contents: Appendix D. Causal Pathways: Diagnosis and Treatment of Parkinson's Disease:
Causal Pathway: Diagnosis of Parkinson's Disease

22appd-4.doc	Microsoft Word® Document		MS Word®	2002	24KB	1 page
Contents: Appendix D. Causal Pathways: Diagnosis and Treatment of Parkinson's Disease:
Causal Pathway: Treatment of Parkinson's Disease Legends

23appd-5.ppt	Microsoft PowerPoint® Presentation	MS PowerPoint®	2002	27KB	1 page
Contents: Appendix D. Causal Pathways: Diagnosis and Treatment of Parkinson's Disease:
Causal Pathway: Treatment of Parkinson's Disease

24appe-1.doc	Microsoft Word® Document		MS Word®	2002	20KB	1 page
Contents: Appendix E. Screening Sheets and Data Extraction Forms

25appe-2.xls	Microsoft Excel® Worksheet		MS Excel®	2002	34KB	3 pages
Contents: Appendix E. Screening Sheets and Data Extraction Forms (continued)

26appe-3.doc	Microsoft Word® Document		MS Word®	2002	26KB	1 page
Contents: Appendix E. Screening Sheets and Data Extraction Forms (continued)

27appe-4.doc	Microsoft Word® Document		MS Word®	2002	27KB	1 page
Contents: Appendix E. Screening Sheets and Data Extraction Forms (continued)

28appe-5.doc	Microsoft Word® Document		MS Word®	2002	28KB	1 page
Contents: Appendix E. Screening Sheets and Data Extraction Forms (continued)

29appe-6.xls	Microsoft Excel® Worksheet		MS Excel®	2002	51KB	4 pages
Contents: Appendix E. Screening Sheets and Data Extraction Forms (continued)

30appe-7.xls	Microsoft Excel® Worksheet		MS Excel®	2002	57KB	5 pages
Contents: Appendix E. Screening Sheets and Data Extraction Forms (continued)

31appe-8.xls	Microsoft Excel® Worksheet		MS Excel®	2002	54KB	5 pages
Contents: Appendix E. Screening Sheets and Data Extraction Forms (continued)

32appe-9.xls	Microsoft Excel® Worksheet		MS Excel®	2002	41KB	4 pages
Contents: Appendix E. Screening Sheets and Data Extraction Forms (continued)

33appf.doc	Microsoft Word® Document		MS Word®	2002	63KB	3 pages
Contents: Appendix F. Statistical Reference

34appg-1.doc	Microsoft Word® Document		MS Word®	2002	20KB	1 page
Contents: Appendix G. Technical Experts and Peer Reviewers

35appg-2.xls	Microsoft Excel® Worksheet		MS Excel®	2002	20KB	2 pages
Contents: Appendix G. Technical Experts and Peer Reviewers (continued)

36appg-3.xls	Microsoft Excel® Worksheet		MS Excel®	2002	15KB	1 page
Contents: Appendix G. Technical Experts and Peer Reviewers (continued)

37appg-4.doc	Microsoft Word® Document		MS Word®	2002	48KB	2 pages
Contents: Appendix G. Technical Experts and Peer Reviewers (continued)

38apph.doc	Microsoft Word® Document		MS Word®	2002	158KB	17 pages
Contents: Appendix H. Accepted Studies Log

39appi.doc	Microsoft Word® Document		MS Word®	2002	263KB	29 pages
Contents: Appendix I. Rejected Studies Log

40appj.doc	Microsoft Word® Document		MS Word®	2002	44KB	6 pages
Contents: Appendix J. Studies of Interest Excluded from Database

41appk.doc	Microsoft Word® Document		MS Word®	2002	35KB	4 pages
Contents: Appendix K. Acronyms in This Report
________________________________________________________________________________________________

AHRQ Publication No. 03-E040
Current as of June 2003


Internet Citation:

Diagnosis and Treatment of Parkinson's Disease: A Systematic Review of the Literature. File Inventory, Evidence Report/Technology Assessment Number 57. AHRQ Publication No. 03-E040, June 2003. Agency for Healthcare Research and Quality, Rockville, MD. http://www.ahrq.gov/clinic/parkinv.htm


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