Evidence Report/Technology Assessment Number 45

Management of Chronic Central Neuropathic Pain Following Traumatic Spinal Cord Injury

File Inventory


Prepared by:

McMaster University Evidence-based Practice Center
Alex Jadad, M.D.
   Principal Investigator
Mary Ann O'Brien, MSc
Dean Wingerchuk, M.D.
Pam Angle, M.D.
Heather Biagi, BHSc
Matt Denkers, BHSc
Carmen Tamayo, M.D.
Mary Gauld, BA
   Investigators


File Name	Description			Software	Version		File	Size
__________________________________________________________________________________________________________
01front.doc	Microsoft Word® Document	MS Word®	2002		48KB	7 pages
Contents: Cover Page, Title Page, Preface, Structured Abstract

02conts.doc	Microsoft Word® Document	MS Word®	2002		30KB	3 pages
Contents: Table of Contents

03summ.doc	Microsoft Word® Document	MS Word®	2002		60KB	8 pages
Contents: Summary: Introduction, Methodology, Future Research

04chap1.doc	Microsoft Word® Document	MS Word®	2002		96KB	6 pages
Contents: Chapter 1. Pain as a Problem Following Traumatic Spinal Cord Injury:
Introduction; Classification of Pain after SCI; The Role of Systematic Reviews 
in the Study of Neuropathic Pain after Traumatic Spinal Cord Injury; 
Commissioning of This Report; Review Questions; Anticipated Challenges for This Task Order; 
The Collaborative Team

05chap2.doc	Microsoft Word® Document	MS Word®	2002		48KB	6 pages
Contents: Chapter 2. Methodology: Introduction; Technical Expert Panel; Consultations With 
the Task Order Officer and Partners; Peer Reviewers; Topic Assessment and Refinement; 
Screening Process; Data Extraction Process; Data Synthesis

06chap3.doc	Microsoft Word® Document	MS Word®	2002		34KB	3 pages
Contents: Chapter 3. General Results: Results of the Literature Search; Results of 
the Screening Process; General Characteristics of All Included Studies

07chap4.doc	Microsoft Word® Document	MS Word®	2002		141KB	9 pages
Contents: Chapter 4. Diagnosis, Assessment and Natural History of Pain After Traumatic 
Spinal Cord Injury: Background; Methods; Results; Discussion

08chap5.doc	Microsoft Word® Document	MS Word®	2002		104KB	6 pages
Contents: Chapter 5. Pharmacological Interventions: Background; Results; 
Implications for Practice

09chap6.doc	Microsoft Word® Document	MS Word®	2002		135KB	7 pages
Contents: Chapter 6. Spinal Cord and Deep Brain Stimulation Techniques: Introduction; 
Types of Stimulation; Methods; Results; Discussion

10chap7.doc	Microsoft Word® Document	MS Word®	2002		118KB	6 pages
Contents: Chapter 7. Dorsal Root Entry Zone Lesions and Other Surgical Interventions:
Introduction; Methods; Results; Discussion

11chap8.doc	Microsoft Word® Document	MS Word®	2002		32KB	3 pages
Contents: Chapter 8. Conclusions and Implications for Future Research: General Implications 
for Research; Limitations of This Task Order Report; Closing Remarks

12refs.doc	Microsoft Word® Document	MS Word®	2002		101KB	9 pages
Contents: References

13et3-1.doc	Microsoft Word® Document	MS Word®	2002		35KB	1 page
Contents: Evidence Table 3.1: Electronic Database Search Yield

14et3-1a.doc	Microsoft Word® Document	MS Word®	2002		26KB	1 page
Contents: Evidence Table 3.1a: Sensitivity and Specificity of Electronic Database Searches

15et3-2.doc	Microsoft Word® Document	MS Word®	2002		34KB	2 pages
Contents: Evidence Table 3.2: Results of Screening Process

16et3-3.doc	Microsoft Word® Document	MS Word®	2002		42KB	1 page
Contents: Evidence Table 3.3: Screening of Articles in Languages Other Than English 
Requiring Translation

17et3-4.doc	Microsoft Word® Document	MS Word®	2002		54KB	3 pages
Contents: Evidence Table 3.4: Studies with Multiple Citations

18et3-5.doc	Microsoft Word® Document	MS Word®	2002		48KB	2 pages
Contents: Evidence Table 3.5: Citations of Studies Excluded During Data Extraction

19et3-6.doc	Microsoft Word® Document	MS Word®	2002		266KB	11 pages
Contents: Evidence Table 3.6.1: Year of Publication; Evidence Table 3.6.2: Source of Funding; 
Evidence Table 3.6.3: Country of Publication; Evidence Table 3.6.4: Study Design; 
Evidence Table 3.6.5: Direction of Investigation; Evidence Table 3.6.6: Patients in Study Sample; 
Evidence Table 3.6.7: Patients in Study Sample With TSCI/CNP; 
Evidence Table 3.6.8: Health Care Setting; Evidence Table 3.6.9: Eligibility Criteria Reported; 
Evidence Table 3.6.10: Study Duration Preplanned; Evidence Table 3.6.11: Preplanned Study 
Duration for One Patient; Evidence Table 3.6.12: Number of Groups; 
Evidence Table 3.6.13: Interventions; Evidence Table 3.6.14: Level of Injury; 
Evidence Table 3.6.15: Completeness of Injury; Evidence Table 3.6.16: Classification; 
Evidence Table 3.6.17: Cause of Injury; Evidence Table 3.6.18: Surgical Stabilization; 
Evidence Table 3.6.19: Time Since Injury; Evidence Table 3.6.20: Age; 
Evidence Table 3.6.21: Gender; Evidence Table 3.6.22: Neuropathic Pain Defined by Authors; 
Evidence Table 3.6.23: Cause of Injury; Evidence Table 3.6.24: Start of Pain After Injury; 
Evidence Table 3.6.25: Duration of Pain; Evidence Table 3.6.26: Area of Body Affected by Pain; 
Evidence Table 3.6.27: Temporal Properties of Pain; Evidence Table 3.6.28: Siddall Classification of Pain; 
Evidence Table 3.6.29: Outcome Measures; Evidence Table 3.1.30: Relaxation Techniques; 
Evidence Table 3.1.31: Laughing

20et4-1.doc	Microsoft Word® Document	MS Word®	2002		66KB	7 pages
Contents: Evidence Table 4.1: Characteristics of Studies Assessing Central Neuropathic Pain; 
Supplemental Evidence Table 4.1: Other Studies Addressing the Prevalence of and Factors 
Associated with Neuropathic Pain: Shoulder Hand Syndrome (SHS)

21et4-2.doc	Microsoft Word® Document	MS Word®	2002		35KB	2 pages
Contents: Evidence Table 4.2: Characteristics of Studies Evaluating Outcome Tools 
for Central Neuropathic Pain

22et4-3.doc	Microsoft Word® Document	MS Word®	2002		215KB	24 pages
Contents: Evidence Table 4.3:  Characteristics of Studies Addressing the Prevalence of 
and Factors Associated With CNP

23et4-3s.doc	Microsoft Word® Document	MS Word®	2002		116KB	11 pages
Contents: Supplemental Evidence Table 4.3: Other Studies Addressing the Prevalence of 
and Factors Associated with Neuropathic Pain: Shoulder Hand Syndrome (SHS);
Supplemental Evidence Table 4.3: Other Studies Addressing the Prevalence of 
and Factors Associated with Neuropathic Pain: Post-traumatic Syringomeylia; 
Supplemental Evidence Table 4.3: Other Studies Addressing the Prevalence of 
and Factors Associated with Neuropathic Pain: Reflex Sympathetic Dystrophy Syndrome (RSDS);
Supplemental Evidence Table 4.3: Other Studies Addressing the Prevalence of 
and Factors Associated with Neuropathic Pain: Hyperpathia;
Supplemental Evidence Table 4.3: Other Studies Addressing the Prevalence of 
and Factors Associated with Neuropathic Pain: Phantom Pain;
Supplemental Evidence Table 4.3: Other Studies Addressing the Prevalence of 
and Factors Associated with Neuropathic Pain: Chronic Cyclical Pain

24et4-4.doc	Microsoft Word® Document	MS Word®	2002		38KB	2 pages
Contents: Evidence Table 4.4: Estimates of Prevalence of CNP in a Community Sample

25et4-5.doc	Microsoft Word® Document	MS Word®	2002		63KB	3 pages
Contents: Evidence Table 4.5: Studies Generating or Testing Hypotheses 
About Chronic Neuropathic Pain in SCI

26et5-1.doc	Microsoft Word® Document	MS Word®	2002		121KB	12 pages
Contents: Studies of Pharmacological Interventions:
Evidence Table 5.1.1: Opioids (Alfentanil), Ketamine; Evidence Table 5.1.2: Opioids (Morphine), 
Buprenorphine, Clonidine; Evidence Table 5.1.3: Opioids (Morphine), Amitriptyline, Clonazepam, 
Others; Evidence Table 5.1.4: Anticonvulsants (Valproate); Evidence Table 5.1.5: Anticonvulsants 
(Gabapentine); Evidence Table 5.1.6: Local Anesthetics and Drugs With Anesthetic Properties 
(Mexiletine); Evidence Table 5.1.7: Local Anesthetics and Drugs With Anesthetic Properties 
(Lidocaine); Evidence Table 5.1.8: Adrenergics and Cholinergic Agonists (Clonidine);
Evidence Table 5.1.9: Baclofen; Evidence Table 5.1.10: Trazodone Hydrocloride;
Evidence Table 5.1.11: Combination-Pharmacological (Amitriptyline + Carbamazepine) and 
Nonpharmacological Treatment (Electroacupuncture); Evidence Table 5.1.12: Combination-
Pharmacological (Melitracen + Flupenthixol) and Nonpharmacological Treatment (TENS)

27et5-1s.doc	Microsoft Word® Document	MS Word®	2002		142KB	15 pages
Contents: Studies of Pharmacological Interventions:
Supplemental Evidence Table 5.1.1: Opioids (Morphine) and Clonidine; 
Supplemental Evidence Table 5.1.2: Aminopyridine; Supplemental Evidence Table 5.1.3: Baclofen;
Supplemental Evidence Table 5.1.4: Baclofen; Supplemental Evidence Table 5.1.5: Carbamazepine;
Supplemental Evidence Table 5.1.6: Local Anesthetics (Lidocaine); Supplemental Evidence Table 
5.1.7: Local Anesthetic (Midazolam); Supplemental Evidence Table 5.1.8: Amitriptyline, Carbamazepine;
Supplemental Evidence Table 5.1.9: Amitriptyline Plus Other Nonpharmacologics;
Supplemental Evidence Table 5.1.10: Amitriptyline Plus Other Nonpharmacologics;
Supplemental Evidence Table 5.1.11: Carbamazepine, Clonipramine; Supplemental Evidence Table 5.1.12: 
Combination (Buprenorphine, Diazepam, Thiamylal); Supplemental Evidence Table 5.1.13: Combination 
(Gabapentin and Clonazepam); Supplemental Evidence Table 5.1.14: Combination (Gabapentin, Tramadol, 
Flunitrazepam); Supplemental Evidence Table 5.1.15: Other (Aspirin in Chloroform)

28et5-2.doc	Microsoft Word® Document	MS Word®	2002		46KB	2 pages
Contents: Evidence Table 5.2: Pharmacologic Studies Sorted by Study Design

29et6-1.doc	Microsoft Word® Document	MS Word®	2002		58KB	5 pages
Contents: Evidence Table 6.1: Characteristics of Studies Using Spinal Cord Stimulation

30et6-1s.doc	Microsoft Word® Document	MS Word®	2002		124KB	12 pages
Contents: Supplemental Evidence Table 6.1: Characteristics of Case Studies 
Using Spinal Cord Stimulation

31et6-2.doc	Microsoft Word® Document	MS Word®	2002		91KB	6 pages
Contents: Evidence Table 6.2: Characteristics of Studies Using Brain Stimulation;
Supplemental Evidence Table 6.2: Characteristics of Case Studies Using Brain Stimulation

32et6-3.doc	Microsoft Word® Document	MS Word®	2002		37KB	2 pages
Contents: Evidence Table 6.3: Characteristics of Studies Using Transcutaneous Electrical 
Nerve Stimulation (TNS) for Treatment of Pain

33et7-1.doc	Microsoft Word® Document	MS Word®	2002		75KB	9 pages
Contents: Evidence Table 7.1: Characteristics of Studies for Dorsal Root Entry Zone (DREZ) 
Interventions

34et7-1s.doc	Microsoft Word® Document	MS Word®	2002		75KB	5 pages
Contents: Supplemental Evidence Table 7.1: Characteristics of Studies for Dorsal Root Entry Zone 
(DREZ) Interventions

35et7-2.doc	Microsoft Word® Document	MS Word®	2002		81KB	10 pages
Contents: Evidence Table 7.2: Characteristics of Studies Evaluating Other Spinal Surgical 
Procedures; Supplemental Evidence Table 7.2: Case Reports of Other Spinal Surgical Technologies

36biblio.doc	Microsoft Word® Document	MS Word®	2002		243KB	28 pages
Contents: Bibliography

37appa.doc	Microsoft Word® Document	MS Word®	2002		22KB	1 page
Contents: Appendix A. Consortium for Spinal Cord Medicine Member Organizations

38appb.doc	Microsoft Word® Document	MS Word®	2002		47KB	5 pages
Contents: Appendix B. Personnel

39appc.doc	Microsoft Word® Document	MS Word®	2002		28KB	2 pages
Contents: Appendix C. Peer Reviewers for the Management of Chronic Central Neuropathic Pain 
Following Traumatic Spinal Cord Injury

40appd.doc	Microsoft Word® Document	MS Word®	2002		23KB	1 page
Contents: Appendix D. Final Search Strategy for Primary Studies

41appe.doc	Microsoft Word® Document	MS Word®	2002		44KB	5 pages
Contents: Appendix E. Assessment and Natural History Study Form

42appf.doc	Microsoft Word® Document	MS Word®	2002		27KB	2 pages
Contents: Appendix F. Acronyms and Abbreviations
__________________________________________________________________________________________________________

AHRQ Publication No. 01-E063
Current as of September 2001


Internet Citation:

Management of Chronic Central Neuropathic Pain Following Traumatic Spinal Cord Injury. File Inventory, Evidence Report/Technology Assessment Number 45. AHRQ Publication No. 01-E063, September 2001. Agency for Healthcare Research and Quality, Rockville, MD. http://www.ahrq.gov/clinic/scinjinv.htm


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