HomeResearchIntramural ResearchResearch Branches at NHGRIInherited Disease Research Branch Wilson Lab

Alexander F. Wilson, Ph.D. Senior Investigator Inherited Disease Research Branch Head Genometrics Section B.A. Western Maryland College, 1975 Ph.D. Indiana University, 1980 (410) 550-7510 (410) 550-7513 afw@nhgri.nih.gov Johns Hopkins University 333 Cassell Drive, Suite 2000 Baltimore, MD 21224 Selected Publications Genometric Analysis Simulation Program (GASP)

Our research focuses on identifying genetic effects that may be responsible for phenotypic variation in quantitative traits, and developing statistical genetic methods that can be used to determine these effects. We are currently involved in a number of projects: the genetic analysis of complex quantitative phenotypes such as scoliosis, hypertension, cardiovascular disease and obesity; the development of statistical methods that address problems associated with the detection of multiple trait loci, multiple tests and new marker technologies; an investigation of the statistical properties of new methods of genetic analysis using computer simulation; and the development of the Genometric Analysis Simulation Program (G.A.S.P.). Our laboratory is located on the Johns Hopkins University Bayview Campus in Baltimore, MD.

Our past research efforts included studies of the statistical validity and power of extensions to the Haseman-Elston sib-pair test, the graphical presentation of results from genomic screening and alternative methods (moving averages and n-locus clustering) for multipoint linkage analysis. In addition, we developed a stepwise oligogenic segregation and linkage analysis that can be used to identify multiple genetic loci involved in the expression of a single trait.

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Last Updated: June 2004