Updated Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents

Source: FDA

The "Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents," was updated today (March 23, 2004), and is available at AIDSinfo.nih.gov. The guidelines were developed, and are updated by the panel on Clinical Practices for Treatment of HIV Infection, convened by the Department of Health and Human Services (HHS). The changes in this update are outlined below.

1. "Table 12a – Antiretroviral Regimens Recommended for Treatment of HIV-1 Infection in Antiretroviral Naïve Patients":
   
   Additions:
   • Fosamprenavir and ritonavir-boosted fosamprenavir to be added as part of Alternative PI-based regimens for initiation of therapy in treatment-naïve patients.
   • "Abacavir + lamivudine" has been added as an alternative 2-NRTI backbone.
   
   
   Deletions:
   • Ritonavir-boosted amprenavir has been removed as an alternative PI-based regimen for initiation of therapy in treatment naïve patients.
   • Indinavir (unboosted) has been removed as an alterative PI-based regimen for initiation of therapy in treatment-naïve patients.
   
   
2. New safety information regarding the risks of nevirapine-associated symptomatic hepatic events has been added to the text of the guidelines (sections on "NNRTI-Based Regimens" and "Hepatotoxicity") and the respective tables (Tables 12a, 12b, and 19).
   
   
3. Characteristics and drug interaction information for fosamprenavir have been added to the respective tables (Tables 17, 20, 21, 22a, 22b, 23, and 30).
   
   
4. A new table (Table 13) with "Antiretroviral Dosing Recommendations for Patients with Renal or Hepatic Dysfunction" has been created.

The complete, updated Adult and Adolescent Guidelines are available on AIDSinfo.nih.gov.

Other HIV-related guidelines available on the site are:

• Antiretroviral Treatment
  Pediatric Guidelines
  
  
• Maternal-Child Transmission
  Perinatal Guidelines
  
  
• Post-Exposure Prophylaxis
  Health-Care Worker Exposure Guidelines
  Nonoccupational Exposure Considerations
  
  
• Management of HIV Complications
  Tuberculosis Guidelines
  Opportunistic Infections Guidelines
  Incorporation of HIV Prevention
  
  
• Testing
  Revised Guidelines for Counseling, Testing, and Referral