The overall goal of the Laboratory of Molecular Hematology is to determine the mechanisms by which gene expression is regulated. Specific goals include: (1) transcriptional regulation of rate limiting translation initiation factors during T-cell activation, (2) the role of the transcription factor a-Pal in the coordination of cell growth, cell cycle activity and differentiation, (3) the functional consequences of a-Pal heterodimerization with Max and other b-Zip proteins, and (4) the development of adeno-associated virus (AAV).