The Center for Advanced Research in Biotechnology (CARB) is a joint venture of the University of Maryland, the National Institute of Standards and Technology (NIST), and Montgomery County that provides a unique enviorment for collaborative research among academic, government, and industry scientists.

The CARB faculty, consisting of scientists from the University of Maryland and NIST, conduct basic research programs at the frontiers of structural and physical biochemistry and molecular biology. Located on the new Shady Grove campus of the University of Maryland in Rockville, CARB lies in the heart of Maryland's growing biotechnology community and is near all the major University of Maryland research campuses as well at the National Institutes of Health and NIST. CARB's modern research facility contains well-equpped laboratories with state-of-the-art instrumentation in the areas of molecular biology, X-ray crystallography, NMR spectroscopy, CD, calorimetry, and computing science. CARB provides an exceptional enviornment for training graduate students and postdoctoral fellows in fields critical to the future of biotechnology.

Current faculty research interest include the following areas:

• Engineering protein folding and stability (P. Bryan)
• Assembly and control of activity of regulatory proteins using molecular biology and physical biochemistry (E. Eisenstein)
• Physical chemistry of the structure and function of biological macromolecules (M. Gilson)
• X-ray crystallography of biological macromolecules (G. Gilliland, O. Herzberg)
• Computational studies of protein folding and functions (J. Moult)
• Structural and dynamical studies of proteins and nucleic acids using NMR spectroscopy (J. Orban, J.P. Marino, J.B. Ames.)
• Computational studies of the evolution of genes, proteins, and genomes (A. Stoltzfus)
• Structural immunology, structure specificity of antibody-antigen complexes (R. Mariuzza)
• Static and dynamic properties of membrane protein structure (K. Ridge)
• Thermodynamics of protein-ligand interactions and protein stability in solution using microcalorimetry (F. Schwarz)
• Computational chemistry applied to enzyme mechanisms and molecular interactions (M. Krauss)
• Functional genomics of cellular differentiation (H. Smith)
• Mechanism of chromosomal DNA replication (Z. Kelman)

For further information see CARB Research Highlights.

SUPPORT:
Enrollment and support are available through the Molecular and Cell Biology program of the University of Maryland system and other joint programs with the University of Maryland System campuses.

APPLICATIONS AND INFORMATION:
Applications and information may be obtained from:
Dr. John Orban
CARB
9600 Gudelsky Drive
Rockville, MD 20850
Phone: (301) 738-6272

Please send comments to: webmaster-carb@nist.gov.