In 1999, scientists reported that a particular variant of the angiotens in-converting enzyme (ACE) gene was associated with superior physical endurance. The variant, known as the ACE insertion polymorphism, was found to be present in a higher proportion of elite endurance athletes, especially long distance runners, than in the general population.

Vignette:

Marathon University is offering full-tuition scholarships and a guaranteed spot on the varsity track team to high-school sophomores who "pass" a genetic test. If the parents sign a consent form, University doctors will screen them for the ACE insertion polymorphism.

Discussion points:

• Is it likely that a single gene determines physical endurance?
• Are other genes likely to be important?
• What other factors determine whether a child will grow up to be an elite endurance athlete?
• Should parents be allowed to use genetic information to make decisions that will limit their children’s choices in adulthood?
• What else should MU do if it is concerned about the well being of the future student-athlete?