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The Laboratory of Population Genetics (LPG) utilizes genetic analysis to
gain insight into human biologic processes. Until recently, genetic dissection
of phenotypes had been largely limited to investigations in experimental
organisms. The dawn of the post-genome era presents the opportunity to
extend these investigations to humans. It is the major goal of this laboratory
to exploit emerging resources and technology in order to understand the
genetic basis of the complex phenotypes related to human cancer. The program
focuses on both the development of the resources and methods necessary to
achieve these goals, as well as the application of the methods in
characterizing the molecular genetic epidemiology of disease. The
LPG is organized around three inter-related areas: Human Genetic
Mapping, Genetic Phenotype Dissection, and Experimental Organism Genetics.
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Directory, Administrative Information, Joint Project ...
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The Buetow lab develops and exploits genetic, genomic,
and bioinformatic approaches to understand complex cancer phenotypes.
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The Hunter lab characterizes genetic modifiers of
cancer, including those that modulate breast cancer
initiation, tumor growth and metastasis.
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The Jen lab studies the genetic basis and molecular biology of lung cancer.
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The Lee lab uses genomic and bioinformatic approaches to study cancer
genetics and epigenetics.
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The Struewing lab studies the molecular epidemiology of breast
and ovarian cancer, with an emphasis on genetic variation in DNA repair genes.
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