Juvenile Rheumatoid Arthritis (JRA) is a chronic inflammatory arthritis in children. It occurs in between 50-100 per 100,000 children in the United States. JRA is a general term for the most common types of arthritis in children. It is divided in to several categories:

1. Systemic JRA: This form, which occurs in about 10% of cases, involves joint pain and swelling as well as fevers and rash. It is similar to Adult Still's Disease. The cause of this form of JRA is unknown.
2. Polyarticular JRA: This form occurs in about 40% of cases and involves multiple joints that are painful and swollen. The cause of this form of JRA is unknown. Some children may have a positive Rheumatoid Factor and evolve into Rheumatoid Arthritis.
3. Pauciarticular JRA: This form occurs in about 50% of cases and involves only a few joints. Some of these children, in particular boys, will be HLA-B27 positive. Families with HLA-B27 are at increased risk for this arthritis.

• joint stiffness on arising in the morning
• limited range of motion
• slow rate of growth or uneven arm or leg growth
• hot, swollen, painful joints
• a child my stop using an affected limb
• back pain

Systemic JRA symptoms:

• Fever, usually high fevers every day
• Rash that comes and goes with the fever
• Swollen lymph nodes (glands)

JRA can also cause eye inflammation. These symptoms include:

• red eyes
• eye pain
• photophobia (increased pain when looking at a light)
• visual changes

The physical examination shows swollen, warm, and tender joints that hurt to move. The child may have a rash. Other signs include an enlarged liver, enlarged spleen, or swollen lymph nodes.

Blood tests may include:

• CBC
• ESR (sedimentation rate)
• ANA
• RA factor
• HLA antigens for HLA B27

The doctor may need to tap a joint. This means that they will put a small needle into a joint that is swollen. This can help to find the cause of the arthritis. By removing fluid, the joint may feel better, too. Sometimes, the doctor will inject steroids into the joint to help decrease the swelling.

Other tests:

• X-ray of a joint
• X-ray of the chest
• ECG
• Eye exam by an ophthomologist

• nonsteroidal antiinflammatory agents (NSAIDS)
• corticosteroids
• topical ophthalmic corticosteroids
• hydroxychloroquine
• immune suppressing agents, including methotrexate and new biologic medications like infliximab and etanercept.

Note: Talk to your health care provider before giving aspirin or NSAIDS to children!

Physical therapy and exercise programs may be recommended. Surgical procedures may be indicated, including joint replacement.

• total joint destruction of the major weight-bearing joints
• loss of vision or decreased vision
• chronic spondyloarthropathy (back stiffness)