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Hepatitis B Vaccine
Post-vaccination Testing for Immune Response

Hepatitis B surface antibody (anti-HBs) titer (test for immune response) is recommended after three doses of vaccine are given, only for persons in the following risk groups:

  • health care workers who have the risk of exposure to blood or body fluids in the workplace (to guide post-exposure prophylaxis *)

  • infants born to hepatitis B surface antigen (HBsAg)-positive mothers (to ensure ongoing protection)

  • immunocompromised persons, e.g., dialysis patients, AIDS patients (to ensure protection)

  • sex partners of HBsAg-positive persons (to assure adequate response to vaccination).

Note: Testing is not recommended after routine vaccination of infants, children, or adolescents.

* Read the Updated U.S. Public Health Service Guidelines for the Management of Occupational Exposures to HBV, HCV, and HIV and Recommendations for Post-exposure Prophylaxis, MMWR dated 6/29/01 vol. 50 (rr11)

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This page last reviewed October 1, 2004

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