Prepared by:
Southern California-RAND Evidenced-Based Practice Center
Santa Monica, CA
Investigators
Director
Paul G. Shekelle, M.D., Ph.D.
Senior Statistician/Co-Director
Sally C. Morton, Ph.D.
Project Manager/Policy Analyst
Margaret Maglione, M.P.P.
Statisticians
Marika Suttorp, M.S.
Wenli Tu, M.S.
Reviewers
Zhaoping Li, M.D., Ph.D.
Melinda Maggard, M.D.
Walter A. Mojica, M.D., M.P.H.
Lisa Shugarman, Ph.D.
Vanessa Solomon, M.A.
Programmer/Analyst
Lara Jungvig, B.A.
Medical Editor
Sydne J. Newberry, Ph.D.
Staff Assistants
Donna Mead, B.A.
Shannon Rhodes, M.F.A.
File Name | Description | Software and Version | Size |
---|---|---|---|
01front.doc | Title page, Preface, Structured Abstract, Table of Contents | Word® 2002 | 55KB, 8 pages |
02chap1.doc | Chapter 1. Introduction: Prescription Weight Loss Medications, Bariatric Surgical Procedures | Word® 2002 | 107KB, 6 pages |
03chap2.doc | Chapter 2. Methods: Original Proposed Key Questions; Technical Expert Panel; Literature Search; Article Review; Meta-Analyses of Weight Loss Medications; Medication Adverse-Events Meta-Analysis; Surgery Analyses | Word® 2002 | 142KB, 12 pages |
04chap3.doc | Chapter 3. Results: Results of the Literature Search; Efficacy of Medications; Efficacy of Surgery for Weight Loss; Use of Obesity Medication and Bariatric Surgery in the Adolescent and Pediatric Population | Word® 2002 | 273KB, 18 pages |
05chap4.doc | Chapter 4. Discussion: Limitations, Conclusions, Future Research | Word® 2002 | 39KB, 5 pages |
06refs.doc | Reference List | Word® 2002 | 166KB, 14 pages |
07tbl1.doc | Table 1. Adverse events in medication studies | Word® 2002 | 202KB, 2 pages |
08tbl2.doc | Table 2. Adverse events in surgery studies | Word® 2002 | 115KB, 5 pages |
09tbl3.doc | Table 3. Surgical procedure categories | Word® 2002 | 38KB, 1 page |
10tbl4&5.doc | Table 4. Meta-analysis of weight loss in placebo-controlled trials of orlistat at 6 months; Table 5. Meta-analysis of weight loss in placebo-controlled trials of Orlistat at 12 months | Word® 2002 | 126KB, 1 page |
11tbl6.doc | Table 6. Meta-analysis of adverse events in RCTs of orlistat | Word® 2002 | 113KB, 1 page |
12tbl7&8.doc | Table 7. Meta-analysis of weight loss in placebo-controlled trials of fluoxetine at 6 months; Table 8. Meta-analysis of weight loss in placebo-controlled trials of fluoxetine at 12 months | Word® 2002 | 46KB, 1 page |
13tbl9.doc | Table 9. Meta-analysis of adverse events in RCTs of fluoxetine for obesity | Word® 2002 | 118KB, 1 page |
14t10&11.doc | Table 10. Meta-analysis of weight loss in placebo controlled trials of bupropion at 6-12 months; Table 11. Meta-analysis of adverse events in RCTs of bupropion | Word® 2002 | 113KB, 1 page |
15t12&13.doc | Table 12. Meta-analysis of weight loss in placebo controlled trials of topiramate at 6 months; Table 13. Meta-analysis of adverse events in RCTs of topiramate | Word® 2002 | 128KB, 1 page |
16tbl14.doc | Table 14. Summary of findings regarding medications for weight loss | Word® 2002 | 32KB, 1 page |
17tbl15.doc | Table 15. Summary of results of Cochrane review of surgery for morbid obesity | Word® 2002 | 29KB, 1 page |
18tbl16.doc | Table 16. Weight loss following bariatric surgery by procedure (at 12 months followup), pooled results by study type | Word® 2002 | 44KB, 1 page |
19tbl17.doc | Table 17. Weight loss following bariatric surgery by procedure (at ? 36 months followup), pooled results by study type | Word® 2002 | 43KB, 1 page |
20tbl18.doc | Table 18. Mortality analysis, surgical procedures | Word® 2002 | 29KB, 1 page |
21tbl19.doc | Table 19. Postoperative adverse events by bariatric procedure (RYGB versus VBG, Band, or BPD), results pooled by study type | Word® 2002 | 174KB, 5 pages |
22tbl20.doc | Table 20. Postoperative adverse events following bariatric procedures differs by operative approach (open versus laparoscopic), pooled results by study type | Word® 2002 | 108KB, 3 pages |
23fig1.doc | Figure 1a. Literature flow; Figure 1b. Literature flow, continued | Word® 2002 | 87KB, 2 pages |
24fig2.doc | Figure 2. Pooled analysis: 8- to 12-week trials of sibutramine, 10-15 mg daily | Word® 2002 | 46KB, 1 page |
25fig3.doc | Figure 3. Pooled analysis: 16- to 24-week trials of sibutramine, 10-15 mg daily | Word® 2002 | 62KB, 1 page |
26fig4.doc | Figure 4. Pooled analysis: 44- to 54-week trials of sibutramine, 10-15 mg daily | Word® 2002 | 44KB, 1 page |
27fig5.doc | Figure 5. Pooled analysis: orlistat, 6 months | Word® 2002 | 48KB, 1 page |
28fig6.doc | Figure 6. Pooled analysis: orlistat, 12 months | Word® 2002 | 58KB, 1 page |
29fig7&8.doc | Figure 7. Pooled analysis: fluoxetine, 6 months; Figure 8. Pooled analysis: fluoxetine, 12 months | Word® 2002 | 77KB, 1 page |
30fig9.doc | Figure 9. Pooled analysis: bupropion, 6-12 months | Word® 2002 | 42KB, 1 page |
31fig10.doc | Figure 10. Pooled analysis: topiramate | Word® 2002 | 44KB, 1 page |
32appa.doc | Appendix A. Preliminary Search Methodologies—Obesity; Obesity Updates to Aberdeen Searches Methodologies | Word® 2002 | 54KB, 9 pages |
33appb.doc | Appendix B: Figure 1. Screening form for literature; Figure 2. QRF | Word® 2002 | 142KB, 7 pages |
34apcet1.doc | Appendix C: Evidence Table-Medication | Word® 2002 | 547KB, 24 pages |
35apcet2.doc | Appendix C: Evidence Table-Surgery | Word® 2002 | 729KB, 40 pages |
36appd.doc | Appendix D: Table 1. Technical Expert Panel members; Table 2. Peer Reviewers | Word® 2002 | 39KB, 1 page |
37appe.doc | Appendix E: Obesity Peer and TEP Review | Word® 2002 | 243KB, 35 pages |
38appf.doc | Appendix F: Included Studies | Word® 2002 | 153KB, 13 pages |
39appg.doc | Appendix G: Excluded Studies | Word® 2002 | 348KB, 44 pages |
AHRQ Publication No. 04-E028-2
Current as of July 2004
Internet Citation:
Pharmacological and Surgical Treatment of Obesity. File Inventory, Evidence Report/Technology Assessment Number 103. AHRQ Publication No. 04-E028-2, July 2004. Agency for Healthcare Research and Quality, Rockville, MD. http://www.ahrq.gov/clinic/obesphinv.htm
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