Prepared by:
McMaster University Evidence-based Practice Center
Alex Jadad, M.D.
Principal Investigator
Mary Ann O'Brien, MSc
Dean Wingerchuk, M.D.
Pam Angle, M.D.
Heather Biagi, BHSc
Matt Denkers, BHSc
Carmen Tamayo, M.D.
Mary Gauld, BA
Investigators
File Name Description Software Version File Size __________________________________________________________________________________________________________ 01front.doc Microsoft Word® Document MS Word® 2002 48KB 7 pages Contents: Cover Page, Title Page, Preface, Structured Abstract 02conts.doc Microsoft Word® Document MS Word® 2002 30KB 3 pages Contents: Table of Contents 03summ.doc Microsoft Word® Document MS Word® 2002 60KB 8 pages Contents: Summary: Introduction, Methodology, Future Research 04chap1.doc Microsoft Word® Document MS Word® 2002 96KB 6 pages Contents: Chapter 1. Pain as a Problem Following Traumatic Spinal Cord Injury: Introduction; Classification of Pain after SCI; The Role of Systematic Reviews in the Study of Neuropathic Pain after Traumatic Spinal Cord Injury; Commissioning of This Report; Review Questions; Anticipated Challenges for This Task Order; The Collaborative Team 05chap2.doc Microsoft Word® Document MS Word® 2002 48KB 6 pages Contents: Chapter 2. Methodology: Introduction; Technical Expert Panel; Consultations With the Task Order Officer and Partners; Peer Reviewers; Topic Assessment and Refinement; Screening Process; Data Extraction Process; Data Synthesis 06chap3.doc Microsoft Word® Document MS Word® 2002 34KB 3 pages Contents: Chapter 3. General Results: Results of the Literature Search; Results of the Screening Process; General Characteristics of All Included Studies 07chap4.doc Microsoft Word® Document MS Word® 2002 141KB 9 pages Contents: Chapter 4. Diagnosis, Assessment and Natural History of Pain After Traumatic Spinal Cord Injury: Background; Methods; Results; Discussion 08chap5.doc Microsoft Word® Document MS Word® 2002 104KB 6 pages Contents: Chapter 5. Pharmacological Interventions: Background; Results; Implications for Practice 09chap6.doc Microsoft Word® Document MS Word® 2002 135KB 7 pages Contents: Chapter 6. Spinal Cord and Deep Brain Stimulation Techniques: Introduction; Types of Stimulation; Methods; Results; Discussion 10chap7.doc Microsoft Word® Document MS Word® 2002 118KB 6 pages Contents: Chapter 7. Dorsal Root Entry Zone Lesions and Other Surgical Interventions: Introduction; Methods; Results; Discussion 11chap8.doc Microsoft Word® Document MS Word® 2002 32KB 3 pages Contents: Chapter 8. Conclusions and Implications for Future Research: General Implications for Research; Limitations of This Task Order Report; Closing Remarks 12refs.doc Microsoft Word® Document MS Word® 2002 101KB 9 pages Contents: References 13et3-1.doc Microsoft Word® Document MS Word® 2002 35KB 1 page Contents: Evidence Table 3.1: Electronic Database Search Yield 14et3-1a.doc Microsoft Word® Document MS Word® 2002 26KB 1 page Contents: Evidence Table 3.1a: Sensitivity and Specificity of Electronic Database Searches 15et3-2.doc Microsoft Word® Document MS Word® 2002 34KB 2 pages Contents: Evidence Table 3.2: Results of Screening Process 16et3-3.doc Microsoft Word® Document MS Word® 2002 42KB 1 page Contents: Evidence Table 3.3: Screening of Articles in Languages Other Than English Requiring Translation 17et3-4.doc Microsoft Word® Document MS Word® 2002 54KB 3 pages Contents: Evidence Table 3.4: Studies with Multiple Citations 18et3-5.doc Microsoft Word® Document MS Word® 2002 48KB 2 pages Contents: Evidence Table 3.5: Citations of Studies Excluded During Data Extraction 19et3-6.doc Microsoft Word® Document MS Word® 2002 266KB 11 pages Contents: Evidence Table 3.6.1: Year of Publication; Evidence Table 3.6.2: Source of Funding; Evidence Table 3.6.3: Country of Publication; Evidence Table 3.6.4: Study Design; Evidence Table 3.6.5: Direction of Investigation; Evidence Table 3.6.6: Patients in Study Sample; Evidence Table 3.6.7: Patients in Study Sample With TSCI/CNP; Evidence Table 3.6.8: Health Care Setting; Evidence Table 3.6.9: Eligibility Criteria Reported; Evidence Table 3.6.10: Study Duration Preplanned; Evidence Table 3.6.11: Preplanned Study Duration for One Patient; Evidence Table 3.6.12: Number of Groups; Evidence Table 3.6.13: Interventions; Evidence Table 3.6.14: Level of Injury; Evidence Table 3.6.15: Completeness of Injury; Evidence Table 3.6.16: Classification; Evidence Table 3.6.17: Cause of Injury; Evidence Table 3.6.18: Surgical Stabilization; Evidence Table 3.6.19: Time Since Injury; Evidence Table 3.6.20: Age; Evidence Table 3.6.21: Gender; Evidence Table 3.6.22: Neuropathic Pain Defined by Authors; Evidence Table 3.6.23: Cause of Injury; Evidence Table 3.6.24: Start of Pain After Injury; Evidence Table 3.6.25: Duration of Pain; Evidence Table 3.6.26: Area of Body Affected by Pain; Evidence Table 3.6.27: Temporal Properties of Pain; Evidence Table 3.6.28: Siddall Classification of Pain; Evidence Table 3.6.29: Outcome Measures; Evidence Table 3.1.30: Relaxation Techniques; Evidence Table 3.1.31: Laughing 20et4-1.doc Microsoft Word® Document MS Word® 2002 66KB 7 pages Contents: Evidence Table 4.1: Characteristics of Studies Assessing Central Neuropathic Pain; Supplemental Evidence Table 4.1: Other Studies Addressing the Prevalence of and Factors Associated with Neuropathic Pain: Shoulder Hand Syndrome (SHS) 21et4-2.doc Microsoft Word® Document MS Word® 2002 35KB 2 pages Contents: Evidence Table 4.2: Characteristics of Studies Evaluating Outcome Tools for Central Neuropathic Pain 22et4-3.doc Microsoft Word® Document MS Word® 2002 215KB 24 pages Contents: Evidence Table 4.3: Characteristics of Studies Addressing the Prevalence of and Factors Associated With CNP 23et4-3s.doc Microsoft Word® Document MS Word® 2002 116KB 11 pages Contents: Supplemental Evidence Table 4.3: Other Studies Addressing the Prevalence of and Factors Associated with Neuropathic Pain: Shoulder Hand Syndrome (SHS); Supplemental Evidence Table 4.3: Other Studies Addressing the Prevalence of and Factors Associated with Neuropathic Pain: Post-traumatic Syringomeylia; Supplemental Evidence Table 4.3: Other Studies Addressing the Prevalence of and Factors Associated with Neuropathic Pain: Reflex Sympathetic Dystrophy Syndrome (RSDS); Supplemental Evidence Table 4.3: Other Studies Addressing the Prevalence of and Factors Associated with Neuropathic Pain: Hyperpathia; Supplemental Evidence Table 4.3: Other Studies Addressing the Prevalence of and Factors Associated with Neuropathic Pain: Phantom Pain; Supplemental Evidence Table 4.3: Other Studies Addressing the Prevalence of and Factors Associated with Neuropathic Pain: Chronic Cyclical Pain 24et4-4.doc Microsoft Word® Document MS Word® 2002 38KB 2 pages Contents: Evidence Table 4.4: Estimates of Prevalence of CNP in a Community Sample 25et4-5.doc Microsoft Word® Document MS Word® 2002 63KB 3 pages Contents: Evidence Table 4.5: Studies Generating or Testing Hypotheses About Chronic Neuropathic Pain in SCI 26et5-1.doc Microsoft Word® Document MS Word® 2002 121KB 12 pages Contents: Studies of Pharmacological Interventions: Evidence Table 5.1.1: Opioids (Alfentanil), Ketamine; Evidence Table 5.1.2: Opioids (Morphine), Buprenorphine, Clonidine; Evidence Table 5.1.3: Opioids (Morphine), Amitriptyline, Clonazepam, Others; Evidence Table 5.1.4: Anticonvulsants (Valproate); Evidence Table 5.1.5: Anticonvulsants (Gabapentine); Evidence Table 5.1.6: Local Anesthetics and Drugs With Anesthetic Properties (Mexiletine); Evidence Table 5.1.7: Local Anesthetics and Drugs With Anesthetic Properties (Lidocaine); Evidence Table 5.1.8: Adrenergics and Cholinergic Agonists (Clonidine); Evidence Table 5.1.9: Baclofen; Evidence Table 5.1.10: Trazodone Hydrocloride; Evidence Table 5.1.11: Combination-Pharmacological (Amitriptyline + Carbamazepine) and Nonpharmacological Treatment (Electroacupuncture); Evidence Table 5.1.12: Combination- Pharmacological (Melitracen + Flupenthixol) and Nonpharmacological Treatment (TENS) 27et5-1s.doc Microsoft Word® Document MS Word® 2002 142KB 15 pages Contents: Studies of Pharmacological Interventions: Supplemental Evidence Table 5.1.1: Opioids (Morphine) and Clonidine; Supplemental Evidence Table 5.1.2: Aminopyridine; Supplemental Evidence Table 5.1.3: Baclofen; Supplemental Evidence Table 5.1.4: Baclofen; Supplemental Evidence Table 5.1.5: Carbamazepine; Supplemental Evidence Table 5.1.6: Local Anesthetics (Lidocaine); Supplemental Evidence Table 5.1.7: Local Anesthetic (Midazolam); Supplemental Evidence Table 5.1.8: Amitriptyline, Carbamazepine; Supplemental Evidence Table 5.1.9: Amitriptyline Plus Other Nonpharmacologics; Supplemental Evidence Table 5.1.10: Amitriptyline Plus Other Nonpharmacologics; Supplemental Evidence Table 5.1.11: Carbamazepine, Clonipramine; Supplemental Evidence Table 5.1.12: Combination (Buprenorphine, Diazepam, Thiamylal); Supplemental Evidence Table 5.1.13: Combination (Gabapentin and Clonazepam); Supplemental Evidence Table 5.1.14: Combination (Gabapentin, Tramadol, Flunitrazepam); Supplemental Evidence Table 5.1.15: Other (Aspirin in Chloroform) 28et5-2.doc Microsoft Word® Document MS Word® 2002 46KB 2 pages Contents: Evidence Table 5.2: Pharmacologic Studies Sorted by Study Design 29et6-1.doc Microsoft Word® Document MS Word® 2002 58KB 5 pages Contents: Evidence Table 6.1: Characteristics of Studies Using Spinal Cord Stimulation 30et6-1s.doc Microsoft Word® Document MS Word® 2002 124KB 12 pages Contents: Supplemental Evidence Table 6.1: Characteristics of Case Studies Using Spinal Cord Stimulation 31et6-2.doc Microsoft Word® Document MS Word® 2002 91KB 6 pages Contents: Evidence Table 6.2: Characteristics of Studies Using Brain Stimulation; Supplemental Evidence Table 6.2: Characteristics of Case Studies Using Brain Stimulation 32et6-3.doc Microsoft Word® Document MS Word® 2002 37KB 2 pages Contents: Evidence Table 6.3: Characteristics of Studies Using Transcutaneous Electrical Nerve Stimulation (TNS) for Treatment of Pain 33et7-1.doc Microsoft Word® Document MS Word® 2002 75KB 9 pages Contents: Evidence Table 7.1: Characteristics of Studies for Dorsal Root Entry Zone (DREZ) Interventions 34et7-1s.doc Microsoft Word® Document MS Word® 2002 75KB 5 pages Contents: Supplemental Evidence Table 7.1: Characteristics of Studies for Dorsal Root Entry Zone (DREZ) Interventions 35et7-2.doc Microsoft Word® Document MS Word® 2002 81KB 10 pages Contents: Evidence Table 7.2: Characteristics of Studies Evaluating Other Spinal Surgical Procedures; Supplemental Evidence Table 7.2: Case Reports of Other Spinal Surgical Technologies 36biblio.doc Microsoft Word® Document MS Word® 2002 243KB 28 pages Contents: Bibliography 37appa.doc Microsoft Word® Document MS Word® 2002 22KB 1 page Contents: Appendix A. Consortium for Spinal Cord Medicine Member Organizations 38appb.doc Microsoft Word® Document MS Word® 2002 47KB 5 pages Contents: Appendix B. Personnel 39appc.doc Microsoft Word® Document MS Word® 2002 28KB 2 pages Contents: Appendix C. Peer Reviewers for the Management of Chronic Central Neuropathic Pain Following Traumatic Spinal Cord Injury 40appd.doc Microsoft Word® Document MS Word® 2002 23KB 1 page Contents: Appendix D. Final Search Strategy for Primary Studies 41appe.doc Microsoft Word® Document MS Word® 2002 44KB 5 pages Contents: Appendix E. Assessment and Natural History Study Form 42appf.doc Microsoft Word® Document MS Word® 2002 27KB 2 pages Contents: Appendix F. Acronyms and Abbreviations __________________________________________________________________________________________________________
AHRQ Publication No. 01-E063
Current as of September 2001
Internet Citation:
Management of Chronic Central Neuropathic Pain Following Traumatic Spinal Cord Injury. File Inventory, Evidence Report/Technology Assessment Number 45. AHRQ Publication No. 01-E063, September 2001. Agency for Healthcare Research and Quality, Rockville, MD. http://www.ahrq.gov/clinic/scinjinv.htm
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