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BRCA2
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BRCA2Breast cancer 2, early onset What is the normal function of the BRCA2 gene?The BRCA2 gene is a tumor suppressor gene involved in the repair of chromosomal damage. Tumor suppressor genes regulate the cycle of cell division by keeping cells from growing and dividing too rapidly or in an uncontrolled way. Although the structures of the BRCA1 and BRCA2 genes are very different, their functions appear to be similar. The proteins made by both genes are essential for repairing damaged DNA. The BRCA2 protein binds to and regulates the protein produced by the RAD51 gene to fix breaks in DNA. These breaks can be caused by natural and medical radiation or other environmental exposures, but also occur when chromosomes exchange genetic material during a special type of cell division that creates sperm and eggs (meiosis). The BRCA1 protein also interacts with the RAD51 protein. By repairing DNA, these three proteins play a role in maintaining the stability of the human genome. Like BRCA1, BRCA2 probably regulates the activity of other genes and plays a critical role in embryo development. These genes interact to repair damaged DNA. What conditions are related to the BRCA2 gene?
Where is the BRCA2 gene located?13q12.3
The BRCA2 gene is located on the long (q) arm of chromosome 13 at position 12.3. See How do geneticists indicate the location of a gene? in the Handbook. Where can I find information about BRCA2?You and your healthcare professional may find the following resources about BRCA2 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the BRCA2 gene or gene products?
See How are genetic conditions and genes named? in the Handbook. Where can I find general information about genes?The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful. What glossary definitions help with understanding BRCA2?anemia ; base pair ; bone marrow ; cancer ; cell division ; chromosome ; deletion ; DNA ; DNA base ; embryo ; gene ; genome ; homologs ; insertion ; leukemia ; meiosis ; mutation ; prostate ; protein ; Radiation ; susceptibility ; tumor ; tumor suppressor gene You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook. |