Clinical Trial: Brain Tissue Collection for Neuropathological Studies


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Brain Tissue Collection for Neuropathological Studies

This study is currently recruiting patients.

Sponsored by:	National Institute of Mental Health (NIMH)
Information provided by:	Warren G Magnuson Clinical Center (CC)

Purpose

The purpose of this study is to collect and study the brain tissue of deceased individuals to learn more about the nervous system and mental disorders. Information gained from donated tissue may lead to better treatments and potential cures for nervous system and mental disorders.

This study will ask relatives of deceased individuals to donate the brains of their deceased relatives to allow further study of neurological and psychiatric disorders.

Condition
Bipolar Disorder Huntington Disease Schizophrenia Tourette Syndrome Dementia

Study Type: Observational
Study Design: Natural History

Official Title: Brain Procurement for the Neuropathology Section, CBDB

Further Study Details:

Expected Total Enrollment: 1250

Study start: May 29, 1990

The knowledge of how affected tissue deviates from normal control tissue is an integral part of fully understanding a neurological or psychiatric disorder. The purpose of this protocol is to establish a coordinating program with the pathology departments of the Washington, D.C. and metropolitan area hospitals and local medical examiner's offices for the donation of brain tissue.

Eligibility

Genders Eligible for Study: Both

Accepts Healthy Volunteers

Criteria

INCLUSION CRITERIA:
Individuals suffering from a variety of neuropsychiatric disorders, especially schizophrenia, but also Huntington's chorea, suicide, manic-depressive illness, depression, Tourette's Syndrome, drug addictions (PCP, cocaine, alcohol, heroin or the like) and any form of dementia.
Brain tissue from afflicted individuals is needed for the study.
Brains (fresh or preserved tissue) from normal individuals without a history of neuropsychiatric disease.

Location and Contact Information

Maryland
National Institute of Mental Health (NIMH), 9000 Rockville Pike, Bethesda, Maryland, 20892, United States; Recruiting

Joel E. Kleinman, M.D. 3014027909 kleinmaj@intra.nimh.nih.gov

More Information

Detailed Web Page

Publications

Ohuoha DC, Knable MB, Wolf SS, Kleinman JE, Hyde TM. The subnuclear distribution of 5-HT3 receptors in the human nucleus of the solitary tract and other structures of the caudal medulla. Brain Res. 1994 Feb 21;637(1-2):222-6.

Hitri A, Casanova MF, Kleinman JE, Wyatt RJ. Fewer dopamine transporter receptors in the prefrontal cortex of cocaine users. Am J Psychiatry. 1994 Jul;151(7):1074-6.

Wolf SS, Hyde TM, Moody TW, Saunders RC, Weinberger DR, Kleinman JE. Autoradiographic characterization of 125I-neurotensin binding sites in human entorhinal cortex. Brain Res Bull. 1994;35(4):353-8.

Study ID Numbers: 900142; 90-M-0142
Record last reviewed: May 28, 2004
Last Updated: May 28, 2004
Record first received: November 3, 1999
ClinicalTrials.gov Identifier: NCT00001260
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2004-11-08

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National Institutes of Health, Department of Health & Human Services