This study will compare the long-term effectiveness of Clinician-Managed Interpersonal Psychotherapy (CM-IPT) and standard IPT for treatment of postpartum depression. It will also evaluate the acute effectiveness of CM-IPT for postpartum depression.

CM-IPT is delivered in 12 sessions over the course of a year. Standard IPT is delivered in 12 sessions in the first 12 weeks after treatment assignment.

Ages Eligible for Study:  18 Years and above,  Genders Eligible for Study:  Female

Accepts Healthy Volunteers

Criteria

Inclusion criteria:

• Women between 8 and 24 weeks postpartum
• Meet DSM-IV criteria for Major Depression
• Hamilton Rating Scale for Depression score of 12 or more

Exclusion criteria:

• Active substance abuse
• Psychotic disorders