ABT-751 in Treating Young Patients With Refractory Solid Tumors
This study is currently recruiting patients.
Purpose
RATIONALE: Drugs used in chemotherapy, such as ABT-751, work in different ways to stop tumor cells from dividing so they stop
growing or die.
PURPOSE: Phase I trial to study the effectiveness of ABT-751 in treating young patients who have refractory solid tumors.
Condition
|
Treatment or Intervention |
Phase |
childhood cancer
|
Drug: ABT-751 Procedure: chemotherapy
|
Phase I
|
MedlinePlus consumer health information
Study Type: Interventional
Study Design: Treatment
Official Title: Phase I Study of 7-Day or 21-Day ABT-751 in Children With Refractory Solid Tumors
Further Study Details:
OBJECTIVES: Primary
- Determine the maximum tolerated dose and dose-limiting toxic effects of ABT-751 administered daily for 7 days every 21 days
or daily for 21 days every 28 days in children with refractory solid tumors.
- Determine the toxicity spectrum of these regimens in these patients.
- Determine the pharmacokinetics of these regimens in these patients.
- Evaluate the pharmacodynamics of this drug by measuring the fraction of tubulin that is polymerized in the peripheral blood
mononuclear cells of these patients before and after receiving this drug.
Secondary
- Quantify responses in patients treated with these regimens.
- Assess the effect of this drug on tumor vascularity and tumor blood flow using dynamic enhanced MRI in these patients.
OUTLINE: This is an open-label, multicenter, dose-escalation study of 2 different schedules of ABT-751. Patients are assigned
to 1 of 2 dosing schedules.
- Schedule 1: Patients receive oral ABT-751 once daily on days 1-7. Courses repeat every 21 days in the absence of disease progression
or unacceptable toxicity.
- Schedule 2: Patients receive oral ABT-751 once daily on days 1-21. Courses repeat every 28 days in the absence of disease
progression or unacceptable toxicity. On each schedule, cohorts of 3-6 patients receive escalating doses of ABT-751 until
the maximum tolerated dose (MTD) is determined. The MTD is defined as the dose preceding that at which at least 2 of 6 patients
experience dose-limiting toxicity. Once the MTD is determined, up to 9 patients (a minimum of 3 patients age 11 and under
and 3 patients age 12 to 18) are treated at the MTD.
PROJECTED ACCRUAL: A maximum of 48 patients (24 per dosing schedule) will be accrued for this study within 1-2 years.
Eligibility
Ages Eligible for Study:
up to 18 Years,
Genders Eligible for Study:
Both
DISEASE CHARACTERISTICS:
- Histologically confirmed solid tumor, including, but not limited to, the following:
- Rhabdomyosarcoma
- Other soft tissue sarcomas
- Ewing's sarcoma family of tumors
- Osteosarcoma
- Neuroblastoma
- Wilms' tumor
- Hepatic tumors
- Germ cell tumors
- Primary brain tumors
- Brain stem or optic gliomas (histological confirmation may be waived if a biopsy has not been performed)
- Relapsed after or failed to respond to frontline standard therapy and no other standard treatment options (e.g., surgery,
radiotherapy, chemotherapy, or any combination of these modalities) exist
- Measurable or evaluable disease* NOTE: *Not required for patients with neuroblastoma
- No CNS tumor with motor or sensory deficits that would obscure the study assessment of sensory neuropathy
PATIENT CHARACTERISTICS: Age:
Performance status:
- Lansky 60-100% (age 10 and under)
- Karnofsky 60-100% (age 11 to 18)
Life expectancy:
Hematopoietic:
- Absolute neutrophil count at least 1,500/mm^3
- Platelet count at least 100,000/mm^3
Hepatic:
- Bilirubin no greater than 1.5 times upper limit of normal (ULN)
- ALT and AST no greater than 2.5 times ULN
- No clinically significant hepatic dysfunction
Renal:
- Creatinine normal for age OR
- Creatinine clearance at least 60 mL/min
- No clinically significant renal dysfunction
Cardiovascular:
- LVEF normal by echocardiogram
Other:
- Not pregnant or nursing
- Negative pregnancy test
- Fertile patients must use effective contraception
- No allergy to sulfa-containing medications
- No clinically significant unrelated systemic illness (e.g., other organ dysfunction) that would preclude study participation
- No serious infection
- No preexisting grade 2 or greater sensory or motor neuropathy
- Able to swallow intact capsules
- HIV negative
PRIOR CONCURRENT THERAPY: Biologic therapy:
- At least 4 months since prior bone marrow transplantation
- At least 72 hours since prior interleukin-11
- At least 72 hours since prior colony-stimulating factors (e.g., filgrastim [G-CSF] or sargramostim [GM-CSF]) except epoetin
alfa
- No concurrent growth factors (e.g., GM-CSF) except epoetin alfa
- Concurrent G-CSF allowed if neutropenia lasts longer than 5 days OR if the patient experiences confirmed septicemia associated
with neutropenia
- No concurrent immunotherapy
- No concurrent interleukin-11
Chemotherapy:
- See Disease Characteristics
- At least 30 days since prior chemotherapy (42 days for nitrosoureas)
- No other concurrent anticancer chemotherapy
Endocrine therapy:
- Patients with brain tumors:
- Must be on a stable or tapering dose of corticosteroids for 7 days before baseline scan performed for the purpose of assessing
response to study therapy
- Concurrent corticosteroids allowed for control of symptoms of tumor-associated edema
Radiotherapy:
- See Disease Characteristics
- At least 4 weeks since prior radiotherapy
- At least 4 months since prior extensive radiotherapy (craniospinal radiotherapy, total body irradiation, or radiotherapy to
more than 50% of the pelvis)
- No concurrent radiotherapy
Surgery:
- See Disease Characteristics
Other:
- Recovered from prior therapy
- At least 30 days since prior investigational anticancer therapy
- No other concurrent investigational agents
Location
and Contact
Information
Illinois Children's Memorial Hospital - Chicago, Chicago,
Illinois,
60614,
United States; Recruiting
Susan Lerner Cohn, MD
773-880-4562
Maryland Warren Grant Magnuson Clinical Center - NCI Clinical Studies Support, Bethesda,
Maryland,
20892-1182,
United States; Recruiting
NCI Clinical Studies Support
888-NCI-1937
Pennsylvania Children's Hospital of Philadelphia, Philadelphia,
Pennsylvania,
19104-4318,
United States; Recruiting
Study chairs or principal investigators
Frank Milton Balis, MD, Principal Investigator, NCI - Pediatric Oncology Branch
More Information
Clinical trial summary from the National Cancer Institute's PDQ® database
Study ID Numbers:
CDR0000069344; NCI-02-C-0141F; ABBOTT-M01-357
Record last reviewed:
September 2004
Record first received:
May 13, 2002
ClinicalTrials.gov Identifier:
NCT00036959Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2004-11-08