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Phase II Study of Methylprednisolone and Xylose Absorption in Children with Hypersensitivity Vasculitis Associated with Connective Tissue Disease
This study is currently recruiting patients.
Sponsored by: | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) Children's Memorial Hospital, Chicago
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Information provided by: | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) |
Purpose
OBJECTIVES: I. Assess xylose absorption and blood levels of neopterin and von Willebrand factor antigen in children with active hypersensitivity vasculitis associated with connective tissue disease. II. Correlate the bioavailability and kinetic rate constant of absorption of oral methylprednisolone with that of xylose. III. Compare the bioavailability and kinetic rate constant of absorption of oral methylprednisolone during active and quiescent disease in the same child.
Condition | Treatment or Intervention | Phase |
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Vasculitis, Hypersensitivity Connective Tissue Diseases Dermatomyositis Vasculitis |
Drug: Methylprednisolone |
Phase II |
MedlinePlus related topics: Allergy; Connective Tissue Disorders; Myositis; Vasculitis
Study Type: Interventional
Study Design: Treatment, Bio-availability Study
Expected Total Enrollment: 24
Study start: September 1997
PROTOCOL OUTLINE: Following a 12-hour fast, patients receive oral xylose and 2 hours later, oral methylprednisolone. The following day, patients receive intravenous methylprednisolone. Pharmacokinetic studies are performed each day. Patients are re-treated when disease becomes inactive (6-12 months later).
Eligibility
Ages Eligible for Study: 4 Years - 18 Years, Genders Eligible for Study: Both
Criteria
Inclusion Criteria:
Exclusion Criteria:
Location and Contact Information
More Information
U.S. National Library of Medicine, Contact NLM Customer Service | ||||||||||||||
National Institutes of Health, Department of Health & Human Services | ||||||||||||||
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