Many genes are thought to contribute to rheumatoid arthritis (RA). Currently only one such gene has been identified. This study will attempt to identify all of the genes that may contribute to RA and determine which specific genetic variations are responsible for the disease.

The identification of genes for complex disorders such as RA requires large numbers of genetically informative families. This study will enroll patients with RA and their families.

Participants with RA will be evaluated by a study official at his or her doctor's office or other location convenient for the participant. Participants will have a brief interview and physical exam and a blood sample will be obtained. Disease evaluation will be done at one visit and will include a 28 joint count, joint alignment and mobility score (JAMS), hand X-ray, administration of a health assessment questionnaire and other related questionnaires. Physician confirmation of diagnosis will also be included in the disease evaluation.

Ages Eligible for Study:  18 Years and above,  Genders Eligible for Study:  Both

Criteria

Inclusion Criteria

• Adult onset, seropositive, erosive rheumatoid arthritis (RA)
• Diagnosis of RA made between 18 and 60 years old
• Both parents alive and willing to participate
• Parents may have diagnosis of RA (affected) or be unaffected

Exclusion Criteria

• Inflammatory bowel disease
• Lupus
• Psoriatic arthritis