Clinical Trial: Genetics of Fibromyalgia


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Genetics of Fibromyalgia

This study is currently recruiting patients.

Sponsored by:	National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Information provided by:	National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

Purpose

The Fibromyalgia Family Study identifies and collects blood samples from families with two or more members affected with Fibromyalgia Syndrome (FMS). The primary goal of the study is to identify genes that predispose people to FMS and/or symptoms related to FMS; identifying these genes may lead to a better understanding of the disease and more effective treatments.

Condition
Fibromyalgia Irritable Bowel Syndrome Chronic Fatigue Syndrome Depression

Study Type: Observational
Study Design: Natural History, Cross-Sectional, Convenience Sample, Retrospective Study

Official Title: Fibromyalgia Family Study Registry

Further Study Details:

Expected Total Enrollment: 560

Study start: September 1999

FMS predominantly affects women and is characterized by chronic widespread musculoskeletal pain, fatigue, sleep disturbance, and multiple tender points on physical examination. The pathophysiological mechanisms underlying FMS are not clearly understood, but neuroendocrine factors seem to be of major importance. Studies of familial association suggest that genetic factors play a role in FMS. This study will establish patterns of genetic linkage in families with FMS.

Participating family members will undergo a brief physical exam (including tender point exam), donate a blood sample, and complete a detailed questionnaire that includes experience with pain, fatigue, depression, bowel symptoms, headache, anxiety, and physical limitations. Measurements of serum serotonin and related compounds will also be obtained. To detect genetic factors, a genome-wide linkage scan using 405 microsatellite markers will be performed.

Eligibility

Ages Eligible for Study: 12 Years and above, Genders Eligible for Study: Both

Criteria

Inclusion Criteria

Diagnosed with fibromyalgia according to the criteria of the American College of Rheumatology
Have at least one living family member who has also been diagnosed with fibromyalgia
No other major rheumatological disease

Location and Contact Information

Illinois
University of Illinois at Peoria, Peoria, Illinois, 60612, United States; No longer recruiting

Ohio
Case Western Reserve University, Cleveland, Ohio, 44109, United States; Recruiting

David Ritter 216-368-5653 ffs@darwin.cwru.edu
M. A. Khan, MD, Sub-Investigator
Sudha Iyengar, PhD, Principal Investigator

University of Cincinnati, Cincinnati, Ohio, 45221, United States; Recruiting

Penny Brooks 513-558-9973 brookscp@ucmail.uc.edu
Lesley Arnold, MD, Sub-Investigator

Texas
University of Texas Health Sciences Center, San Antonio, Texas, 78229, United States; No longer recruiting

Study chairs or principal investigators

Sudha Iyengar, PhD, Study Chair, Case Western Reserve University

More Information

Click here for the Fibromyalgia Family Study Web site.

Publications

Yunus MB, Khan MA, Rawlings KK, Green JR, Olson JM, Shah S. Genetic linkage analysis of multicase families with fibromyalgia syndrome. J Rheumatol. 1999 Feb;26(2):408-12.

Study ID Numbers: NIAMS-100
Record last reviewed: October 2004
Record first received: October 14, 2003
ClinicalTrials.gov Identifier: NCT00071162
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2004-11-08

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National Institutes of Health, Department of Health & Human Services