Clinical Trial: Genetics of Ankylosing Spondylitis


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Genetics of Ankylosing Spondylitis

This study is currently recruiting patients.

Sponsored by:	National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Information provided by:	National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

Purpose

Ankylosing spondylitis (AS) is a chronic inflammatory disease that affects the joints between the vertebrae of the spine and the joints between the spine and the pelvis. The purpose of this study is to collect information and blood samples from patients with AS and their relatives for use in genetic studies.

Condition
Spondylitis Ankylosing Spondylitis

Study Type: Observational
Study Design: Natural History, Cross-Sectional, Defined Population, Retrospective/Prospective Study

Official Title: Family Studies of the Genetics of Ankylosing Spondylitis

Further Study Details:

Expected Total Enrollment: 1600

Study start: September 1999; Study completion: June 2004

AS is a chronic inflammatory disease that eventually causes the affected vertebrae to fuse or grow together. The cause of ankylosing spondilitis is unknown, but genetic factors seem to play a role. Risk factors include a family history of ankylosing spondylitis and male gender.

This study will collect patient information and blood samples from affected and unaffected sib pairs (and when available, both parents) of 400 Caucasian families with at least two siblings fulfillling the modified New York criteria for AS. Diagnosis of AS will be verified by patient questionnaire, medical record review, and pelvic radiographs. Information from these patients will be used to search the human genome for disease-associated loci and/or genes. This study will also utilize contributions of investigators who have conducted recent clinical or genetic research in AS at 10 academic medical centers throughout North America (the North American Spondylitis Consortium, or NASC).

Eligibility

Genders Eligible for Study: Both

Accepts Healthy Volunteers

Criteria

Inclusion Criteria:

Meet modified New York criteria for ankylosing spondylitis (AS)
AS as confirmed by X-rays of sacroiliac joints (between the pelvis and spine)
At least two siblings in family with AS

Location and Contact Information

Spondylitis Association of America Clinical Coordinating Center (800) 777-8189 info@asresearch.org
Laura Diekman 713-500-6854 laura.diekman@uth.tmc.edu

California
Cedars-Sinai Medical Center, Los Angeles, California, 90048, United States; Recruiting

Erin Skrok 310-423-3032 skroke@cshs.org
Michael Weisman, MD, Principal Investigator

Texas
University of Texas - Health Science Center at Houston, Houston, Texas, 77030, United States; Recruiting

Laura Diekman 713-500-6854 laura.diekman@uth.tmc.edu
John D. Reveille, MD, Principal Investigator

Study chairs or principal investigators

John D. Reveille, MD, Principal Investigator, University of Texas - Health Science Center at Houston

More Information

Click here for the North American Spondylitis Consortium [NASC] Web site.

Click here for the Spondylitis Association of America Web site.

Publications

Brown MA, Wordsworth BP, Reveille JD. Genetics of ankylosing spondylitis. Clin Exp Rheumatol. 2002 Nov-Dec;20(6 Suppl 28):S43-9. Review.

Tsui FW, Tsui HW, Cheng EY, Stone M, Payne U, Reveille JD, Shulman MJ, Paterson AD, Inman RD. Novel genetic markers in the 5'-flanking region of ANKH are associated with ankylosing spondylitis. Arthritis Rheum. 2003 Mar;48(3):791-7.

Reveille JD. The genetic basis of spondyloarthritis. Curr Rheumatol Rep. 2004 Apr;6(2):117-25.

Study ID Numbers: NIAMS-098; 5R01 AR046208-05; NASC
Record last reviewed: September 2004
Record first received: April 15, 2004
ClinicalTrials.gov Identifier: NCT00081562
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2004-11-08

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