Clinical Trial: Evaluation of Patients with Thyroid Disorders


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Evaluation of Patients with Thyroid Disorders

This study is currently recruiting patients.

Sponsored by:	National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Information provided by:	Warren G Magnuson Clinical Center (CC)

Purpose

Participants in this study will be patients diagnosed with or suspected to have a thyroid function disorder. These conditions may include: hypothyroidism, hyperthyroidism, thyroid hormone resistance, Graves' Dermopathy, and thyroid-stimulating hormone (TSH) secreting pituitary adenomas.

The main purpose of this study is to further understand the natural history, clinical presentation, and genetics of thyroid function disorders. Many of the tests performed are in the context of standard medical care that is offered to all patients with thyroid function disorders. In addition, blood and tissue samples may be taken for research and genetic studies.

Condition
Hyperthyroidism Hypothyroidism Pituitary Neoplasm

Study Type: Observational
Study Design: Natural History

Official Title: Evaluation of Patients with Thyroid Function Disorders

Further Study Details:

Expected Total Enrollment: 9999

Study start: January 14, 1977

Patients with thyroid function abnormalities (hyperthyroidism, hypothyroidism) are studied and treated in this protocol. A limited number of patients with a personal history of signs, symptoms or laboratory studies consistent with thyroid dysfunction or a strong family history of thyroid abnormalities are also enrolled. Patients undergo routine history and physical examination, standard endocrine blood and urine tests, a standard TRH test, thyroid nuclear medicine scans, thyroidal radioiodine (RAI) or technetium (99mTc) uptake measurements, as well as X-ray, computed tomography (CT) or magnetic resonance imaging (MRI) studies or other standard diagnostic procedures, as clinically indicated. Patients will be screened for entry into other research studies.

Eligibility

Genders Eligible for Study: Both

Accepts Healthy Volunteers

Criteria

INCLUSION CRITERIA:
Patients of any age with known or suspected thyroid abnormalities may be included in this study. These disorders can be broadly defined as hyper- or hypothyroid states and laboratory abnormalities.

Location and Contact Information

Maryland
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), 9000 Rockville Pike, Bethesda, Maryland, 20892, United States; Recruiting

Patient Recruitment and Public Liaison Office 1-800-411-1222 prpl@mail.cc.nih.gov
TTY 1-866-411-1010

More Information

Detailed Web Page

Publications

Holland FW 2nd, Brown PS Jr, Weintraub BD, Clark RE. Cardiopulmonary bypass and thyroid function: a "euthyroid sick syndrome". Ann Thorac Surg. 1991 Jul;52(1):46-50.

Chanson P, Weintraub BD, Harris AG. Octreotide therapy for thyroid-stimulating hormone-secreting pituitary adenomas. A follow-up of 52 patients. Ann Intern Med. 1993 Aug 1;119(3):236-40.

Brucker-Davis F, Skarulis MC, Grace MB, Benichou J, Hauser P, Wiggs E, Weintraub BD. Genetic and clinical features of 42 kindreds with resistance to thyroid hormone. The National Institutes of Health Prospective Study. Ann Intern Med. 1995 Oct 15;123(8):572-83.

Study ID Numbers: 770002; 77-DK-0002
Record last reviewed: January 9, 2004
Last Updated: January 9, 2004
Record first received: November 3, 1999
ClinicalTrials.gov Identifier: NCT00001159
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2004-11-08

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National Institutes of Health, Department of Health & Human Services