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Cause of Focal Segmental Glomerulosclerosis
This study is currently recruiting patients.
Sponsored by: | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) |
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Information provided by: | Warren G Magnuson Clinical Center (CC) |
Purpose
Focal Segmental Glomerulosclerosis (FSGS) is a disease of the kidney. Presently, the cause of FSGS is unknown. However, some researchers believe that the disease may be caused by an infection, possibly a virus. The reasons for thinking this is that a form of FSGS has been associated with certain viral infections such as Human Immunodeficiency Virus (HIV).
Study participation involves giving blood and urine samples. In addition, researchers will study previous biopsy results. All samples will undergo extensive genetic tests to determine if a virus or viral infection exists.
Condition |
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AIDS Associated Nephropathy Focal Glomerulosclerosis HIV Infections |
MedlinePlus related topics: AIDS; Kidney Diseases
Study Type: Observational
Study Design: Natural History
Official Title: Pathogenesis of Focal Segmental Glomerulosclerosis
Expected Total Enrollment: 9999
Study start: April 7, 1994
Focal segmental glomerulosclerosis (FSGS) represents a clinicopathologic syndrome, including nephrotic syndrome and a typical renal histologic appearance. FSGS occurs in an idiopathic form and in association with HIV-1 infection, as well as in association with conditions that lead to glomerular hyperfiltration. HIV-associated FSGS affects African-Americans to a disproportionate degree, suggesting that host genetic factors contribute to this complication. Nevertheless, only approximately 10% of African-Americans develop HIV-associated FSGS and it is possible that particular HIV-1 strains are renotropic (localize to kidney) or nephrotoxic (injure kidney). HIV-associated FSGS has particular histologic features that serve to distinguish it from other forms of FSGS; these include glomerular collapse and hypertrophy of glomerular epithelial cells. Recently a new syndrome has been recognized, in which patients have this collapsing variant of FSGS in the absence of serologically-defined HIV-1 infection. We propose two hypotheses: 1) that the pathogenic role of HIV-1 in causing FSGS may be due to variation in certain viral genomic regions, particularly envelope and the accessory genes
2) that other viruses may contribute to the pathogenesis of idiopathic FSGS. Laboratory analysis includes 1) sequencing of HIV-1 genome from HIV-1 infected patients with and without kidney disease, and measurement of plasma and urine levels of HIV-1 accessory proteins and 2) amplifying by PCR particular viruses from peripheral blood cells and urine cells; these viruses will include parvovirus B19 and polyoma viruses.
Eligibility
Genders Eligible for Study: Both
Accepts Healthy Volunteers
Criteria
Location and Contact Information
More Information
Publications
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