Kidney diseases related to the immune system include, nephrotic syndrome, glomerulonephritis, membranous nephropathy, lupus nephritis, and nephritis associated with connective tissue disorders.

This study will allow researchers to admit and follow patients suffering from autoimmune diseases of the kidney. It will attempt to provide information about the causes and specific abnormalities associated with autoimmune kidney disease.

Patients with kidney disease as a result of their immune system, and patients with diseases of the immune system who may later develop kidney disease, will be potential subjects for this study.

Patients will undergo a history and physical examination, and standard laboratory test to more closely understand the causes, signs, symptoms, and responses to medication of these diseases. Based on these evaluations the patients may qualify as candidates for other experimental studies. At any time these patients may be asked to submit blood or urine samples for further research.

Condition
Glomerulonephritis Lupus Nephritis Membranous Glomerulonephritis Nephritis Nephrotic Syndrome

Patients with known or suspected immunologically-mediated kidney diseases, including but not limited to, nephrotic syndrome, glomerulonephritis, membranous nephropathy, lupus nephritis, and nephritis associated with other systemic or connective tissue disorders, will be evaluated at the Clinical Center. Patients who have immunologically-mediated diseases with the potential for kidney disease will be evaluated as well. Studies will include characterization of the clinical and laboratory features of these disorders, studies of natural history and complications, evaluation of responses to standard treatment, and determination of the patients' eligibility to enter other experimental diagnostic or therapeutic protocols. Patients may be asked to contribute blood and/or urine samples for immunological research studies.

Genders Eligible for Study:  Both

Criteria

CRITERIA FOR INCLUSION:
Immunologically-mediated renal diseases, proven or suspected.
Immunologically-mediated diseases with potential for kidney disease.
Willingness of the patient or guardian to give informed consent.
EXCLUSION CRITERIA:
Concomitant medical problems which would confound the interpretation of studies of the immunologic kidney disorder.
Concomitant medical, surgical or other conditions for which inadequate facilities or funds are available to support their care at the NIH.

Maryland
      National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), 9000 Rockville Pike,  Bethesda,  Maryland,  20892,  United States; Recruiting

Study ID Numbers:  920156; 92-DK-0156
Record last reviewed:  March 9, 2004
Last Updated:  March 9, 2004
Record first received:  January 20, 2000
ClinicalTrials.gov Identifier:  NCT00001979
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2004-11-08