OBJECTIVES: I. Establish linkage in families with hereditary pancreatitis between the phenotype and a chromosomal locus (loci) that contains the responsible gene.

Condition	Treatment or Intervention
Pancreatitis	Procedure: genetic testing

PROTOCOL OUTLINE: This is a genetics study. Blood samples are collected from patients and family members. DNA is extracted from the blood and used for genotypic analysis and linkage analysis. Patients do not necessarily receive the results of the genetic testing and the results do not influence the type or duration of treatment.

Genders Eligible for Study:  Both

Criteria

• Diagnosis of hereditary pancreatitis with confirmation of phenotype by: Onset of pain before age 20 Amylase elevation at least 2 times normal Surgical or postmortem confirmation of pancreatitis Unequivocal evidence of pancreatic exocrine insufficiency in the absence of trauma, alcohol abuse, elevated serum lipids, or other known causes
• Family member of a patient diagnosed with hereditary pancreatitis

Pennsylvania
      University of Pittsburgh, Presbyterian University Hospital, Pittsburgh,  Pennsylvania,  15213-2582,  United States; Recruiting

Study chairs or principal investigators

David C. Whitcomb,  Study Chair,  University of Pittsburgh   

Study ID Numbers:  199/14042; UPMC-951061; UPMC-R01DK54709-01; UPMC-R03DK51954
Record last reviewed:  July 2004
Record first received:  October 18, 1999
ClinicalTrials.gov Identifier:  NCT00004475
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2004-11-08