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Human Requirements for the Nutrient Choline
This study is currently recruiting patients.
Sponsored by: | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) |
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Information provided by: | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) |
Purpose
The purpose of this research study is to determine how much choline healthy people need to have in their diets. Choline is a normal part of many foods. It is used in the body to make membranes (the wrappers around cells) and to make a nerve chemical called acetylcholine. Several species of animals need to eat choline; otherwise their livers do not work properly. It is not known whether this is so in humans because they may be able to meet their daily choline requirements by making choline in the liver. This study will test whether humans can make sufficient choline or not when they have less than the usual amount in their diet. This study will also examine whether a diet low in another vitamin, folate, will affect how much choline humans require.
Condition | Treatment or Intervention |
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Healthy |
Procedure: Induction of choline deficiency |
MedlinePlus consumer health information
Study Type: Interventional
Study Design: Educational/Counseling/Training, Randomized, Double-Blind, Placebo Control, Parallel Assignment
Expected Total Enrollment: 80
Study start: September 2000
The objective of this study is to determine the required daily amount (RDA) of choline, a nutrient deemed essential for humans, in adult men and women. At this time the Institute of Medicine has suggested an adequate intake, but has not determined the minimum intake of choline. Choline is used to form membranes (phosphatidlycholine), to form a neurotransmitter (acetylcholine), and as a methyl group donor in biochemical reactions. This report noted that choline is important for normal function, and that it is likely that humans require dietary choline. However, they noted that evidence in humans is insufficient to make accurate estimations of this requirement, and that " …research that could provide such human data is assigned the highest priority." The aim of this study is to determine the dietary choline requirement of adult men and women (pre- and postmenopausal).
Eligibility
Ages Eligible for Study: 18 Years - 70 Years, Genders Eligible for Study: Both
Accepts Healthy Volunteers
Criteria
Location and Contact Information
More Information
U.S. National Library of Medicine, Contact NLM Customer Service | ||||||||||||||
National Institutes of Health, Department of Health & Human Services | ||||||||||||||
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