Psychiatry and Substance Abuse

Depression—Newer Pharmacotherapies

March 1999

Clinical Focus*

• Are newer antidepressant agents more effective than placebo or older antidepressant agents for treating adult patients with major depression?
• Are newer antidepressant agents more effective than placebo or older antidepressant agents for treating adult persons with dysthymia?
• Are newer antidepressant agents more effective than placebo or older antidepressant agents for treating adult persons with mixed anxiety depression?
• Are newer antidepressant agents more effective than older antidepressant agents for treating adult patients with subsyndromal depressive disorders?
• Are newer antidepressant agents more effective than older antidepressant agents or placebo in the treatment of recurrent depression?
• Are newer antidepressant agents more effective than older agents in the treatment of adult patients with refractory depression?
• Are newer antidepressive agents more effective than psychosocial therapies for treating depressive disorders in adults?
• Is hypericum (St. John's wort) more effective than placebo or standard antidepressant agents for treating adult patients with depressive disorders?

*Addressed in the summary or evidence report.

Treatment of Depression—Newer Pharmacotherapies
Summary (Publication No. 99-E013, March 1999)
Evidence Report Volume I (Publication No. 99-E014, February 1999)
Selected Publications

EPC: University of Texas HSC
Topic Nominators: National Institute of Mental Health, American Psychiatric Association, American Pharmaceutical Association, Vermont Department of Mental Health/Mental Retardation, Blue Cross Blue Shield of Massachusetts, American College of Physicians, Kaiser Permanente of North Carolina

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