This is a Phase II, exploratory, open-label study of the investigational product AG-858, in patients who are cytogenetically positive after treatment with Gleevec.

The trial will consist of three independent Phase II evaluations of patient groups according to their cytogenetic status as defined in the eligibility criteria (Eligibility Criteria 4a, 4b, and 4c).

Condition	Treatment or Intervention	Phase
Leukemia, Myeloid, Chronic	Drug: Autologous HSP-70 Protein-Peptide Complex (AG-858) Plus Gleevec™.	Phase II

The goals of this study are to determine the following:

• To estimate the proportion of patients with a complete cytogenetic response (CCR) within each patient group
• To estimate the proportion of patients with a substantial molecular response (SMR) within each patient group
• To evaluate the frequency and severity of adverse events.
• To assess the feasibility of AG-858 production.

Ages Eligible for Study:  18 Years and above,  Genders Eligible for Study:  Both

Criteria

Inclusion Criteria:

• Must be Philadelphia chromosome positive chronic myelogenous leukemia in first chronic phase
• Must have a complete hematologic response
• Must have received Gleevec™, IFN-α, cytarabine, busulfan, hydroxyurea, Homoharringtonine (HHT) or any combination thereof as long as the combination has been discontinued and the dosing of Gleevec™ has been stable for 6 months or greater
• Must have one of the following cytogenetic statuses: (A) Less than a CCR after receiving Gleevec™ for at least one year at a minimum dose of 400 mg/day. A stable dose of Gleevec™ must have been maintained for the last six months prior to eligibility testing OR (B) Stable cytogenetic status without CCR (no cytogenic response or progression) in three consecutive determinations over six months while on a stable dose of Gleevec™ (at a minimum of 400mg/day) for at least 6 months OR (C) Cytogenetic progression while on a stable dose of Gleevec™ (at a minimum dose of 400mg/day)for at least 2 consecutive evaluations at least one month apart
• ECOG performance score of 0 or 1
• Must be at least 18 years old
• Not pregnant or breastfeeding and agree to use contraception during the course of the study
• No prior allogeneic bone marrow transplant or be candidates for curative BMT
• No immunodeficiency or other serious illness
• No current use of immunosuppressive medications
• No other cancer within the last five years, with the exception of adequately treated cone-biopsied in situ carcinoma of the cervix uteri or basal or squamous cell carcinoma of the skin

Antigenics Study Staff      866-805-8994    clinicalaffairs@antigenics.com

Alabama
      Birmingham,  Alabama,  United States; Recruiting
California
      Los Angeles,  California,  United States; Recruiting
      La Jolla,  California,  United States; Recruiting
Colorado
      Denver,  Colorado,  United States; Recruiting
Connecticut
      Farmington,  Connecticut,  United States; Recruiting
Illinois
      Chicago,  Illinois,  United States; Recruiting
Massachusetts
      Boston,  Massachusetts,  United States; Recruiting
Missouri
      St. Louis,  Missouri,  United States; Recruiting
New York
      New York City,  New York,  United States; Recruiting
Oregon
      Portland,  Oregon,  United States; Recruiting
Pennsylvania
      Pittsburgh,  Pennsylvania,  United States; Recruiting
United Kingdom
      London,  United Kingdom; Recruiting
      Liverpool,  United Kingdom; Recruiting

Study ID Numbers:  C-300-01
Record last reviewed:  July 2004
Record first received:  April 11, 2003
ClinicalTrials.gov Identifier:  NCT00058747
Health Authority: United States: Food and Drug Administration
ClinicalTrials.gov processed this record on 2004-11-09