CDC Smallpox | Vaccine Safety (Reactions and Adverse Events)

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Smallpox Home > Vaccination >

Smallpox Vaccine Safety (Reactions and Adverse Events)

More information for the public can be found on the Smallpox Vaccine page.

NOTE: Safety concerns to consider before vaccination can be found on the Contraindications & Screening page.

On this page:

•	Normal Reactions & Take Evaluations
•	Basic Descriptions of Adverse Reactions
•	Evaluation, Management, & Treatment

•	Monitoring, Reporting, & Response
•	Updates, Articles, & Reports

Title	Date Last Revised
NORMAL REACTIONS & TAKE EVALUATIONS
Fact Sheet: Reactions after Smallpox Vaccination For the public	Mar 28, 2003
Information on Normal Reactions For clinicans. From the Smallpox Vaccination & Adverse Events Training Module	Mar 10, 2003
Images: Evaluation of Takes & Non-Takes Photographs for clinicans	Feb 28, 2003
Images: More Examples of Major or "Take" Reactions to Smallpox Vaccination Photographs for clinicans	Feb 21, 2003
Images: Comparison of Reactions for First-Time Vaccinees & Revaccinees Photographs for clinicans	Feb 21, 2003
BASIC DESCRIPTIONS OF ADVERSE REACTIONS
Fact Sheet: Reactions after Smallpox Vaccination For the public	Mar 28, 2003
Fact Sheet: Adverse Reactions Following Smallpox Vaccination For clinicians	Mar 28, 2003
Fact Sheet: Smallpox Vaccine & Heart Problems For the public	Mar 31, 2003
Fact Sheet: Smallpox Vaccine & Heart Problems: Information for People Who Have Recently Received the Smallpox Vaccine For recent vaccinees	Mar 31, 2003
Chart: Smallpox Vaccine Adverse Event Rates, 1968	Dec 31, 2002
Q & A: Adverse Events & Vaccine Safety For professionals	May 15, 2003
Training: Smallpox Vaccination & Adverse Events For professionals. Up-to-date training on vaccine, method of vaccination, & normal & adverse reactions.	Mar 10, 2003
Brochure: Smallpox Vaccination Pocket Reference Guide For professionals. Printable brochure depicting both normal & adverse reactions. From the Smallpox Vaccination & Adverse Events Training Module	Feb 26, 2003
EVALUATION, MANAGEMENT, & TREATMENT OF ADVERSE REACTIONS
Fact Sheet: Adverse Reactions Following Smallpox Vaccination For clinicians	Mar 28, 2003
Fact Sheet: Medical Management of Smallpox Vaccine Adverse Reactions For clinicans. Includes information on the two medications (Vaccinia Immune Globulin & Cidofovir) that may help persons who have certain serious reactions to the vaccine	Feb 11, 2003
Clinical Evaluation Tools for Smallpox Vaccine Adverse Reactions Tools for clinicians	Mar 25, 2003
Q & A: Adverse Events & Vaccine Safety For professionals	May 15, 2003
Fact Sheet: Investigational Vaccinia Immune Globulin (VIG) Information VIG—made from blood of people with immunity to smallpox—may help people who have certain serious reactions to the vaccine.	Jan 16, 2003
Fact Sheet: Investigational Vistide® (Cidofovir) Information Cidofovir may help people who have certain serious reactions to the vaccine & is given when VIG is not available or is not working.	Jan 16, 2003
MMWR: Smallpox Vaccination & Adverse Reactions: Guidance for Clinicians MMWR 2003 Feb 21;52(RR04):1-28. PDF (396 KB/24 pages)	Feb 21, 2003
Slide Sets: Smallpox Vaccination & Adverse Reactions Slide sets that review key points in the MMWR report Smallpox Vaccination and Adverse Events: Guidance for Clinicians	Feb 20, 2003
Webcast & Slides: Clinical Management of Adverse Events Following Smallpox Vaccination: A National Training Initiative Originally aired Feb 4, 2003. Info for clinicians on assessment, diagnosis, management, & treatment of patients with suspected adverse events	Feb 6, 2003
Webcast & Slides: Evaluation, Management, & Treatment of Adverse Events Video & slides from CDC Bioterrorism Update: Smallpox Preparedness	Feb 21, 2003
MONITORING, REPORTING, & RESPONSE OF ADVERSE EVENTS
Fact Sheet: Smallpox (Vaccinia) Vaccine Adverse Event Reporting For clinicans	Feb 19, 2003
MMWR: Smallpox Vaccine Adverse Events Monitoring & Response System for the First Stage of the Smallpox Vaccination Program MMWR 2003 Feb 7;52(05):88-89,99. PDF (203 KB/20 pages)	Feb 7, 2003
MMWR: Notice to Readers: National Smallpox Vaccine in Pregnancy Registry MMWR 2003 Mar 28;52(12):256. PDF (1.21 MB/28 pages)	Mar 28, 2003
Vaccine Adverse Event Reporting System (VAERS) Vaccine safety surveillance program of CDC & Food & Drug Administration (FDA).	NA
Smallpox Vaccine VAERS Report Follow-up Worksheet PDF (59 KB/1 page) To be used for follow-up of designated VAERS reports.	Mar 4, 2003 (last reviewed Aug 5, 2004)
Smallpox Vaccine Adverse Event Supplemental Surveillance Worksheet PDF (153 KB/1 page) Worksheet to help health departments track & document the outcome & disposition of persons with adverse events.	Mar 14, 2003 (last reviewed Aug 5, 2004)
Webcast & Slides: Smallpox Vaccine Safety & Reporting Adverse Events Video & slides from CDC Bioterrorism Update: Smallpox Preparedness	Feb 21, 2003
Training: Smallpox Vaccine Adverse Event Workshop for State Health Departments Presentations & training materials from a workshop conducted on Jan 22-23, 2003	Feb 26, 2003
UPDATES, ARTICLES, & REPORTS OF ADVERSE EVENTS
Smallpox Vaccination Adverse Events Report Summary reports on adverse events among civilians. From the CDC Media Relations site.	Aug 28, 2003
MMWR: Updates on Adverse Events Among U.S. Civilians	Feb 13, 2004
MMWR: Secondary & Tertiary Transfer of Vaccinia Virus Among U.S. Military Personnel—United States & Worldwide, 2002–2004 MMWR 2004 Feb 13;53(05):103-105. PDF (268 KB/24 pages)	Feb 13, 2004
Mass Smallpox Vaccination and Cardiac Deaths, New York City, 1947NEW! Emerging Infectious Diseases 2004 May;10(5):917-920. PDF (256 KB/4 pages)	April 23, 2004
Smallpox Vaccination and Adverse Cardiac Events Emerging Infectious Diseases 2004 May;10(5):961-962. PDF (284 KB/2 pages)	April 23, 2004
MMWR: Cardiac Deaths After a Mass Smallpox Vaccination Campaign—New York City, 1947 MMWR 2003 Oct 3;52(39):933-936. PDF (470 KB/20 pages)	Oct 3, 2003
MMWR: Women with Smallpox Vaccine Exposure During Pregnancy Reported to the National Smallpox Vaccine in Pregnancy Registry—United States, 2003 MMWR 2003 May 2;52(17):386-388. PDF (1.19 MB/24 pages)	May 1, 2003
MMWR Update: Cardiac-Related Events During the Civilian Smallpox Vaccination Program — United States, 2003 MMWR 2003 May 30;52(21);492-496. PDF (267 KB/24 pages)	May 30, 2003
MMWR: Cardiac Adverse Events Following Smallpox Vaccination—United States, 2003 MMWR 2003 Mar 28;52(12):248-250. PDF (1.21 MB/28 pages)	Mar 28, 2003
Generalized Vaccinia 2 Days after Smallpox Revaccination Emerging Infectious Diseases 2004 Jan;9(12). PDF (176 KB/2 pages)	Nov 20, 2003
Vaccinia Case Study: Accidental Infection of Laboratory Worker with Vaccinia Virus Emerging Infectious Diseases 2003 June;9(6):724-726. PDF (247 KB/3 pages)	May 5, 2003
Military Update: Safety Summary from DoD Smallpox Vaccination Program From the Department of Defense	Jun 25, 2003



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		Page last modified May 7 , 2004