Technical Abstract: Resistance to the hemi-parasitic weed Striga hermonthica was evaluated in 274 Pennisetum glaucum subsp. monodii accessions in four trials in Mali and Niger from 1997 to 1998. Seventy five accessions were selected from that collection for evaluation in three additional trials in Niger and Nigeria in 2000, and evaluated for maximum number of emerged striga per host plant. Mean striga per plant ranged from 0.2 to 14.9 across the seven trials, and from 0.8 to 8.8 for the 75 selected accessions. Regression analysis of accession mean within a trial vs. trial mean identified 11 accessions with stable resistance (intercepts and slopes not different from zero, P>0.05) over all trials. Nine accessions were classified as resistant (mean = 0, P>0.05) by least squares means calculated from covariance analysis in which downy mildew incidence (caused by Sclerospora graminicola), heading date, and days to striga emergence were significant covariates (P<0.01). Four accessions (PS 202, PS 637, PS 639, and PS 727) were classified as resistant by both regression and covariance analyses, and are likely to be sources of stable striga resistance for cultivated pearl millet in West Africa. In addition to its striga resistance, PS 202 also expressed downy mildew resistance at all locations (mean incidence = 0.8%), in contrast to the three other accessions which were susceptible, with incidence > 83%.