ARS | Publication request: Dietary Phylloquinone Intake As a Potential Marker for a Heart-Healthy Dietary Pattern in the Framingham Offspring Cohort

Submitted to: Journal Of The American Dietetic Association
Publication Acceptance Date: March 1, 2004
Publication Date: September 1, 2004
Publisher's URL: http://www.adajournal.org/scripts/om.dll/search?action=searchft&srch;_fields1=title&srch;_value1=Dieta
Citation: Braam, L.A., Mckeown, N.M., Jacques, P.F., Lichtenstein, A.H., Vermeer, C., Wilson, P.W., Booth, S.L. 2004. Dietary Phylloquinone Intake As A Potential Marker For A Heart-Healthy Dietary Pattern In The Framingham Offspring Cohort. Journal Of The American Dietetic Association. 104(9):1410-1414.

Interpretive Summary: Associations were evaluated among self-reported dietary intakes of vitamin K, lifestyle characteristics and markers of cardiovascular risk in a population-based cohort of men and women. Dietary phylloquinone intakes were assessed by food frequency questionnaire in 1,338 men and 1,603 women participating in the Framingham Heart Study. Participants reporting high intakes of vitamin K were older, were leaner, smoked less, and consumed more fruit, vegetables and dietary supplements and less meat, lower saturated and higher polyunsaturated fat intakes. Higher phylloquinone intakes were also associated with a more favorable lipid profile. In conclusion, high phylloquinone intakes may be marker for an overall heart healthy lifestyle and a more favorable lipid profile.

Technical Abstract: Associations were evaluated among self-reported dietary intakes of phylloquinone (vitamin K1), lifestyle characteristics and intermediary markers of CVD risk in a population-based cohort of men and women. Dietary phylloquinone intakes were assessed by food frequency questionnaire in 1,338 men and 1,603 women (mean age: 54y) participating in the Framingham Heart Study. Cross-sectional associations with lifestyle characteristics and lipid profiles, including total-, LDL- and HDL-cholesterol and triacylglycerol concentrations, were estimated across increasing quintile categories of phylloquinone intakes. Participants in the highest quintile category of phylloquinone intake were older (P<0.001), had lower BMI (P=0.04), smoked less (P<0.001), and consumed more fruit, vegetables and dietary supplements (P<0.001) and less meat, lower saturated and higher polyunsaturated fat intakes(P<0.001). Higher phylloquinone intakes were also associated with lower triacylglycerol (P<0.001) and higher HDL-cholesterol concentrations(P=0.003). In conclusion, high phylloquinone intakes may be marker for an overall heart healthy lifestyle and a more favorable lipid profile.