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No information is available at this time. |
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RFA on Genetic Studies of Obesity-Related Traits in Model Organisms (DK-03-018)—New! |
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Drosophila White Paper 2001 |
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The Drosophila Genome. Science: Vol 287, No. 5461, pp. 2181-2224 and pp.2271-2274. 2000. This issue of Science includes papers on the D. melanogaster genomic sequence: how it was deduced; how it will be finished; what the sequence data reveal about chromosome structure; a comparison of the D. melanogaster, C. elegans and S. cerevisiae genomes; and the relationship between the Drosophila genome and human genes. The issue also includes perspectives on the history of Drosophila's contributions to genome research and implications of the genomic sequence for human biology and medicine, and a description of strategy for generating full-length sequenced cDNAs corresponding to each gene (unigene sets) for Drosophila and other organisms.
There is also an editorial on the significance of the Drosophila genomic sequence (p. 2157) and a perspective on pre- and post-genomic genetics (pp. 2173-2174). The sequence of the D. melanogaster genome has been deposited into GenBank. The URL is: http://www.ncbi.nlm.nih.gov/PMGifs/Genomes/7227.html. Annotation is available at FlyBase. |
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FlyBase is a comprehensive database of the Drosophila genome. It includes genetic and genomic data from the scientific literature, sequence databases, and personal communications. Of particular interest to genomics researchers are searchable databases of sequences, ESTs, clones, transposons/vectors, transcripts/polypeptides, and BLAST searches. Genomic data is correlated with genetic data and cytological maps. |
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The Interactive Fly is a web-based guide to Drosophila genes and their roles in development. Although it is designed for users at all levels, it is useful to genomics researchers because the developmental and genetic data are cross-indexed to the genomic data in FlyBase. |
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Fly/Human Homologue Table is a footnoted table of cloned human genes that are homologous to cloned Drosophila genes. This information should be of interest to genomics researchers who work with either organism who need comparative data. |
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Bloomington Drosophila Stock Center at Indiana University is the centralized D. melanogaster stock center for users in the United States. Thousands of mutant stocks, including those with single P element insertions that are cytologically mapped, are available. The site has links to other stock centers world-wide, including European stock centers and the supplier of other Drosophila species, the latter of which should be of interest to genomics researchers who want to do cross-species comparisons within the Drosophila genus. |
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Laurie Tompkins, Ph.D. TEL: (301) 594-0943 Photo Credit: |