This study will determine whether the metabolic and cellular mechanisms contributing to improved insulin action after aerobic or resistive exercise are different in older, obese, insulin resistant veterans. The hypothesis is that regular exercise, whether aerobic or resistive, will improve whole body insulin action, but the nature and magnitude of changes in skeletal muscle will differ between the two types of exercise.

Condition	Treatment or Intervention
Diabetes Mellitus	Procedure: Exercise

Veterans will be of comparable body composition and age, and randomly assigned to either aerobic or resistive exercise. They will be instructed in a weight maintenance diet prior to beginning the exercise program, and maintain this diet throughout the study. Metabolic testing will be performed at baseline and after 6 months of exercise training. Testing will include measurement of body composition (anthropometry, dual-energy Xray absorptiometry, computed tomograph scan), maximal oxygen consumption, and muscle strength, glucose tolerance (oral glucose tolerance test), insulin sensitivity (euglycemic-hyperinsulinemic clamp), and muscle biopsies to examine skeletal muscle metabolic characteristics (fiber type distribution, capillary density, oxidative and glycolytic enzyme activities, and levels of key proteins important in insulin signaling and glucose transport). Data will be analyzed using analysis of variance to determine differences between the two exercise groups, and multiple regression analysis to determine the primary adaptations that are associated with the improvements in whole body insulin action.

Ages Eligible for Study:  50 Years   -   80 Years,  Genders Eligible for Study:  Both

Criteria

Males between 50 years and 80 years

Overweight

Non-smoker

Sedentary (no regular exercise for one year)

Maryland
      VA Maryland Health Care System, Baltimore,  Maryland,  21201,  United States; Recruiting

Study chairs or principal investigators

Andrew P Goldberg, M.D.

Study ID Numbers:  AGCG-001-99S
Record last reviewed:  June 2001
Record first received:  July 3, 2001
ClinicalTrials.gov Identifier:  NCT00018239
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2004-10-29