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Leuprolide in Determining the Cause of Gonadotropin Deficiency
This study is currently recruiting patients.
Sponsored by: | FDA Office of Orphan Products Development University of Chicago
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Information provided by: | FDA Office of Orphan Products Development |
Purpose
RATIONALE: The body's response to one injection of leuprolide may provide more information than the standard test for gonadotropin deficiency in determining whether the cause of gonadotropin deficiency is related to the hypothalamus or the pituitary gland. PURPOSE: Randomized double-blinded clinical trial to study the effectiveness of leuprolide in determining the cause of gonadotropin deficiency.
Condition | Treatment or Intervention |
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Hypogonadism |
Drug: gonadotropin releasing hormone Drug: leuprolide |
MedlinePlus related topics: Endocrine Diseases
Study Type: Interventional
Study Design: Treatment, Randomized, Double-Blind, Efficacy Study
Official Title: Study of Gonadotropin Releasing Hormone Agonist Test Using Leuprolide Acetate in Patients with Gonadotropin Deficiency
Expected Total Enrollment: 90
Study start: December 1999
PROTOCOL OUTLINE: This is a randomized, double blind study. Patients are randomized to receive leuprolide acetate or gonadotropin releasing hormone (GnRH) first, then cross over to receive the other test. Patients receive one subcutaneous injection of leuprolide acetate or GnRH, then have blood samples drawn periodically. One month later, patients receive the other test. Another cohort of patients are randomized to receive leuprolide acetate once daily on days 0, 4, and 8, or days 0, 5, and 10. Patients are followed for up to 2 years.
Eligibility
Ages Eligible for Study: 9 Years - 18 Years, Genders Eligible for Study: Both
Criteria
PROTOCOL ENTRY CRITERIA:
--Disease Characteristics--
--Prior/Concurrent Therapy--
--Patient Characteristics--
Location and Contact Information
More Information
U.S. National Library of Medicine, Contact NLM Customer Service | ||||||||||||||
National Institutes of Health, Department of Health & Human Services | ||||||||||||||
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