The purpose of this study is to determine the effects of etanercept, and define the toxicity, when administered to patients with acute non-infectious lung injury (idiopathic pneumonia syndrome, IPS) and with subacute pulmonary dysfunction after allogeneic stem cell transplantation.

Condition	Treatment or Intervention	Phase
Respiratory Distress Syndrome, Adult Bronchiolitis Obliterans Pneumonia	Drug: etanercept	Phase I Phase II

Over the last 2 decades, allogeneic bone marrow transplantation (BMT) has emerged as an important treatment option for a number of malignant and non-malignant disorders. Unfortunately, pulmonary dysfunction remains a frequent and severe complication of allogeneic BMT. One of the main chemicals felt to cause lung damage is Tumor Necrosis Factor (TNF). Etanercept is an experimental drug that attempts to block TNF lung damage. Patients will undergo blood tests, x-rays, and a bronchoscopy with broncho-alveolar lavage prior to treatment with etanercept to check for infection. If no infection is evident after 24 hours, the etanercept will be started and administered twice weekly for 4 weeks by subcutaneous injection. There will be weekly blood tests and bronchoscopy after the last drug dose.

Ages Eligible for Study:  12 Months and above,  Genders Eligible for Study:  Both

Criteria

Inclusion criteria:

• Diagnosis of acute idiopathic pneumonia syndrome (IPS) or sub-acute lung injury
• At least 1 year of age for IPS stratum
• At least 6 years of age for sub-acute lung injury stratum and able to perform formal pulmonary function testing
• At least 14 days since prior treatment with an investigational drug for graft-versus-host disease
• Previously treated with allogeneic stem cell or bone marrow transplantation for primary disease

Exclusion criteria:

• Documented evidence of active systemic or pulmonary infection
• Cardiogenic failure as cause of pulmonary dysfunction
• Known hypersensitivity to etanercept
• Currently receiving dialysis
• Currently receiving inotropic medications except dopamine
• Pregnant or nursing

Michigan
      University of Michigan, Ann Arbor,  Michigan,  48109,  United States; Recruiting

Study chairs or principal investigators

Kenneth Cooke, M.D.,  Principal Investigator,  University of Michigan, Ann Arbor, MI   

Study ID Numbers:  FD-R-2020-01; UMCC-0078;; FD-R-002020-01
Record last reviewed:  November 2001
Record first received:  January 10, 2002
ClinicalTrials.gov Identifier:  NCT00029328
Health Authority: United States: Food and Drug Administration
ClinicalTrials.gov processed this record on 2004-11-09