NIDDK Recent Advances and Emerging Opportunities (2003)

• Mouse Models of Metabolic Diseases and Developmental Processes
• Cell Signaling Pathways and Blood Vessel Formation
• Cell Signaling and Insulin Resistance
• Tay-Sachs and Sandhoff Diseases
• Orphan Nuclear Receptors in Health and Disease
• Further Developments in Stem Cell Biology
• From Stem Cells to Specialized Cells
• Understanding the Physiology of Hematopoietic Stem Cells
• Ongoing and Newly Launched NIDDK Efforts
• Lasker Awardee: Dr. James Rothman

• Blood Sugar Control in Type 1 Diabetes: A Balancing Act
• Continued Benefits of Intensive Blood Sugar Control
• Potential Risks of Overly Tight Blood Sugar Control
• Emerging Technologies for Measuring Blood Sugar
• Injected Insulin Does Not Delay Onset of Type 1 Diabetes
• Facing Down Autoimmunity in Type 1 Diabetes Prevention and Treatment
• Cardiovascular Disease and Diabetes
• New Insights into How Calpain-10 Gene Affects Risk for Type 2 Diabetes
• Genes Directing Pancreatic Development
• Technology in Diabetes Research
• Development of New Technologies for the Treatment of Cystic Fibrosis
• Gene Therapy in Dogs with Mucopolysaccharidosis VII (MPS VII)
• Fighting Disease by Turning on Genes—Insights from Vitamin D and Guggul Tree Resin
• Developing Strategies to Overcome Immune Rejection of Transplanted Cells and Organs
• Highly Active Antiretroviral Therapy for HIV Infection—Benefits and Drawbacks
• Human Growth Hormone and Insulin Resistance
• The HAART of Insulin Resistance
• "Considering That Extra Helping?"—Gut Hormones that Influence Weight Regulation
• Identification of a Mediator of Leptin Action in Muscle
• Of Mice and Muscles: Increasing Stamina Through Gene Regulation
• Ongoing and Newly Launched NIDDK Efforts in Diabetes, Endocrinology, and Metabolic Diseases
• Patient Profile: Mollie Singer—Living With Type 1 Diabetes
• Story of Discovery: Leptin—A Potential Treatment for Lipodystrophy
• Diabetes Education at NIDDK: The National Diabetes Education Program
• Patient Profile: Monica Boone—A Patient in the Diabetes Prevention Program
• Patient Profile: Aylin Riedel—Management of Diabetes and Kidney Disease as a Daily Balancing Act
• “Vision Statement”: C. Ronald Kahn, M.D.

• Finding Ways to Understand and Treat Obesity
• Investigating Leptin’s Effects on Metabolism
• Signaling Cells to Burn Energy—An Important Part of Energy Balance
• A Genetic Locus for Severe Obesity
• Exploring Novel Compounds That May Lead to New Obesity Treatments
• NIDDK Efforts in Obesity
• T Cells and Liver Damage in Primary Biliary Cirrhosis
• New Insights from Basic and Clinical Research on Hepatitis C
• Inflammatory Bowel Disease
• Susceptibility Genes in IBD
• Improving Diagnostics for IBD Lesions
• Pointing the Way to Acute Pancreatitis Therapies
• A Molecular Profile of Mouse Stomach Cells Before and After H. Pylori Infection
• Ongoing and Newly Launched NIDDK Efforts in Digestive Diseases and Nutrition
• “Vision Statement”: Rena Wing, Ph.D.
• WIN: The Weight-Control Information Network
• Hepatitis C Consensus Conference
• Patient Profile: Rachel Hettich—Living With Crohn’s Disease
• Story of Discovery: Genetic Insights into Pancreatitis and Pancreatic Cancer
• “Vision Statement”: Jeffrey Gordon, M.D.
• Patient Profile: Chris Klug—Liver Transplant Gives Olympian More Than Just a Shot at the Gold

• Cilia and Polycystic Kidney Disease
• Understanding and Preventing Kidney Disease Progression
• Identifying Novel Genes Involved in Kidney Disease Progression
• Finding Factors That Contribute to Kidney Disease Progression— Clinical Efforts
• Preventing Progression of Kidney Disease
• New Knowledge in Dialysis
• Growing Prostate-Gland-Like Structures from Stem Cells
• Expanding Basic Research Studies of the Urinary Bladder
• Unfolding Umbrella Cells Requires New Membrane
• Hereditary Hemochromatosis: A Common Mutation That May Not Commonly Lead to Disease
• Newly Discovered Protein Stabilizes Hemoglobin Chain
• Working to Lift the Burden of Iron Overload
• Iron Overload Technologies
• Alternatives to Current Chelation Therapy
• Advancing Therapies for Sickle Cell Disease
• Gene Therapy for Sickle Cell Disease
• Stem Cells from Blood as a Therapy for Sickle Cell Disease
• Uncovering a Role for Nitric Oxide in Sickle Cell Disease Pain
• Ongoing and Newly Launched NIDDK Efforts in Kidney, Urologic, and Hematologic Diseases
• “Vision Statement”: John McConnell, M.D.
• The Bladder Research Progress Review Group: Generating a Strategic Plan for Bladder Research
• Patient Profile: Kara Fishbein Goldman—Interstitial Cystitis
• Story of Discovery: Cardiovascular Disease and Chronic Kidney Disease: Teasing out the Link
• National Kidney Disease Education Program
• "Vision Statement": Robert Schrier, M.D.
• Lasker Awardees: Dr. Willem Kolff and Dr. Belding Scribner
• NIDDK Contributions to Dialysis
• Patient Profile: Timothy Hawkins—Vesicoureteral Reflux

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