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AU:
Depree-GJ; Bledsoe-TA; Siegel-PD
TI:
Determination of zinc dialkyldithiocarbamates in
latex
condoms
SO:
J Chromatogr Sci 2004 Feb; 42(2):80-84
LT:
http://www.j-chrom-sci.com/jan-apr04.htm#
NN:
20024388
NA:
NP:
AB:
A simple high-performance liquid chromatographic (HPLC) assay is developed for measuring zinc dialkyldithiocarbamate (DTC) levels in
latex
condoms. After extraction of 14 different brands of
latex
condoms in acetonitrile, aliquots of the extracts are subjected to a preliminary screening assay by treatment with cobalt chloride and measurement of UV absorption at 320 nm, which results in the identification of 6 DTC-containing samples. Prior to analysis by HPLC, zinc dimethyldithiocarbamate (ZDMC) or zinc diethyldithiocarbamate (ZDEC) is added to the extracts in order to block transmetalation reactions with the analytes of interest. A reversed-phase C18 column, with gradient elution and UV detection at 260 nm, is used to measure the zinc DTCs. The limits of detection for ZDEC and zinc dibutyldithiocarbamate (ZDBC) are 5 and 10 micrpg/mL. Levels of ZDBC and ZDEC range from not detectable to 3.31 and 1.79 mg/condom, respectively. Total protein and
latex
allergenic protein levels are determined and range from 98 to 776 and 0.01 to 14.04 microg/unit, respectively, but are not related to the level of ZDBC or ZDEC. This methodology provides both screening and specific tools for the determination of unstable zinc DTC complexes in
latex
products.
KW:
Zinc-compounds; Chromatographic-analysis; Acetones; Nitriles; Cobalt-compounds; Chlorides
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