Dear Colleagues:

I am pleased to present this week's NCI Cancer Bulletin. Our lead story describes a new initiative to develop mathematical and predictive models of cancer on a molecular, cellular, and system level. This week's Director's Update describes the importance NCI places on monitoring patient safety in clinical trials.

Other articles of interest include:

• A research study on diabetes and the risk of liver and pancreatic cancer
• A study finding that chemotherapy, rather than tamoxifen, can increase the risk of stroke in women with breast cancer
• A special report about a film that follows six young cancer patients for 6 years
• A clinical trial that examines a drug treatment to slow the progression of tumors in children with neurofibromatosis

I hope you will find this issue of the NCI Cancer Bulletin interesting and informative.

Sincerely,

Andrew C. von Eschenbach, M.D.
Director, National Cancer Institute

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