SECTION
4 - SLEEP AND HEALTH
Sleep and Safety
Background
Demands on human wakefulness and alertness through increased
requirements for shift work , on-call and prolonged work hours,
and increased use of time for waking activities, have resulted
in more people being awake more of the time. Paralleling these
increased demands has been a growing appreciation of the risks
posed by fatigue . In this context, fatigue is defined as a
reduced capacity for cognitive performance due to time-on-task,
inadequate sleep, adverse circadian timing, or the interaction
of these factors. Fatigue can adversely affect public health
and safety, due, for example, to oil spills, truck, bus and
automobile crashes, railroad and commuter train disasters,
aviation accidents, power plant mishaps, and medical errors.
The National Highway
Traffic Safety Administration (NHTSA) estimates that 100,000–150,000
motor vehicle crashes each year and 4 percent of all fatal
crashes are caused by drowsy driving . Drowsy driving crashes
have a fatality rate and injury severity level similar to
alcohol -related crashes.
Risk factors for drowsy driving crashes include: late night/early
morning driving, people with untreated excessive sleepiness,
people who sleep 6 or fewer hours per day, young adult males
(ages 16 to 24), commercial truck drivers, and night shift
workers .
Recent reports from the National Academy of Sciences, Institute
of Medicine , concluded that as many as 100,000 patient deaths
per year may be due to medical errors. Based on surveys of
medical residents and other information, it is widely believed
that substantial numbers of these adverse events result from
fatigue due to prolonged work hours and inadequate sleep among
doctors and nurses.
These problems of sleepiness and fatigue , and the contributions
of inadequate sleep and night work, to human error and accidents
have high costs in both lives lost and economic impact. Options,
therefore, for mitigating sleepiness and fatigue need to be
explored. The Department of Transportation (DOT) is investing
significant resources to better understand and manage fatigue
in transportation systems. For example, r ecent research supported
by the Federal Motor Carrier Safety Administration suggests
that both work schedules and sleep disorders are primary contributors
to fatigue and sleepiness among truck drivers . Long and irregular
work schedules that require operators to juggle work demands
with family and social demands lead to reduced or disrupted
sleep and, therefore, to fatigue.
E xcessive fatigue and its risks are largely preventable when
the causes are identified and mitigated. For example, establishing
cost-effective techniques for identifying and treating transportation
workers (such as commercial truck drivers ) who have Sleep-Disordered
Breathing (SDB) could lessen the likelihood of fatigue-related
accidents. Preventing cumulative sleep debt by providing adequate
recovery sleep opportunities for workers could reduce the risks
of fatigue-related performance failures and catastrophic outcomes
in many industries. Moving school start times to a later hour
for adolescents could reduce the likelihood of drowsy-driving
automobile crashes and injuries in school activities in this
at-risk group. Finding ways to prevent fatigue-related medical
errors by physicians and nurses could save thousands of patient
lives each year, and improve the learning and safety of the
doctors and nurses.
Although ensuring
public and personal safety through adequate sleep is a broad
issue of interest to many Federal, State, and private entities,
the National Institutes of Health have a unique role in ensuring
that scientifically sound evidence is acquired on the basic
biomedical and health-related factors mediating sleep need,
behavioral alertness, and risk.
Progress
in the Last Five Years
Scientific
evidence increasingly demonstrates that fatigue is a significant
causal and contributing factor to adverse events including
motor vehicle and other fatigue-related accidents. However,
there is no general consensus that these data are definitive
and compelling.
Field
and simulator studies in safety-sensitive occupations (e.g.,
medical and surgical residents , truck drivers , airline
pilots ) have demonstrated that performance in real-world
tasks degrades under conditions of partial sleep loss and night
work. Such studies highlight that the biology of neurobehavioral
deficits from sleep loss and fatigue is not dependent on one's
profession, motivation, or compensation.
Experiments
have demonstrated that chronic reductions in sleep duration
by healthy adults result in cumulative deficits in basic
neurobehavioral functions, including vigilance performance,
cognitive speed and accuracy, short-term memory , and executive
functions. Such data are vital to establishing reliable, evidence-based
recommendations for sleep need.
Research
has identified some technologies that can detect fatigue
and drowsiness before they result in a serious performance
error. Some of these technologies include biobehavioral and
physiological assessments, but few have undergone rigorous
double-blind validation in controlled experiments.
Mathematical
models of the regulation of sleep have been extended to predict
waking performance capability based on sleep history, circadian
phase estimates, and additional behavioral and biological
variables. There is considerable belief that such models
can be used to precisely identify schedules that minimize
fatigue .
Recognition
that fatigue -related errors and accidents are inherent in
24/7 operations has led to fatigue management using countermeasures
that are preventive (e.g., education about the biological
basis of fatigue) and operational (e.g., naps in the workplace).
These fatigue management interventions have only recently
been developed, however, and have not yet been widely studied
to determine the extent to which they will be effective.
Work-related
sleep loss and fatigue in medical professionals, particularly
during training , has until recently received little attention.
There have been relatively few controlled studies that have
examined the impact of sleep loss and fatigue in the medical
setting, and many published studies are methodologically
flawed. The consequences related to sleep loss and shift
work among physicians and nurses include effects on performance
of professional duties, learning and memory , personal health
and family consequences, and safety and liability. While the
issue of work hours for physicians and nurses is currently
being debated nationally, there remains a need for research
to elucidate the effects of education and training of physicians
and nurses in sleep and fatigue management.
Research
Recommendations
Identify
the effects of varying amounts of time for sleep, rest,
and recovery (e.g., days off) on biological and behavioral
resilience to fatigue- inducing
work schedules. One of the most contentious but least well-understood
features of fatigue and its consequences for safety concerns
the role of recovery days off work. There are very limited
data on the chronic (over weeks and months) effects of inadequate
recovery opportunities outside the circadian cycle.
There is a need to establish time-constants for fatigue buildup
as a function of different recovery opportunities. Another
need is to identify ways to scientifically design
and evaluate work schedules that prevent the accumulation
of excessive fatigue by allowing restorative sleep at reasonable
intervals.
Establish
the validity and reliability of innovative biobehavioral
technologies and monitoring techniques that can detect
drowsiness, fatigue and
sleep propensity in medical and other workplaces. As devices
predicated on detecting changes in the biology of wakefulness,
these technologies have great potential. To be used effectively
as either diagnostic devices or safety devices, however,
they should meet rigorous standards for determining whether
what is being measured is related to the neurobehavioral
deficits induced by sleepiness and fatigue.
Establish
the biological benefits for brain function, performance,
and safety of nap sleep interventions (number of naps , their
durations and circadian timing) as a sleep loss countermeasure
and fatigue management strategy. Increasingly, 24/7 industries
permit opportunities for naps in the workplace (e.g., sleeper
berths on trucks, bunks on airplanes, sleeping areas on trains,
on-call rooms for residents). There is a need for laboratory,
simulator and field experiments on nap sleep physiology and
waking neurobehavioral functions to establish the effectiveness
of naps used repeatedly as countermeasures. There are many
experiments on naps in response to acute sleep loss, but
few that determine whether chronic use of naps or split sleep
opportunities can effectively maintain waking neurobehavioral
functions. If optimal napping strategies can be found to manage
sleepiness and its neurobehavioral effects, this can form a
basis for evaluating evidenced-based model fatigue management
to determine the extent to which fatigue-related neurobehavioral
deficits and risks can be reduced.
Assess the impact of sleep loss and fatigue in
the context of medical training , including quality of patient
care and patient safety/medical errors, learning and memory
in medical education, and the health and well-being of resident
physicians (motor vehicle crashes , mental health, etc.). Evaluate
the effectiveness of fatigue management educational programs
in improving the health and well being of medical trainees,
including evaluation of the effectiveness of controlled countermeasures
(napping, caffeine , etc.) and evaluation of the impact of "systemic" interventions
(work hour restrictions, "night float" etc.) on sleep
loss, performance, and medical errors.
Develop
cost-effective methods to screen populations working in safety-sensitive
occupations to identify those who are most likely to have
sleep disorders that produce excessive sleepiness and performance-impairing
risks. A major impediment to removing the risks posed by
sleepiness due to unrecognized sleep disorders in the workplace
is the lack of valid, simple, cost-effective tools for identifying
who is most likely to benefit from a full evaluation. Such
tools are needed, however, to enable physicians to certify
that people in specific safety-sensitive occupations are
fit to perform their jobs safely.
Develop
novel techniques to facilitate worker acclimation to therapeutic
interventions and effective use of therapies for sleep disorders
(e.g., CPAP adherence). It is not sufficient to diagnose
and to treat workers without a treatment compliance program
in place.
Perform
studies on the effects of chronic pharmacological enhancement
of wakefulness in healthy persons on biology, behavior, and
safety. This should extend from unregulated stimulants (e.g.,
caffeine ), to regulated stimulants (e.g., amphetamines),
and novel wake-promoting substances. These studies should include
identification of long-term effectiveness, side effects, and
complications of use and abuse.
Assess
the extent to which educational programs on the biological
basis of fatigue , and mitigation of the performance deficits
produced by it, are (1) effective in facilitating improved
sleep, alertness, and the use of fatigue countermeasures,
and (2) result in reduced risks of adverse events due to sleep
loss and circadian biology.
Determine
the extent to which mathematical models of waking performance
capability (relative to dynamic interactions of sleep and
circadian biology) can be used to precisely identify and
develop work-rest schedules that minimize fatigue . Although
efforts have been underway to identify the strengths and weaknesses
of such computational models, more research is needed to ensure
they accurately reflect the underlying biology of circadian
rhythms and homeostatic sleep need as they pertain to work-rest
schedules.
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