From Salt Lake City, Utah (approximately 275 miles):
I-15 to Idaho Falls. Highway 26 to Swan Valley. Highway 31 over Pine Creek Pass to Victor. Highway 22 over Teton Pass, through Wilson to Jackson. If you would like to avoid the 10% grade of Teton Pass, take Highway 26 from Idaho Falls to Swan Valley. Continue on Highway 26 to Alpine Junction. Highway 26/89 to Hoback Junction. Highway 191 to Jackson. or I-80 to Evanston. Highway 89/16 to Woodruff, Randolph, and Sage Creek Junction. Highway 30/89 to Cokeville and then Border. Continue on Highway 89 to Afton, and then to Alpine Junction. Highway 26/89 to Hoback Junction. Highway 191 to Jackson.
From Denver, Colorado (approximately 550 miles):
I-25N to Cheyenne. I-80W through Laramie to Rock Springs. Highway 191 North through Pinedale. Highway 191/189 to Hoback Junction. Highway 191 to Jackson. or I-25N to Fort Collins, Highway 287 North to Laramie. I-80W to Rawlins. Highway 287 to Muddy Gap Junction. Continue on Highway 287 to Jeffrey City, Lander, Fort Washakie, Crowheart, and Dubois. Highway 287/26 over Togwotee Pass to Moran. Highway 26/89/191 to Jackson.