HomoloGene is a system for automated detection of homologs among the annotated genes of several completely sequenced eukaryotic geneomes.

HomoloGene Release Statistics Initial numbers of genes from complete genomes, numbers of genes placed in a homology group, and the numbers of groups for each species HomoloGene Build 37.2 Species Number of Genes HomoloGene   input grouped   Groups H.sapiens 23,144 17,654   16,998 M.musculus 24,954 19,545   18,100 R.norvegicus 20,913 17,440   16,437 D.melanogaster 12,918 7,445   7,356 A.gambiae 12,012 7,580   7,251 C.elegans 19,109 3,171   2,768 S.pombe 4,947 2,863   2,824 S.cerevisiae 5,863 4,414   4,289 E.gossypii 4,726 3,924   3,917 N.crassa 10,079 5,446   5,439 M.grisea 11,109 5,743   5,449 A.thaliana 26,281 5,670   5,411 P.falciparum 5,222 1,168   1,153 Last updated on: 10/25/2004 We have recently adopted a new build procedure which makes use of amino acid sequence searching (blastp) to find more distant relationships, but still refers to the DNA sequence for computation of some of the statistics. The matching strategy is guided by the taxonomic tree, such that more closely related organisms are compared first. Moreover, HomoloGene entries now include paralogs in addition to orthologs. Sources of Additional Information HomoloGene entries have been augumented with homology and phenotype information drawn from the following sources. Online Mendelian Inheritance in Man (OMIM) Mouse Genome Informatics (MGI) Zebrafish Information Network (ZFIN) Saccharomyces Genome Database (SGD) Clusters of Orthologous Groups (COG) FlyBase

Related Resources Entrez Genome A collection of complete genome sequences that includes more than 1000 viruses and over hundred microbes   Archaea   Bacteria   Eukaryota   Viruses Tax Plot Three-way view of genome similarities Compare A. gambiae str. PEST A. thaliana C. elegans D. melanogaster Homo sapiens Mus musculus P. falciparum (malaria) P. falciparum 3D7 Rattus norvegicus S. cerevisiae S. pombe to A. gambiae str. PEST A. thaliana C. elegans D. melanogaster Homo sapiens Mus musculus P. falciparum (malaria) P. falciparum 3D7 Rattus norvegicus S. cerevisiae S. pombe and A. gambiae str. PEST A. thaliana C. elegans D. melanogaster Homo sapiens Mus musculus P. falciparum (malaria) P. falciparum 3D7 Rattus norvegicus S. cerevisiae S. pombe   COGs Phylogenetic classification of proteins encoded in complete genomes.