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Behavioral Neuroscience Research Branch Mission Statement The Integrative Neuroscience Section conducts basic science studies aimed at: (i) elucidating the circuits within the brain upon which psychostimulants and opiates act to control behavior and (ii) identifying neurodapatations that occur within these circuits upon repeated drug use that underlie compulsive drug use. These studies are driven by the hypothesis that dysregulation of specific neurotransmitter systems occurs following the repeated administration of drugs of abuse and that the identification of the mechanisms, both at the cellular and systems levels, by which drugs affect these systems can lead to effective strategies for the treatment of drug addiction. Program Areas Intercellular and Intracellular Mechanisms of Dopamine Transporter Regulation; Modulation of Neurotransmitter Release and Uptake By Neuropeptides and Drugs of Abuse; Neurochemical Mechanisms Underlying the Interactions of Endogenous Opioid Peptide Systems With Psychostimulants Name: Toni S. Shippenberg, Ph.D. Title: Chief, Integrative Neuroscience Section, IRP, NIDA, NIH Telephone Number: (410) 550-1451 Synopsis of Research Basic science studies are conducted at the cellular, systems and behavioral levels to identify alterations in neurotransmission that occur in the CNS following the repeated administration of drugs of abuse in order to promote development of pharmacological strategies for the treatment of opiate and psychostimulant addiction.
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